Aggressive NK-cell leukemia laboratory findings: Difference between revisions
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{{Aggressive NK-cell leukemia}} | {{Aggressive NK-cell leukemia}} | ||
{{CMG}} | {{CMG}} | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Leukemic cells are invariably present in samples of peripheral [[blood]] to a variable extent. [[Pancytopenia]] ([[anemia]], [[neutropenia]], [[thrombocytopenia]]) is commonly seen as well. | Leukemic cells are invariably present in samples of peripheral [[blood]] to a variable extent. [[Pancytopenia]] ([[anemia]], [[neutropenia]], [[thrombocytopenia]]) is commonly seen as well. | ||
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===Peripheral blood=== | ===Peripheral blood=== | ||
The leukemic cells have a diameter mildly greater than a [[large granular lymphocyte]] (LGL) and have azurophilic granules and nucleoli of varying prominence. Nuclei may be irregular and hyperchromatic. | The leukemic cells have a diameter mildly greater than a [[large granular lymphocyte]] (LGL) and have azurophilic granules and nucleoli of varying prominence. Nuclei may be irregular and hyperchromatic. | ||
===Bone marrow=== | ===Bone marrow=== | ||
Bone marrow involvement runs the spectrum between an inconspicuous infiltrate to extensive marrow replacement by leukemic cells. Reactive [[histiocytes]] displaying [[hemophagocytosis]] can been seen interspersed in the [[neoplastic]] infiltrate. | Bone marrow involvement runs the spectrum between an inconspicuous infiltrate to extensive marrow replacement by leukemic cells. Reactive [[histiocytes]] displaying [[hemophagocytosis]] can been seen interspersed in the [[neoplastic]] infiltrate. | ||
===Other organs=== | ===Other organs=== | ||
Leukemic involvement of organs is typically destructive on tissue sections with necrosis and possibly angioinvasion, and the monotonous infiltrate may be diffuse or patchy. | Leukemic involvement of organs is typically destructive on tissue sections with necrosis and possibly angioinvasion, and the monotonous infiltrate may be diffuse or patchy. | ||
==References== | ==References== | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Latest revision as of 14:17, 14 August 2015
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Aggressive NK-cell leukemia Microchapters |
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Differentiating Aggressive NK-cell leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Aggressive NK-cell leukemia laboratory findings On the Web |
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American Roentgen Ray Society Images of Aggressive NK-cell leukemia laboratory findings |
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Directions to Hospitals Treating Aggressive NK-cell leukemia |
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Risk calculators and risk factors for Aggressive NK-cell leukemia laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Laboratory Findings
Leukemic cells are invariably present in samples of peripheral blood to a variable extent. Pancytopenia (anemia, neutropenia, thrombocytopenia) is commonly seen as well.
Morphology
Peripheral blood
The leukemic cells have a diameter mildly greater than a large granular lymphocyte (LGL) and have azurophilic granules and nucleoli of varying prominence. Nuclei may be irregular and hyperchromatic.
Bone marrow
Bone marrow involvement runs the spectrum between an inconspicuous infiltrate to extensive marrow replacement by leukemic cells. Reactive histiocytes displaying hemophagocytosis can been seen interspersed in the neoplastic infiltrate.
Other organs
Leukemic involvement of organs is typically destructive on tissue sections with necrosis and possibly angioinvasion, and the monotonous infiltrate may be diffuse or patchy.