Mephenesin: Difference between revisions

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Mephenesin
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M03BX06 (WHO) ;
Identifiers
	IUPAC name 3-(2-methylphenoxy)propane-1,2-diol;
CAS Number	59-47-2 ;
PubChem CID	4059;
ChemSpider	3919 ;
UNII	7B8PIR2954;
KEGG	D02595 ;
ChEMBL	ChEMBL229128 ;
NIAID ChemDB	017830;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C10H14O3
Molar mass	182.216 g/mol
3D model (JSmol)	Interactive image;
	SMILES O(c1ccccc1C)CC(O)CO;
	InChI InChI=1S/C10H14O3/c1-8-4-2-3-5-10(8)13-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3 ; Key:JWDYCNIAQWPBHD-UHFFFAOYSA-N ;
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Latest revision as of 16:40, 20 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mephenesin is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries. Its use has largely been replaced by the related drug methocarbamol, which is better absorbed

References

@@ Line 49: / Line 49: @@
 {{CMG}}
 ==Overview==
-'''Mephenesin''' is a centrally acting [[muscle relaxant]]. It can be used as an [[antidote]] for [[strychnine poisoning]]. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low [[therapeutic index]]. It is especially dangerous and potentially fatal in combination with alcohol and other depressants.<ref>{{cite web|title=Mephenesin|url=https://www.mims.com/USA/drug/info/mephenesin/|publisher=MIMS}}</ref>  Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize [[meprobamate]], the first tranquilizer to see widespread clinical use.  Mephenesin is no longer available in North America but is used in France, Italy and a few other countries.<ref>{{cite web|title=Mephenesin|url=http://www.drugs.com/international/mephenesin.html|publisher=Drugs.com}}</ref> Its use has largely been replaced by the related drug [[methocarbamol]], which is better absorbed<ref>{{cite web|last=Huf|first=Ernst et al.|title=Comparative Plasma Levels of Mephenesin, Mephenesin Carbamate and Methocarbamol|url=http://ebm.sagepub.com/content/102/2/276.abstract|publisher=Experimental Biology & Medicine|accessdate=8 January 2014}}</ref>
+'''Mephenesin''' is a centrally acting [[muscle relaxant]]. It can be used as an [[antidote]] for [[strychnine poisoning]]. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low [[therapeutic index]]. It is especially dangerous and potentially fatal in combination with alcohol and other depressants.  Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize [[meprobamate]], the first tranquilizer to see widespread clinical use.  Mephenesin is no longer available in North America but is used in France, Italy and a few other countries. Its use has largely been replaced by the related drug [[methocarbamol]], which is better absorbed
 ==See also==
 *[[Chlorphenesin]]

v t e Skeletal Muscle relaxants (M03)
Peripherally acting (primarily antinicotinic, neuromuscular-blocking drugs)	Template:Navbox subgroup
Centrally Acting	Template:Navbox subgroup
Directly acting	Dantrolene

Mephenesin: Difference between revisions

Latest revision as of 16:40, 20 August 2015

Overview

See also

References

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