BHLHB2

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.

Function

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.

Further reading

• Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, Tsutsumi S, Kawamoto T, Iwamoto Y, Kato Y (Mar 2001). "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2". Journal of Biochemistry. 129 (3): 391–6. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878.
• Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (May 2001). "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". The Journal of Biological Chemistry. 276 (18): 15306–15. doi:10.1074/jbc.M010516200. PMID 11278694.
• Sun H, Lu B, Li RQ, Flavell RA, Taneja R (Nov 2001). "Defective T cell activation and autoimmune disorder in Stra13-deficient mice". Nature Immunology. 2 (11): 1040–7. doi:10.1038/ni721. PMID 11668339.
• Yoon DY, Buchler P, Saarikoski ST, Hines OJ, Reber HA, Hankinson O (Nov 2001). "Identification of genes differentially induced by hypoxia in pancreatic cancer cells". Biochemical and Biophysical Research Communications. 288 (4): 882–6. doi:10.1006/bbrc.2001.5867. PMID 11688991.
• Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, Wan Y, Yan B (Oct 2002). "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation". The Biochemical Journal. 367 (Pt 2): 413–22. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049.
• St-Pierre B, Flock G, Zacksenhaus E, Egan SE (Nov 2002). "Stra13 homodimers repress transcription through class B E-box elements". The Journal of Biological Chemistry. 277 (48): 46544–51. doi:10.1074/jbc.M111652200. PMID 12297495.
• Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y (Dec 2002). "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes". The Journal of Biological Chemistry. 277 (49): 47014–21. doi:10.1074/jbc.M204938200. PMID 12354771.
• Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, Fujimoto K, Noshiro M, Kato Y (Dec 2002). "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages". The Journal of Biological Chemistry. 277 (51): 50112–20. doi:10.1074/jbc.M206771200. PMID 12384505.
• Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, Kato Y, Honma K (Oct 2002). "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature. 419 (6909): 841–4. doi:10.1038/nature01123. PMID 12397359.
• Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, Yan B (May 2003). "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter". The Journal of Biological Chemistry. 278 (19): 16899–907. doi:10.1074/jbc.M300596200. PMID 12624110.
• Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Wykoff CC, Gatter KC, Harris AL (Jun 2003). "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer". The Journal of Pathology. 200 (2): 222–8. doi:10.1002/path.1330. PMID 12754744.
• Ivanova AV, Ivanov SV, Zhang X, Ivanov VN, Timofeeva OA, Lerman MI (Jul 2004). "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". Journal of Molecular Biology. 340 (4): 641–53. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.
• Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda KK, Honma S, Honma K, Kato Y (Nov 2004). "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1". European Journal of Biochemistry / FEBS. 271 (22): 4409–19. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.
• Ivanova AV, Ivanov SV, Lerman ML (Feb 2005). "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins". Cellular and Molecular Life Sciences. 62 (4): 471–84. doi:10.1007/s00018-004-4423-2. PMID 15719173.
• Ivanova A, Liao SY, Lerman MI, Ivanov S, Stanbridge EJ (Jul 2005). "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker". Journal of Medical Genetics. 42 (7): 565–76. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

External links

• BHLHB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook BHLHE40
• Human BHLHE40 genome location and BHLHE40 gene details page in the UCSC Genome Browser.
• Human DEC1 genome location and DEC1 gene details page in the UCSC Genome Browser.
• Human STRA13 genome location and STRA13 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.