Transcription factor RFX4 is a protein that in humans is encoded by the RFX4gene.[1][2][3]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.[3]
↑Morotomi-Yano K, Yano K, Saito H, Sun Z, Iwama A, Miki Y (Jan 2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J Biol Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID11682486.
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Gajiwala KS, Chen H, Cornille F, et al. (2000). "Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding". Nature. 403 (6772): 916–21. doi:10.1038/35002634. PMID10706293.
Blackshear PJ, Graves JP, Stumpo DJ, et al. (2003). "Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4". Development. 130 (19): 4539–52. doi:10.1242/dev.00661. PMID12925582.
Araki R, Takahashi H, Fukumura R, et al. (2004). "Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus". J. Biol. Chem. 279 (11): 10237–42. doi:10.1074/jbc.M312761200. PMID14701801.
Glaser B, Kirov G, Bray NJ, et al. (2005). "Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4". Mol. Psychiatry. 10 (10): 920–7. doi:10.1038/sj.mp.4001689. PMID15940297.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID16189514.
Matsushita H, Uenaka A, Ono T, et al. (2006). "Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients". Cancer Sci. 96 (11): 801–9. doi:10.1111/j.1349-7006.2005.00112.x. PMID16271074.
