Diffuse panbronchiolitis: Difference between revisions

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{{Diffuse panbronchiolitis}}
{{Diffuse panbronchiolitis}}


{{CMG}}
{{CMG}} {{AE}}


==Overview==
{{SK}} Panbronchiolitis; DPB


==[[Diffuse panbronchiolitis overview|Overview]]==


==[[Diffuse panbronchiolitis historical perspective|Historical Perspective]]==


[[Image:diagrama de los pulmones.svg|thumb|left|330px|A simple diagram of the [[respiratory system]]: 1. [[trachea]], 2. [[pulmonary artery]], 3. [[pulmonary vein]], 4. [[alveolar duct]], 5. [[alveolus|alveoli]], 6. [[cardiac notch]], 7. '''[[bronchiole]]''', 8. [[tertiary bronchus|tertiary bronchi]], 9. [[secondary bronchus|secondary bronchi]], 10. [[bronchus|primary bronchi]], 11. [[larynx]] ]]
==[[Diffuse panbronchiolitis classification|Classification]]==


== Prevalence ==
==[[Diffuse panbronchiolitis pathophysiology|Pathophysiology]]==


== Symptoms ==
==[[Diffuse panbronchiolitis causes|Causes]]==


== Pathogenesis ==
==[[Diffuse panbronchiolitis differential diagnosis|Differentiating Diffuse panbronchiolitis from other Diseases]]==


== Treatment ==
==[[Diffuse panbronchiolitis epidemiology and demographics|Epidemiology and Demographics]]==


[[Macrolide]] [[antibiotic]]s, such as [[erythromycin]], [[clarithromycin]] and [[roxithromycin]], have proven to be an effective long-term treatment for DPB.<ref name=mac>{{cite journal |author=Keicho N, Kudoh S |title=Diffuse panbronchiolitis: role of macrolides in therapy |journal=Am J Respir Med. |volume=1 |issue=2 |pages=119-131 |year=2002 |pmid=14720066 }}</ref><ref name=mac08>{{cite journal |author=Lopez-Boado YS, Rubin BK |title=Macrolides as immunomodulatory medications for the therapy of chronic lung diseases |journal=Curr Opin Pharmacol. |volume=Epub ahead of print |issue= |pages= |year=2008 |pmid=18339582 }}</ref> The successful results of macrolides in DPB and similar lung diseases stems from controlling symptoms through [[immunomodulation]] (adjusting the immune response),<ref name=mac08/> with the added benefit of [[dosing|low-dose]] requirements.<ref name=mac/>
==[[Diffuse panbronchiolitis risk factors|Risk Factors]]==


With macrolide therapy in DPB, great reduction in bronchiolar inflammation and damage is achieved through suppression of not only neutrophil granulocyte proliferation, but also lymphocyte activity and obstructive [[mucus]] and sputum [[secretion]]s in airways.<ref name=mac/> The antimicrobial and antibiotic effects of macrolides, however, are not believed to be involved in their beneficial effects toward treating DPB.<ref name=mac04>{{cite journal |author=Schultz MJ |title=Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis |journal=J Antimicrob Chemother. |volume=54 |issue=1 |pages=21-28 |year=2004 |pmid=15190022 }}</ref> This is evident, as the treatment dosage is much too low to fight infection, and in DPB cases with the occurrence of macrolide-resistant ''pseudomonas aeruginosa'', macrolide therapy still produces substantial anti-inflammatory results.<ref name=mac/>
==[[Diffuse panbronchiolitis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


Advanced cases of DPB, where severely excessive sputum production  resistant to macrolides persists, additional therapy with the inhalant [[tiotropium]] has been shown to ease these symptoms and the related shortness of breath.<ref name=tio>{{cite journal |author=Saito Y, Azuma A, Morimoto T, Fujita K, Abe S, Motegi T, Usuki J, Kudoh S |title=Tiotropium ameliorates symptoms in patients with chronic airway mucus hypersecretion which is resistant to macrolide therapy |journal=Intern Med. |volume=47 |issue=7 |pages=585-591 |year=2008 |pmid=18379141 }}</ref>
==Diagnosis==
[[Diffuse panbronchiolitis history and symptoms|History and Symptoms]] | [[Diffuse panbronchiolitis physical examination|Physical Examination]] | [[Diffuse panbronchiolitis laboratory findings|Laboratory Findings]] | [[Diffuse panbronchiolitis chest x ray|Chest X Ray]] | [[Diffuse panbronchiolitis CT|CT]] | [[Diffuse panbronchiolitis MRI|MRI]] | [[Diffuse panbronchiolitis other imaging findings|Other Imaging Findings]] | [[Diffuse panbronchiolitis other diagnostic studies|Other Diagnostic Studies]]


== See also ==
==Treatment==
*[[Pulmonology]]
[[Diffuse panbronchiolitis medical therapy|Medical Therapy]] | [[Diffuse panbronchiolitis primary prevention|Primary Prevention]]  | [[Diffuse panbronchiolitis secondary prevention|Secondary Prevention]] | [[Diffuse panbronchiolitis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Diffuse panbronchiolitis future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Diffuse panbronchiolitis case study one|Case #1]]
 
==Related Chapters==
*[[Asthma]]
*[[Bronchitis]]
*[[Bronchitis]]
*[[Asthma]]
*[[Emphysema]]
*[[Emphysema]]
*[[Pulmonology]]


== References ==
{{reflist|2}}
<br />


{{Respiratory pathology}}
{{Respiratory pathology}}
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[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Rare diseases]]
[[Category:Rare diseases]]
[[Category:Disease]]


{{jb1}}
{{WikiDoc Help Menu}}
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{{WikiDoc Sources}}
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Latest revision as of 14:20, 6 June 2016

Diffuse panbronchiolitis
ICD-10 J21.9
ICD-9 466.1
OMIM 604809
DiseasesDB 3804

Diffuse panbronchiolitis Microchapters

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Overview

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Epidemiology and Demographics

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Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Synonyms and keywords: Panbronchiolitis; DPB

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Diffuse panbronchiolitis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

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Case #1

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