Clebopride: Difference between revisions

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{{drugbox
{{Drugbox
| IUPAC_name       = 4-amino-''N''-(1-benzylpiperidin-4-yl)-5-chloro-<br>2-methoxybenzamide
| Watchedfields = changed
| image             = Clebopride.svg
| verifiedrevid = 437179173
| CAS_number        = 55905-53-8
| IUPAC_name = 4-amino-''N''-(1-benzylpiperidin-4-yl)-5-chloro-<br>2-methoxybenzamide
| ATC_prefix        = A03
| image = Clebopride.png
| ATC_suffix        = FA06
| image2 = Clebopride0.png
| PubChem          = 2780
 
| DrugBank          =
<!--Clinical data-->
| C=20|H=24|Cl=1|N=3|O=2
| tradename =
| molecular_weight  = 373.876 g/mol
| Drugs.com = {{drugs.com|international|clebopride}}
| bioavailability  =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| protein_bound    =
| pregnancy_US = <!-- A / B            / C / D / X -->
| metabolism        =
| pregnancy_category =   
| elimination_half-life =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| excretion        =
| legal_CA = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| pregnancy_AU     = <!-- A / B1 / B2 / B3 / C / D / X -->
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| pregnancy_US     = <!-- A / B            / C / D / X -->
| legal_US = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| pregnancy_category=   
| legal_status =
| legal_AU         = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| routes_of_administration =
| legal_CA         = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
 
| legal_UK         = <!-- GSL        / P      / POM / CD / Class A, B, C -->
<!--Pharmacokinetic data-->
| legal_US         = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| bioavailability = 
| legal_status     =  
| protein_bound = 
| routes_of_administration =  
| metabolism = 
| elimination_half-life = 
| excretion = 
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 55905-53-8
| ATC_prefix = A03
| ATC_suffix = FA06
| PubChem = 2780
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2678
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = I0A84520Y9
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D03534
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 325109
 
<!--Chemical data-->
| C=20 | H=24 | Cl=1 | N=3 | O=2
| molecular_weight = 373.876 g/mol
| smiles = Clc1cc(c(OC)cc1N)C(=O)NC3CCN(Cc2ccccc2)CC3
| InChI = 1/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25)
| InChIKey = BVPWJMCABCPUQY-UHFFFAOYAL
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = BVPWJMCABCPUQY-UHFFFAOYSA-N
}}
}}
__NOTOC__
{{SI}}
{{CMG}}
==Overview==
'''Clebopride''' is a [[dopamine antagonist]] drug with  [[antiemetic]] and [[prokinetic]] properties used to treat functional gastrointestinal disorders. Chemically, it is a [[substituent|substituted]] [[benzamide]], closely related to [[metoclopramide]].
'''Clebopride''' is a [[dopamine antagonist]] drug with  [[antiemetic]] and [[prokinetic]] properties used to treat functional gastrointestinal disorders. Chemically, it is a [[substituent|substituted]] [[benzamide]], closely related to [[metoclopramide]].


A small Spanish study found that more [[adverse drug reaction|adverse reaction]]s are reported with clebopride than with metoclopramide, particularly [[extrapyramidal symptoms]].<ref>{{cite journal |author=Cuena Boy R, Maciá Martínez MA |title=[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System] |language=Spanish |journal=Atencion Primaria |volume=21 |issue=5 |pages=289–95 |year=1998 |pmid=9608114 |doi=}} [http://www.doyma.es/cgi-bin/wdbcgi.exe/doyma/mrevista.fulltext?pident=15065 Free full text]</ref>
A small Spanish study found that more [[adverse drug reaction|adverse reaction]]s are reported with clebopride than with metoclopramide, particularly [[extrapyramidal symptoms]].<ref>{{cite journal |author=Cuena Boy R, Maciá Martínez MA |title=[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System] |language=Spanish |journal=Atencion Primaria |volume=21 |issue=5 |pages=289–95 |year=1998 |pmid=9608114 |doi=}} [http://www.elsevier.es/revistas/ctl_servlet?_f=7064&ip=95.136.62.252&articuloid=15065&revistaid=27 Free full text]</ref>


==References==
==References==
{{Reflist}}
{{Reflist|2}}
 
 


{{Drugs for functional gastrointestinal disorders}}
{{Drugs for functional gastrointestinal disorders}}


[[Category:Drugs]]
[[Category:Antiemetics]]
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[[Category:Dopamine antagonists]]
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[[Category:Piperidines]]
[[Category:Phenol ethers]]
[[Category:Organochlorides]]
[[Category:Drug]]

Latest revision as of 18:09, 10 April 2015

Clebopride
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC20H24ClN3O2
Molar mass373.876 g/mol
3D model (JSmol)
  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.[1]

References

  1. ↑ Cuena Boy R, Maciá Martínez MA (1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]". Atencion Primaria (in Spanish). 21 (5): 289–95. PMID 9608114. Free full text

Template:Drugs for functional gastrointestinal disorders

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