IRF1

Interferon regulatory factor 1
PDB rendering based on 1if1.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1if1​
Identifiers
Symbols	IRF1 ; IRF-1; MAR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1658
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Interferon regulatory factor 1, also known as IRF1, is a human gene.

IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.

See also

• IRF2
• Interferon regulatory factors

Further reading

• Harada H, Taniguchi T, Tanaka N (1999). "The role of interferon regulatory factors in the interferon system and cell growth control". Biochimie. 80 (8–9): 641–50. PMID 9865486.CS1 maint: Multiple names: authors list (link)
• Pitha PM, Au WC, Lowther W; et al. (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth". Biochimie. 80 (8–9): 651–8. PMID 9865487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu-Lee L (2002). "Stimulation of interferon regulatory factor-1 by prolactin". Lupus. 10 (10): 691–9. PMID 11721695.
• Pine R (2002). "IRF and tuberculosis". J. Interferon Cytokine Res. 22 (1): 15–25. doi:10.1089/107999002753452629. PMID 11846972.
• Romeo G, Fiorucci G, Chiantore MV; et al. (2002). "IRF-1 as a negative regulator of cell proliferation". J. Interferon Cytokine Res. 22 (1): 39–47. doi:10.1089/107999002753452647. PMID 11846974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cha Y, Sims SH, Romine MF; et al. (1992). "Human interferon regulatory factor 1: intron-exon organization". DNA Cell Biol. 11 (8): 605–11. PMID 1382447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Itoh S, Harada H, Nakamura Y; et al. (1991). "Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31". Genomics. 10 (4): 1097–9. PMID 1680796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada H, Fujita T, Miyamoto M; et al. (1989). "Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes". Cell. 58 (4): 729–39. PMID 2475256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama M, Fujita T, Taniguchi T (1989). "Sequence of a cDNA coding for human IRF-1". Nucleic Acids Res. 17 (8): 3292. PMID 2726461.CS1 maint: Multiple names: authors list (link)
• Miyamoto M, Fujita T, Kimura Y; et al. (1988). "Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements". Cell. 54 (6): 903–13. PMID 3409321.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harada H, Takahashi E, Itoh S; et al. (1994). "Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system". Mol. Cell. Biol. 14 (2): 1500–9. PMID 7507207.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharf R, Azriel A, Lejbkowicz F; et al. (1995). "Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors". J. Biol. Chem. 270 (22): 13063–9. PMID 7768900.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willman CL, Sever CE, Pallavicini MG; et al. (1993). "Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia". Science. 259 (5097): 968–71. PMID 8438156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drew PD, Franzoso G, Becker KG; et al. (1997). "NF kappa B and interferon regulatory factor 1 physically interact and synergistically induce major histocompatibility class I gene expression". J. Interferon Cytokine Res. 15 (12): 1037–45. PMID 8746784.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ronco LV, Karpova AY, Vidal M, Howley PM (1998). "Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity". Genes Dev. 12 (13): 2061–72. PMID 9649509.CS1 maint: Multiple names: authors list (link)
• Nozawa H, Oda E, Ueda S; et al. (1998). "Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer". Int. J. Cancer. 77 (4): 522–7. PMID 9679752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schaper F, Kirchhoff S, Posern G; et al. (1998). "Functional domains of interferon regulatory factor I (IRF-1)". Biochem. J. 335 ( Pt 1): 147–57. PMID 9742224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masumi A, Wang IM, Lefebvre B; et al. (1999). "The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness". Mol. Cell. Biol. 19 (3): 1810–20. PMID 10022868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• IRF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.