Diphenadione: Difference between revisions
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{{ | ==Overview== | ||
'''Diphenadione''' is a [[vitamin K]] [[antagonist]] which has [[anticoagulant]] effects and is used as a [[rodenticide]] against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an [[anti-coagulant]] with longer activity than [[warfarin]] and other synthetic indandione [[anticoagulants]].<ref>{{cite web|url=http://pmep.cce.cornell.edu/profiles/extoxnet/dienochlor-glyphosate/diphacinone-ext.html |title=Diphacinone |publisher=Pmep.cce.cornell.edu |date= |accessdate=2011-12-07}}</ref> | |||
== | ==Safety and Toxicity== | ||
Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting and irregular heartbeats.<ref>Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.</ref> An online pesticide database gives more information about the safety of diphenadione.<ref>{{cite web|url=http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC35081 |title=Diphacinone - toxicity, ecological toxicity and regulatory information |publisher=Pesticideinfo.org |date= |accessdate=2011-12-07}}</ref> The [[U.S. Environmental Protection Agency]] has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.<ref>{{cite book|title=Recognition and management of pesticide poisonings (5th edition)|author=Routt Reigart and James Roberts|url=http://www.epa.gov/oppfead1/safety/healthcare/handbook/handbook.htm|year=1999|publisher=[[USEPA]]}}</ref> For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."<ref>Reigart, page 169.</ref> | |||
==References== | ==References== | ||
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Latest revision as of 00:39, 26 July 2014
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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| Formula | C23H16O3 |
| Molar mass | 340.371 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.[1]
Safety and Toxicity
Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting and irregular heartbeats.[2] An online pesticide database gives more information about the safety of diphenadione.[3] The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.[4] For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."[5]
References
- ↑ "Diphacinone". Pmep.cce.cornell.edu. Retrieved 2011-12-07.
- ↑ Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.
- ↑ "Diphacinone - toxicity, ecological toxicity and regulatory information". Pesticideinfo.org. Retrieved 2011-12-07.
- ↑ Routt Reigart and James Roberts (1999). Recognition and management of pesticide poisonings (5th edition). USEPA.
- ↑ Reigart, page 169.
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