Mephenesin: Difference between revisions
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| IUPAC_name = 3-(2-methylphenoxy)propane-1,2-diol | | IUPAC_name = 3-(2-methylphenoxy)propane-1,2-diol | ||
| image = Mephenesin. | | image = Mephenesin.png | ||
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==Overview== | ==Overview== | ||
'''Mephenesin''' is a centrally acting [[muscle relaxant]]. It can be used as an [[antidote]] for [[strychnine poisoning]]. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low [[therapeutic index]]. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. | '''Mephenesin''' is a centrally acting [[muscle relaxant]]. It can be used as an [[antidote]] for [[strychnine poisoning]]. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low [[therapeutic index]]. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize [[meprobamate]], the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries. Its use has largely been replaced by the related drug [[methocarbamol]], which is better absorbed | ||
==See also== | ==See also== | ||
*[[Chlorphenesin]] | *[[Chlorphenesin]] | ||
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[[Category:Phenol ethers]] | [[Category:Phenol ethers]] | ||
[[Category:Alcohols]] | [[Category:Alcohols]] | ||
[[Category:Drug]] | [[Category:Drug]] | ||
Latest revision as of 16:40, 20 August 2015
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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| Formula | C10H14O3 |
| Molar mass | 182.216 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mephenesin is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries. Its use has largely been replaced by the related drug methocarbamol, which is better absorbed
See also
- Chlorphenesin
- Guaifenesin, a structurally-related compound used as an expectorant
- Mephenoxalone
- Methocarbamol
References
- Pages with script errors
- Template:drugs.com link with non-standard subpage
- Articles with changed CASNo identifier
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
- Chemical pages without DrugBank identifier
- Drugs with no legal status
- Drugboxes which contain changes to verified fields
- Muscle relaxants
- Phenol ethers
- Alcohols
- Drug