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| | {{Colorado tick fever}} |
| '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' | | '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' |
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| | species = '''Colorado tick fever virus''' | | | species = '''Colorado tick fever virus''' |
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| {{Colorado tick fever}}
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| {{About1|}} | | {{About1|}} |
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| ==[[Colorado tick fever overview|Overview]]== | | ==[[Colorado tick fever overview|Overview]]== |
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| ==[[Colorado tick fever historical perspective|Historical Perspective]]== | | ==[[Colorado tick fever historical perspective|Historical Perspective]]== |
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| ==[[Colorado tick fever pathophysiology|Pathophysiology]]== | | ==[[Colorado tick fever pathophysiology|Pathophysiology]]== |
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| ==[[Colorado tick fever causes|Causes]]== | | ==[[Colorado tick fever causes|Causes]]== |
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| ==[[Colorado tick fever differential diagnosis|Differentiating Colorado tick fever from other Diseases]]== | | ==[[Colorado tick fever differential diagnosis|Differentiating Colorado tick fever from other Diseases]]== |
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| ==[[Colorado tick fever epidemiology and demographics|Epidemiology and Demographics]]== | | ==[[Colorado tick fever epidemiology and demographics|Epidemiology and Demographics]]== |
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| ==[[Colorado tick fever risk factors|Risk Factors]]== | | ==[[Colorado tick fever risk factors|Risk Factors]]== |
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| ==[[Colorado tick fever natural history, complications and prognosis|Natural History, Complications and Prognosis]]== | | ==[[Colorado tick fever natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
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| ==Diagnosis== | | ==Diagnosis== |
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| [[Colorado tick fever case study one|Case #1]] | | [[Colorado tick fever case study one|Case #1]] |
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| [[Category:Parasitic diseases]]
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| [[Category:Apicomplexa]]
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| [[Category:Infectious disease]]
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| [[Category:Disease]]
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| '''Colorado Tick Fever (CTF)''' (also called ''Mountain tick fever'', ''Mountain fever'', and ''American mountain fever'') is an acute viral infection transmitted from the bite of an infected wood tick (''Dermacentor andersoni''). It should not be confused with the bacterial tick-borne infection, [[Rocky Mountain Spotted Fever]]. The [[type (biology)|type]] [[species]] of the [[genus]] ''[[Coltivirus]]'', Colorado tick fever virus (CTFV) infects haemopoietic cells, particularly [[erythrocyte]]s, which explains how the virus is trasmitted by bloodsucking ticks and also accounts for the incidence of transmission via blood transfusion. The disease develops from March to September, with the highest infections occurring in May and June. [http://www.nlm.nih.gov/medlineplus/print/ency/article/000675.htm] The disease is found almost exclusively in the western United States and Canada, mostly in high mountain areas such as Colorado and Idaho. The CTFV was first isolated from human blood in 1944. [http://www.oregon.gov/DHS/ph/acd/diseases/ctf/facts.shtml]
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| The virus particle, like other Coltiviruses, is ~80 nm in diameter and is generally non-envolped. The double stranded RNA viral genome is ~20,000bp long and is divided into 12 segments, which are termed Seg-1 to Seg-12. Viral replication in infected cells is associated with characteristic cytoplasmic granular matrices. Evidence suggests that viral presence in mature erythrocytes is a result of replication of the virus in hematopoitic erythrocyte precursor cells and simultaneous maturation of the infected immature cells rather than off direct entry and replication of CTFV in mature erythrocytes.[http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240408]
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| The wood tick is usually found attached to a host, but when it is without a host it hides in cracks and crevices as well as soil. If for some reason the tick is not able to find a host before the winter months, it will stay under groundcover until spring when it can resume its search. The wood tick typically does not seek out available hosts in the hottest summer months as well. Adult ticks, for the most part, tend to climb to the top of grass and low shrubs to attach themselves to a host that is wandering by. These ticks are able to attach to their hosts by secreting a cement-like substance from their mouths and inserting it into the host.[http://www.answers.com/topic/rocky-mountain-wood-tick]
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| ==Transmission==
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| Colorado Tick Fever is acquired by tick bite. There is no evidence of natural person-to-person transmission. However, rare cases of transmission from [[blood transfusion]]s have been reported. The virus which causes Colorado Tick Fever may stay in the blood for as long as four months after onset of the illness.
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| ==Symptoms==
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| ==Diagnosis==
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| A combination of clinical signs, symptoms and laboratory tests can confirm the likely hood of having CTF. Some tests include complement fixation to Colorado tick virus, Immunofluoresence for Colorado tick fever, and some other common laboratory findings suggestive of CTF including leucopenia, thrombocytopenia, and mildly elevated liver enzyme levels.
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| At this time there is no specific treatment for CTF. The first thing to do is make sure the tick is fully removed from the skin, then Acetaminophen and analgesics can be used to help relieve the fever and pain. Aspirin is not recommended for children it has been linked to Reye’s syndrome in some viral illnesses. Salicylates should not be used because of thrombocytopenia, and the rare occurrence of bleeding disorders. Someone who suspects that they have been bitten by a tick or is starting to show signs of CTF should contact their physician immediately.[http://www.nlm.nih.gov/medlineplus/print/ency/article/000675.htm]
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| ==Prevention==
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| To avoid tick bites and infection, experts advise:
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| *Avoid tick infested areas, especially during the warmer months.
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| *Wear light colored clothing so ticks can be easily seen. Wear a long sleeved shirt, hat, long pants, and tuck pant legs into socks.
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| *Walk in the center of trails to avoid overhanging grass and brush.
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| *Check your body every few hours for ticks when you spend a lot of time outdoors in tick infested areas. Ticks are most often found on the thigh, arms, underarms and legs. Ticks can be very small (no bigger than a pinhead). Look carefully for new "freckles".
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| *Use [[insect repellent]]s containing [[DEET]] on your skin or [[permethrin]] on clothing. Be sure to follow the directions on the container and wash off repellents when going indoors.
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| *Remove attached ticks immediately.
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| Contacting the CTF virus is thought to provide long lasting immunity against reinfection. However it is always wise to be on the safe side and try to prevent tick bites.[http://www.oregon.gov/DHS/ph/acd/diseases/ctf/facts.shtml]
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| ==Gallery==
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| <gallery>
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| Image: Colorado tick fever10.jpeg| Long-tailed weasel, Mustela frenata, is a carrier of plague vectors. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever09.jpeg| SEM provides a closer view of this male Dermacentor sp. tick found upon a cat (95x mag). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever08.jpeg| SEM provides a closer view of this male Dermacentor sp. tick found upon a cat (3862x mag). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever07.jpeg| SEM image depicts a dorsal view of an unidentified engorged female tick, which had been extracted from the skin of a pet cat (26x mag). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever06.jpeg| SEM image depicted a dorsal view of an unidentified engorged female tick which had been extracted from the skin of a pet cat while in the process of obtaining its blood meal (52x mag). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever05.jpeg| TEM reveals some of the morphologic details displayed by the Colorado tick fever virus (CTFV). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever04.jpeg| TEM reveals some of the morphologic details displayed by the Colorado tick fever virus (CTFV). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever03.jpeg| TEM revealed the presence of numerous Reovirus type-3 virions. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| Image: Colorado tick fever01.jpeg| Columbian ground squirrel, Urocitellus columbianus, is infested by numerous nymphal-staged D. andersoni ticks, the vector responsible for transmitting the Coltivirus, Colorado tick fever (CTF) to humans. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
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| </gallery>
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| ==References==
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| * {{cite journal|last=Attoui|first=H|coauthors=Billoir F; Biagini P; Cantaloube JF; de Chesse R; de Micco P; de Lamballerie X|title=Sequence determination and analysis of the full-length genome of Colorado tick fever virus, the type species of genus Coltivirus (Family Reoviridae)|journal=Biochem Biophys Res Commun|date=2000-07-14|volume=273|issue=3|pages=1121-5}}
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| * {{cite journal|last=Attoui|first=H|coauthors=Jaafar, FM; de Micco, P; de Lamballerie, X.|title=Coltiviruses and seadornaviruses in North America, Europe, and Asia|journal=Emerg Infect Dis.|year=2005|month=Nov|volume=11|issue=11|pages=1673-9}}
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| * {{cite book|last=Edlow|first=A|coauthors=Jonathan, MD|title=Tick-Borne Diseases|location=Colorado|year=2005|accessdate=2006-10-08|url=http://www.emedicine.com/EMERG/topic586.htm}}
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| * {{cite journal|last=Leiby|first=DA|coauthors=Gill, JE.|title=Transfusion-transmitted tick-borne infections: a cornucopia of threats|journal=Transfus Med Rev.|year=2004|month=Oct|volume=18|issue=4|pages=293-306}}
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| * {{cite journal|last=Phillip|first=Claire S.|coauthors=et al.|title=Replication of Colorado tick fever virus within human hematopoietic progenitor cells.|journal=Journal of Virology|volume=67|issue=4|year=1993|pages=2389-2395|url=http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240408}}
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| * {{cite book|last=Smith|first=Scott D., M.D.,MSc,DTM&H.|title=Medical Encyclopedia: Colorado tick fever|year=2006|accessdate=2006-10-08|url=http://www.nlm.nih.gov/medlineplus/print/ency/article/ooo675.htm}}
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| *{{cite web|title=Acute and Communicable Disease Prevention|url=http://www.oregon.gov/DHS/ph/acd/diseases/ctf/facts.shtml}}
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| * {{cite web|title=Rocky Mountain wood tick|url=http://www.answers.com/topic/rocky-mountain-wood-tick}}
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