Lactic acidosis causes: Difference between revisions

Jump to navigation Jump to search
← Older edit
VisualWikitext
No edit summary
Deepika Beereddy (talk | contribs)
nocaptcha
6,051 edits
 
(22 intermediate revisions by 6 users not shown)
Line 3: Line 3:
{{CMG}}
{{CMG}}
==Overview==
==Overview==
*[[AIDS]]
Lactic acidosis is one of the most common causes of high [[anion gap]] [[metabolic acidosis]] and is usually associated with a serum [[lactate]] levels above 4 mmol/L.  Reduced oxygen tension shunts [[glycolysis]] towards [[pyruvate]] production, which in turn leads to lactate accumulation since pyruvate can no longer undergo [[aerobic metabolism]].
*[[Cancer]]
* Drugs, toxins
* End-stage [[renal failure]]
* Fetal compromise during childbirth
* [[Glycogen storage disease]]
* [[Heart failure]]
* Heavy exercise
* [[Hypothermia]]
* [[Hypoventilation]] with [[hypercapnia]]
* [[Hypovolemia]]
* Infusions
* [[Leukemia]]
* [[Hepatic failure|Liver failure]]
* [[Myocardial Infarction]]
* Postoperative state
* [[Seizures]]
* [[Sepsis]]
* Severe [[anemia]]
* Severe [[thiamine deficiency]]
* [[Tumors]]
* Uncontrolled [[diabetes mellitus]]


===Common Causes===
==Causes==
*[[Shock ]]
===Life Threatening Causes===
Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated.
*[[Cardiac arrest]]
*[[Cardiac arrest]]
*[[Mesenteric ischemia]]
*[[Mesenteric ischemia]]
*[[Sepsis]]
*[[Sepsis]]
*[[Shock]]
===Common Causes===
*[[Alcoholism]]
*[[Carbon monoxide poisoning]]
*[[Cyanide poisoning]]
*[[Exercise]]
*[[Grand mal seizure]]
*[[Hypoglycemia]]
*[[Hypoxemia]]
*[[Malignancy]]
*[[Metformin]]
*[[Pheochromocytoma]]
*[[Pulmonary edema]]
*[[Salicylate intoxication]]
*[[Stavudine]]
*[[Zidovudine]]


===Causes by Organ System===
===Causes by Organ System===
{|style="width:82%; height:100px" border="1"
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |ST Elevation [[Myocardial Infarction]] Complications , [[Shock]] , [[Heart diseases]] , [[Cardiomyopathy ]] , [[Cardiac arrest ]] , [[Beriberi Heart Disease]] , Acute [[pulmonary edema ]]
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Cardiac arrest]],  [[cardiac catheterization]],  [[cardiomyopathy]],  [[heart failure]],  [[hemorrhage]], [[hypoperfusion]], [[hypovolemia]], [[multiple organ dysfunction syndrome]], [[myocardial infarction]], [[shock]], [[ST elevation myocardial infarction complications]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Chemical/Poisoning'''
| '''Chemical/Poisoning'''
|bgcolor="Beige"|[[Isopropyl alcohol]] , [[Ethanol]] , [[Cyanide]] intoxication , Crotalidae snake [[poisoning ]], Copperhead snake [[poisoning ]], [[Contrast medium]] , Complications During and Following [[Cardiac Catheterization]], [[Carbon monoxide poisoning ]] ,  [[Alcoholism ]]
|bgcolor="Beige"| [[Alcoholism]], [[carbon monoxide poisoning]],  [[contrast medium]], [[cyanide poisoning]], [[ethanol]], [[intravenous pyelogram]],  [[isopropyl alcohol]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 51: Line 47:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"|[[Zalcitabine]] , [[Tenofovir ]] , [[Telbivudine ]] , [[Succinyl-CoA]] synthetase deficiency , [[Stavudine]] , [[Phenformin]] , [[Paracetamol]] , [[Metformin]] , [[Linezolid]] , [[Lamivudine ]] , [[Glyburide and Metformin ]] , [[Entecavir ]] , [[Emtricitabine]] , [[Didanosine]] , [[Buformin]] , [[Biguanide]] , [[Atenolol]] , [[Ariboflavinosis]] , [[Adefovir ]] , [[Abacavir]] , [[Abacavir]]
|bgcolor="Beige"| [[Abacavir]], [[adefovir]], [[atenolol]], [[biguanide]], [[buformin]], [[didanosine]], [[emtricitabine]], [[entecavir]], [[Glyburide and Metformin]], [[lamivudine]], [[Linagliptin and Metformin hydrochloride]],  [[linezolid]],  [[metformin]],  [[paracetamol]],  [[phenformin]], [[Repaglinide and Metformin hydrochloride]],   [[Reye's syndrome]], [[salicylate intoxication]], [[Saxagliptin hydrochloride and Metformin hydrochloride]], [[stavudine]], [[strychnine]], [[telbivudine]], [[tenofovir]], [[zalcitabine]], [[Zidovudine]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"|[[Pheochromocytoma ]] , [[Latent autoimmune diabetes]] , [[Hypoglycemia]] , [[Diabetic nephropathy]] , [[Diabetes mellitus]]
|bgcolor="Beige"| [[Diabetic nephropathy]], [[hypoglycemia]], [[latent autoimmune diabetes]], [[metabolic syndrome]]
|-
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"|[[Smoke inhalation ]]
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"|[[Short bowel syndrome]] , [[Mesenteric ischemia]] , [[Liver disease]] , [[Intestinal ischaemia]] , [[Hepatic failure]] , [[Bacterial]] overgrowth of [[small intestine]] , [[Acute liver failure]]  
|bgcolor="Beige"| [[Acute liver failure]], [[intestinal ischemia]], [[liver failure]], [[mesenteric ischemia]], [[short bowel syndrome]], [[small bowel bacterial overgrowth]]
 
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"|Type I [[Glycogen Storage Disease ]], Type 1 [[glycogen storage disease ]], SCHAD deficiency , [[Pyruvate dehydrogenase]] phosphatase deficiency , [[Pyruvate dehydrogenase]] deficiency, [[Pyruvate decarboxylase]] deficiency, [[Pyruvate carboxylase]] deficiency, Pyridoxine-5'-phosphate oxidase deficiency, Myopathy with deficiency of [[succinate dehydrogenase]] and aconitase, [[Mitochondrial]] genome inherited conditions, [[Mitochondrial]] encephalomyopathy -- aminoacidopathy , [[Mitochondrial ]]DNA depletion syndrome , [[Mitochondrial]] aspartyl-tRNA synthetase deficiency , Medium and long chan 3-hydroxyacyl-coenzyme A dehydrogenase deficiency , [[Malonyl-CoA]] decarboxylase deficiency, [[Malonyl-CoA]] decarboxylase deficiency , [[Malignant hyperpyrexia]], Hydroxyacyl-coa dehydrogenase type 2 deficiency , Holocarboxylase synthase deficiency , GRACILE syndrome ,[[Glycogenosis]] type 1b, [[Glycogenosis]] type 1a, [[Glycogen Storage Disease]] Type I , [[Glycogen storage disease]] type 1D , [[Glycogen storage disease]] type 1C , Fructose-1,6-bisphosphatase deficiency, , Fructose-1,6-diphosphatase deficiency, Fructose-1-phosphate aldolase deficiency, [[Fructose]] intolerance, [[Dihydrolipoamide dehydrogenase]] deficiency, Decreased activity of [[pyruvate dehydrogenase  ]], Decreased activity [[pyruvate carboxylase ]], 3-methylglutaconic aciduria, type 4  , 3-Hydroxyisobutyric aciduria, 3-Hydroxyacyl-CoA Dehydrogenase II Deficiency , 17- beta-hydroxysteroid dehydrogenase X deficiency
|bgcolor="Beige"| [[Fructose intolerance]], [[fructose-1-phosphate aldolase deficiency]], [[fructose-1,6-diphosphatase deficiency]], [[glycogen storage disease]], [[holocarboxylase synthase deficiency]], [[MELAS]], [[MERRF]], [[mitochondrial myopathy]], [[pyruvate carboxylase deficiency]], [[pyruvate dehydrogenase deficiency]],  [[von Gierke disease]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"|[[Burkitt's lymphoma]]
|bgcolor="Beige"| [[Anemia]], [[Burkitt's lymphoma]],  [[leukemia]],  [[non Hodgkin's lymphoma]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Cardiac catheterization]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"|[[Sepsis]] , [[Acquired immune deficiency syndrome  ]]  
|bgcolor="Beige"| [[Acquired immune deficiency syndrome]], [[sepsis]], [[small bowel bacterial overgrowth]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 91: Line 87:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"|Subacute necrotising encephalomyelopathy , [[Grand mal seizure ]] , [[Ethylmalonic encephalopathy]]
|bgcolor="Beige"| [[Ethylmalonic encephalopathy]], [[grand mal seizure]], [[seizures]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"|[[Von Gierke Disease ]] , [[Mitochondrial]] toxicity , [[Mitochondrial]] neurogastrointestinal encephalopathy syndrome , [[Mitochondrial myopathy]] , Impaired [[pyruvate]] utilization , [[Coenzyme Q10]] deficiency  
|bgcolor="Beige"| [[Ariboflavinosis]], [[beriberi heart disease]], [[fructose intolerance]], [[fructose-1-phosphate aldolase deficiency]], [[fructose-1,6-diphosphatase deficiency]], [[pyruvate carboxylase deficiency]], [[pyruvate dehydrogenase deficiency]],  [[thiamine deficiency]]
|
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"|[[Fetal distress]]
|bgcolor="Beige"| [[Fetal distress]],  [[oligohydramnios]],
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"|[[Non Hodgkin's lymphoma]] , [[Malignancy ]]
|bgcolor="Beige"| [[Burkitt's lymphoma]],  [[cancer]],  [[leukemia]],  [[non Hodgkin's lymphoma]], [[pheochromocytoma]],
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 119: Line 115:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"|Severe[[ hypoxemia]] (PO2 <25 to 30 mmHg) , Severe [[asthma ]] , [[Respiratory failure]] , Lung disease - reduced oxygen intake , [[Hypoxia]]
|bgcolor="Beige"| [[Asthma]], [[hypercapnia]], [[hypoxia]], [[pulmonary edema]], [[respiratory failure]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"|Renal failure , [[Hemofiltration]]
|bgcolor="Beige"| [[Diabetic nephropathy]],  [[hemofiltration]], [[renal failure]]  
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Latent autoimmune diabetes]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 143: Line 139:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"|Succinic [[acidemia ]] , [[Strychnine]] , Severe [[exercise ]] , [[Reye's syndrome]] , Reduced [[oxygen]] utilization , Multiple organ dysfunction , Marked [[acidemia ]] , [[Intravenous pyelogram]] , [[Idiopathic]] , [[Hypothermic]] shivering , [[Hypoperfusion]] , [[Haemorrhage]] , Finnish lethal neonatal metabolic syndrome , Decreased [[oxygen]] delivery , Cuffed [[blood]] sample, [[Chronic fatigue syndrome]] , [[MERRF]] , [[MELAS]]
|bgcolor="Beige"|[[Chronic fatigue syndrome]], [[coenzyme Q10|coenzyme q10 deficiency]], [[exercise]], [[glycogen storage disease]], [[hypothermia]],  [[idiopathic]], [[malignant hyperpyrexia]],  [[mitochondrial toxicity]],  [[smoke inhalation]]
|-
|-
|}
|}
<font color="white">Causes by Organ System developed by WikiDoc.org, Copyleft 2013</font>


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
{{Multicol}}
{{col-begin|width=80%}}
*[[Abacavir]]
{{col-break|width=33%}}
*[[Abacavir]]
*[[Abacavir]]
*[[Acquired immune deficiency syndrome ]]
*[[Acquired immune deficiency syndrome]]
*[[Acute liver failure]]
*[[Acute liver failure]]
*Acute [[pulmonary edema ]]
*[[Adefovir]]
*[[Adefovir ]]
*[[Alcoholism]]
*[[Alcoholism ]]
*[[Anemia]]
*[[Ariboflavinosis]]
*[[Ariboflavinosis]]
*[[Asthma]]
*[[Atenolol]]
*[[Atenolol]]
*[[Bacterial overgrowth]] of small intestine
*[[Beriberi heart disease]]
*[[Beriberi Heart Disease]]
*[[Biguanide]]
*[[Biguanide]]
*[[Buformin]]
*[[Buformin]]
*[[Burkitt's lymphoma]]
*[[Burkitt's lymphoma]]
*[[Carbon monoxide poisoning ]]
*[[Cancer]]
*[[Carbon monoxide poisoning]]
*[[Carbon monoxide poisoning]]
*[[Cardiac arrest ]]
*[[Cardiac arrest]]
*[[Cardiac catheterization]]
*[[Cardiomyopathy ]]
*[[Cardiomyopathy ]]
*[[Chronic fatigue syndrome]]
*[[Chronic fatigue syndrome]]
*[[Coenzyme Q]] cytochrome c reductase deficiency
*[[Coenzyme Q cytochrome c reductase deficiency]]
*[[Coenzyme Q10]] deficiency
*[[Coenzyme Q10|Coenzyme Q10 deficiency]]
*Complications During and Following [[Cardiac Catheterization]]
*[[Contrast medium]]
*[[Contrast medium]]
*Copperhead snake [[poisoning ]]
*[[Cyanide poisoning]]
*Crotalidae snake [[poisoning ]]
*Cuffed blood sample
*[[Cyanide ]]intoxication
*[[Decreased activity  [[pyruvate carboxylase ]]
*[[Decreased activity of [[pyruvate dehydrogenase  ]]
*Decreased [[oxygen]] delivery 
*[[Diabetes mellitus]]
*[[Diabetic nephropathy]]
*[[Diabetic nephropathy]]
*[[Didanosine]]
*[[Didanosine]]
*Dihydrolipoamide dehydrogenase deficiency
*Dye-contrast medical tests - can cause LA by inhibiting the kidneys.
*[[Emtricitabine]]
*[[Entecavir]]
*[[Entecavir]]
*[[Ethanol]]
*[[Ethanol]]
*[[Ethylmalonic encephalopathy]]
*[[Ethylmalonic encephalopathy]]
*[[Exercise]]
*[[Fetal distress]]
*[[Fetal distress]]
*Finnish lethal neonatal [[metabolic syndrome ]]
*Fire
*[[Fructose intolerance]]
*[[Fructose intolerance]]
{{col-break|width=33%}}
*[[Fructose-1-phosphate aldolase deficiency]]
*[[Fructose-1-phosphate aldolase deficiency]]
*[[Fructose-1, 6-diphosphatase deficiency]]
*[[Fructose-1,6-diphosphatase deficiency]]
{{ColBreak}}
*[[Glycogen storage disease]]
*[[Fructose-1,6-bisphosphatase deficiency, hereditary ]]
*[[Glyburide]] and [[Metformin ]]
*[[Glycogen storage disease]] type 1C
*[[Glycogen storage disease]] type 1D
*[[Glycogen Storage Disease]] Type I
*[[Glycogenosis]] type 1a
*[[Glycogenosis]] type 1b
*[[GRACILE syndrome]]
*[[GRACILE syndrome]]
*[[Grand mal seizure ]]
*[[Grand mal seizure ]]
*[[Haemorrhage]]
*[[Hemorrhage]]
*[[Heart diseases]]
*[[Heart failure]]
*[[Hemofiltration]]
*[[Hemofiltration]]
*[[Hepatic failure]]
*[[Hepatic failure|Liver failure]]
*[[Holocarboxylase synthase deficiency]]
*[[Holocarboxylase synthase deficiency]]
*Hydroxyacyl-coa dehydrogenase, type 2, deficiency
*[[Hypercapnia]]
*[[Hypoglycemia]]
*[[Hypoglycemia]]
*[[Hypoperfusion]]
*[[Hypoperfusion]]
*Hypothermic shivering
*[[Hypothermia]]
*[[Hypovolemia]]
*[[Hypoxia]]
*[[Hypoxia]]
*[[Idiopathic]]
*[[Idiopathic]]
*Impaired [[pyruvate]] utilization
*[[Intestinal ischemia]]
*[[Intestinal ischaemia]]
*[[Intravenous pyelogram]]
*[[Intravenous pyelogram]]
*[[Isopropyl alcohol]]
*[[Isopropyl alcohol]]
*[[Lamivudine ]]
*[[Lamivudine]]
*[[Latent autoimmune diabetes]]
*[[Latent autoimmune diabetes]]
*[[Leukemia]]
*[[Linezolid]]
*[[Linezolid]]
*[[Liver disease]]
*[[Liver disease]]
*Lung disease - reduced [[oxygen]] intake
*Malignancy
*[[Malignant hyperpyrexia]]
*[[Malignant hyperpyrexia]]
*[[Malonyl-CoA decarboxylase deficiency]]
*[[Malonyl-CoA decarboxylase deficiency]]
*[[Malonyl-CoA decarboxylase deficiency]]
*Marked [[acidemia ]]
*Medium and long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
*[[MELAS]]
*[[MELAS]]
*[[MERRF]]
*[[MERRF]]
*[[Mesenteric ischemia]]
*[[Mesenteric ischemia]]
*[[Metabolic syndrome]]
*[[Metformin]]
*[[Metformin]]
*[[Mitochondrial]] aspartyl-tRNA synthetase deficiency
{{col-break|width=33%}}
*[[Mitochondrial]] DNA depletion syndrome
*[[Mitochondrial]] encephalomyopathy -- aminoacidopathy
*[[Mitochondrial]] genome inherited conditions
*[[Mitochondrial myopathy]]
*[[Mitochondrial myopathy]]
{{ColBreak}}
*[[Mitochondrial ]]neurogastrointestinal encephalopathy syndrome
*[[Mitochondrial toxicity]]
*[[Mitochondrial toxicity]]
*Multiple organ dysfunction syndrome
*[[Multiple organ dysfunction syndrome]]
*[[Myopathy]] with deficiency of succinate dehydrogenase and aconitase]]
*[[Myocardial infarction]]
*[[Non Hodgkin's lymphoma]]
*[[Non Hodgkin's lymphoma]]
*[[Oligohydramnios]]
*[[Paracetamol]]
*[[Paracetamol]]
*[[Phenformin]]
*[[Phenformin]]
*[[Pheochromocytoma ]]
*[[Pheochromocytoma]]
*Pyridoxine-5'-phosphate oxidase deficiency
*[[Pulmonary edema]]
*[[Pyruvate carboxylase]] deficiency
*[[Pyruvate carboxylase deficiency]]
*Pyruvate decarboxylase deficiency
*[[Pyruvate dehydrogenase deficiency]]
*[[Pyruvate dehydrogenase]] deficiency
*[[Renal failure]]
*[[Pyruvate dehydrogenase phosphatase deficiency ]]
*Reduced oxygen utilization
*[[Renal failure, chronic]]
*[[Respiratory failure]]
*[[Respiratory failure]]
*[[Reye's syndrome]]
*[[Reye's syndrome]]
*[[Salicylate intoxication ]]
*[[Salicylate intoxication]]
*SCHAD deficiency
*[[Seizures]]
*[[Sepsis]]
*[[Sepsis]]
*Severe [[asthma ]]
*Severe [[exercise ]]
*Severe [[hypoxemia]] (PO2 <25 to 30 mmHg)
*[[Shock]]
*[[Shock]]
*[[Short bowel syndrome]]
*[[Short bowel syndrome]]
*[[Smoke inhalation ]]
*[[Small bowel bacterial overgrowth syndrome]]
*[[ST Elevation Myocardial Infarction Complications]]
*[[Smoke inhalation]]
*[[ST elevation myocardial infarction complications]]
*[[Stavudine]]
*[[Stavudine]]
*[[Stribild]]
*[[Strychnine]]
*[[Strychnine]]
*Subacute necrotising [[encephalomyelopathy]]
*[[Telbivudine]]
*Succinic [[acidemia ]]
*[[Tenofovir]]
*Succinyl-CoA synthetase deficiency
*[[Thiamine deficiency]]
*[[Telbivudine ]]
*[[Tumors]]
*[[Tenofovir ]]
*[[Von Gierke disease]]
*Type 1 [[glycogen storage disease ]]
*Type I [[Glycogen Storage Disease ]]
*[[Von Gierke Disease ]]
*[[Zalcitabine]]
*[[Zalcitabine]]
*17- beta-hydroxysteroid dehydrogenase X deficiency
*[[Zidovudine]]
*3-Hydroxyacyl-CoA Dehydrogenase II Deficiency
{{col-end}}
*3-Hydroxyisobutyric aciduria
*3-methylglutaconic aciduria, type 4
{{EndMultiCol}}


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
 
[[Category:Crowdiagnosis]]
[[Category:Electrolyte disturbance]]
[[Category:Electrolyte disturbance]]
[[Category:Medical emergencies]]
[[Category:Medical emergencies]]

Latest revision as of 22:41, 8 December 2014

Lactic acidosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Lactic acidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Treatment

Medical Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Lactic acidosis causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Lactic acidosis causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Lactic acidosis causes

CDC on Lactic acidosis causes

Lactic acidosis causes in the news

Blogs on Lactic acidosis causes

Directions to Hospitals Treating Lactic acidosis

Risk calculators and risk factors for Lactic acidosis causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Lactic acidosis is one of the most common causes of high anion gap metabolic acidosis and is usually associated with a serum lactate levels above 4 mmol/L. Reduced oxygen tension shunts glycolysis towards pyruvate production, which in turn leads to lactate accumulation since pyruvate can no longer undergo aerobic metabolism.

Causes

Life Threatening Causes

Life-threatening causes include conditions which result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Cardiac arrest, cardiac catheterization, cardiomyopathy, heart failure, hemorrhage, hypoperfusion, hypovolemia, multiple organ dysfunction syndrome, myocardial infarction, shock, ST elevation myocardial infarction complications
Chemical/Poisoning Alcoholism, carbon monoxide poisoning, contrast medium, cyanide poisoning, ethanol, intravenous pyelogram, isopropyl alcohol
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Abacavir, adefovir, atenolol, biguanide, buformin, didanosine, emtricitabine, entecavir, Glyburide and Metformin, lamivudine, Linagliptin and Metformin hydrochloride, linezolid, metformin, paracetamol, phenformin, Repaglinide and Metformin hydrochloride, Reye's syndrome, salicylate intoxication, Saxagliptin hydrochloride and Metformin hydrochloride, stavudine, strychnine, telbivudine, tenofovir, zalcitabine, Zidovudine
Ear Nose Throat No underlying causes
Endocrine Diabetic nephropathy, hypoglycemia, latent autoimmune diabetes, metabolic syndrome
Environmental No underlying causes
Gastroenterologic Acute liver failure, intestinal ischemia, liver failure, mesenteric ischemia, short bowel syndrome, small bowel bacterial overgrowth
Genetic Fructose intolerance, fructose-1-phosphate aldolase deficiency, fructose-1,6-diphosphatase deficiency, glycogen storage disease, holocarboxylase synthase deficiency, MELAS, MERRF, mitochondrial myopathy, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency, von Gierke disease
Hematologic Anemia, Burkitt's lymphoma, leukemia, non Hodgkin's lymphoma
Iatrogenic Cardiac catheterization
Infectious Disease Acquired immune deficiency syndrome, sepsis, small bowel bacterial overgrowth
Musculoskeletal/Orthopedic No underlying causes
Neurologic Ethylmalonic encephalopathy, grand mal seizure, seizures
Nutritional/Metabolic Ariboflavinosis, beriberi heart disease, fructose intolerance, fructose-1-phosphate aldolase deficiency, fructose-1,6-diphosphatase deficiency, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency, thiamine deficiency
Obstetric/Gynecologic Fetal distress, oligohydramnios,
Oncologic Burkitt's lymphoma, cancer, leukemia, non Hodgkin's lymphoma, pheochromocytoma,
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Asthma, hypercapnia, hypoxia, pulmonary edema, respiratory failure
Renal/Electrolyte Diabetic nephropathy, hemofiltration, renal failure
Rheumatology/Immunology/Allergy Latent autoimmune diabetes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Chronic fatigue syndrome, coenzyme q10 deficiency, exercise, glycogen storage disease, hypothermia, idiopathic, malignant hyperpyrexia, mitochondrial toxicity, smoke inhalation

Causes by Organ System developed by WikiDoc.org, Copyleft 2013

Causes in Alphabetical Order

References


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Lactic_acidosis_causes&oldid=1046067"