Diphenadione: Difference between revisions
Matt Pijoan (talk | contribs) m (Protected "Diphenadione": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))) |
No edit summary |
||
| (2 intermediate revisions by 2 users not shown) | |||
| Line 24: | Line 24: | ||
| routes_of_administration = | | routes_of_administration = | ||
}} | }} | ||
__NOTOC__ | |||
{{SI}} | {{SI}} | ||
{{CMG}} | {{CMG}} | ||
{{ | ==Overview== | ||
'''Diphenadione''' is a [[vitamin K]] [[antagonist]] which has [[anticoagulant]] effects and is used as a [[rodenticide]] against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an [[anti-coagulant]] with longer activity than [[warfarin]] and other synthetic indandione [[anticoagulants]].<ref>{{cite web|url=http://pmep.cce.cornell.edu/profiles/extoxnet/dienochlor-glyphosate/diphacinone-ext.html |title=Diphacinone |publisher=Pmep.cce.cornell.edu |date= |accessdate=2011-12-07}}</ref> | |||
== | ==Safety and Toxicity== | ||
Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting and irregular heartbeats.<ref>Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.</ref> An online pesticide database gives more information about the safety of diphenadione.<ref>{{cite web|url=http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC35081 |title=Diphacinone - toxicity, ecological toxicity and regulatory information |publisher=Pesticideinfo.org |date= |accessdate=2011-12-07}}</ref> The [[U.S. Environmental Protection Agency]] has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.<ref>{{cite book|title=Recognition and management of pesticide poisonings (5th edition)|author=Routt Reigart and James Roberts|url=http://www.epa.gov/oppfead1/safety/healthcare/handbook/handbook.htm|year=1999|publisher=[[USEPA]]}}</ref> For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."<ref>Reigart, page 169.</ref> | |||
==References== | ==References== | ||
{{ | {{reflist|2}} | ||
{{Antithrombotics}} | {{Antithrombotics}} | ||
[[Category:Drugs]] | [[Category:Drug]] | ||
[[Category:Cardiovascular Drugs]] | |||
[[Category:Anticoagulants]] | |||
Latest revision as of 00:39, 26 July 2014
| Clinical data | |
|---|---|
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C23H16O3 |
| Molar mass | 340.371 g/mol |
|
WikiDoc Resources for Diphenadione |
|
Articles |
|---|
|
Most recent articles on Diphenadione Most cited articles on Diphenadione |
|
Media |
|
Powerpoint slides on Diphenadione |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Diphenadione at Clinical Trials.gov Clinical Trials on Diphenadione at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Diphenadione
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Diphenadione Discussion groups on Diphenadione Patient Handouts on Diphenadione Directions to Hospitals Treating Diphenadione Risk calculators and risk factors for Diphenadione
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Diphenadione |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Diphenadione is a vitamin K antagonist which has anticoagulant effects and is used as a rodenticide against rats, mice, voles, ground squirrels and other rodents. This chemical compound is an anti-coagulant with longer activity than warfarin and other synthetic indandione anticoagulants.[1]
Safety and Toxicity
Diphenadione is highly toxic for human skin by all means of contact. Consumption of the drug may cause major blood clotting and irregular heartbeats.[2] An online pesticide database gives more information about the safety of diphenadione.[3] The U.S. Environmental Protection Agency has issued a safety handbook which explains how incidents of poisoning with similar rodenticides are usually treated.[4] For treatment purposes Vitamin K antagonists like diphenadione are placed under the heading of coumarins and indandiones. The handbook notes that "...as agents specifically designed to kill mammals, often their toxicity is very similar for the target rodents and for humans."[5]
References
- ↑ "Diphacinone". Pmep.cce.cornell.edu. Retrieved 2011-12-07.
- ↑ Bell Laboratories, Inc. July, 1990. Diphacinone Technical: MSDS. Bell Labs, Madison, WI.
- ↑ "Diphacinone - toxicity, ecological toxicity and regulatory information". Pesticideinfo.org. Retrieved 2011-12-07.
- ↑ Routt Reigart and James Roberts (1999). Recognition and management of pesticide poisonings (5th edition). USEPA.
- ↑ Reigart, page 169.
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Infobox drug articles without a structure image
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Drug
- Cardiovascular Drugs
- Anticoagulants