SREBF1

Sterol regulatory element binding transcription factor 1
File:PBB Protein SREBF1 image.jpg PDB rendering based on 1am9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1am9​
Identifiers
Symbols	SREBF1 ; SREBP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3079
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SREBF1 202308 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Sterol regulatory element binding transcription factor 1, also known as SREBF1, is a human gene.

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

See also

• Sterol regulatory element binding protein

Further reading

• Osborne TF (2001). "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin". Genes Dev. 15 (15): 1873–8. doi:10.1101/gad.916601. PMID 11485982.
• Kotzka J, Müller-Wieland D (2006). "Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance?". Expert Opin. Ther. Targets. 8 (2): 141–9. doi:10.1517/14728222.8.2.141. PMID 15102555.
• Szolkiewicz M, Chmielewski M, Nogalska A; et al. (2007). "The potential role of sterol regulatory element binding protein transcription factors in renal injury". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 17 (1): 62–5. doi:10.1053/j.jrn.2006.10.009. PMID 17198935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ferré P, Foufelle F (2007). "SREBP-1c transcription factor and lipid homeostasis: clinical perspective". Horm. Res. 68 (2): 72–82. doi:10.1159/000100426. PMID 17344645.
• Hua X, Wu J, Goldstein JL; et al. (1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13". Genomics. 25 (3): 667–73. PMID 7759101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hua X, Yokoyama C, Wu J; et al. (1994). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11603–7. PMID 7903453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato R, Yang J, Wang X; et al. (1994). "Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)". J. Biol. Chem. 269 (25): 17267–73. PMID 8006035.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang X, Sato R, Brown MS; et al. (1994). "SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis". Cell. 77 (1): 53–62. PMID 8156598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang X, Briggs MR, Hua X; et al. (1993). "Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization". J. Biol. Chem. 268 (19): 14497–504. PMID 8314806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokoyama C, Wang X, Briggs MR; et al. (1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell. 75 (1): 187–97. PMID 8402897.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hua X, Sakai J, Brown MS, Goldstein JL (1996). "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane". J. Biol. Chem. 271 (17): 10379–84. PMID 8626610.CS1 maint: Multiple names: authors list (link)
• Shimomura I, Shimano H, Horton JD; et al. (1997). "Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells". J. Clin. Invest. 99 (5): 838–45. PMID 9062340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miserez AR, Cao G, Probst LC, Hobbs HH (1997). "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)". Genomics. 40 (1): 31–40. doi:10.1006/geno.1996.4525. PMID 9070916.CS1 maint: Multiple names: authors list (link)
• Párraga A, Bellsolell L, Ferré-D'Amaré AR, Burley SK (1998). "Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution". Structure. 6 (5): 661–72. PMID 9634703.CS1 maint: Multiple names: authors list (link)
• Ericsson J, Edwards PA (1998). "CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription". J. Biol. Chem. 273 (28): 17865–70. PMID 9651391.
• Bennett MK, Ngo TT, Athanikar JN; et al. (1999). "Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein". J. Biol. Chem. 274 (19): 13025–32. PMID 10224053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moldes M, Boizard M, Liepvre XL; et al. (2000). "Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes". Biochem. J. 344 Pt 3: 873–80. PMID 10585876.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• DeBose-Boyd RA, Brown MS, Li WP; et al. (2000). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi". Cell. 99 (7): 703–12. PMID 10619424.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roth G, Kotzka J, Kremer L; et al. (2000). "MAP kinases Erk1/2 phosphorylate sterol regulatory element-binding protein (SREBP)-1a at serine 117 in vitro". J. Biol. Chem. 275 (43): 33302–7. doi:10.1074/jbc.M005425200. PMID 10915800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimomura I, Matsuda M, Hammer RE; et al. (2000). "Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice". Mol. Cell. 6 (1): 77–86. PMID 10949029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• SREBF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.