Growth hormone deficiency diagnostic criteria: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
 
(6 intermediate revisions by 3 users not shown)
Line 2: Line 2:
{{Growth hormone deficiency}}
{{Growth hormone deficiency}}
{{CMG}}
{{CMG}}
'''For patient information, click [[Growth hormone deficiency (patient information)|here]]'''
 
==Overview==
==Overview==
 
The diagnosis of growth hormone deficiency is based on the direct hormonal criteria, indirect hormonal criteria and radiological evidence of response to GH treatment.
Although GH can be readily measured in a blood sample, testing for GH deficiency is constrained by the fact that levels are nearly undetectable for most of the day. This makes simple measurement of GH in a single blood sample useless for detecting deficiency. Physicians therefore use a combination of indirect and direct criteria.


==Diagnostic Criteria==
==Diagnostic Criteria==
* Diagnosis of growth hormone deficiency is a subject of debate due to high costs and complexity of investigations.
* Several types of evidence are used to diagnose GH deficiency:
**Body measurements. GH deficiency accounts for only a minority of [[short stature]] among children.
**Indirect [[hormonal]] criteria ([[IGF]] levels)
**Direct [[hormonal]] criteria (secretory patterns of [[Growth hormone|GH levels]] or responses to [[Growth hormone|GH]] stimulation tests)
**Response to [[Growth hormone|GH treatment]]
**Radiological evidence of [[Pituitary disease|pituitary dysfunction]] 
* Many children and adults may not meet all the diagnostic criteria.
* An ideal [[diagnostic test]] cleanly separates people who would benefit from a treatment from those who would not.


Several types of evidence are used to ascertain GH sufficiency or deficiency.
== References ==
* Auxologic criteria (defined by body measurements)
{{Reflist|2}}
* Indirect hormonal criteria (IGF levels from a single blood sample)
* Direct hormonal criteria (measurement of GH in multiple blood samples to determine secretory patterns or responses to provocative testing)
* Response to GH treatment
* Corroborative evidence of pituitary dysfunction
 
For GH deficiency, as for many other diseases, the practical purpose and effect of these diagnostic criteria is to determine who is to be treated with it. GH deficiency accounts for only a minority of [[short stature]] among children. GH deficiency accounts for an even smaller proportion of [[Fatigue (physical)|fatigability]], [[obesity|excessive fat]], [[osteoporosis|osteopenic bones]], and underdeveloped muscles in adults.  An ideal [[diagnostic test]] cleanly separates people who would benefit from a treatment from those who would not. Unfortunately, none of the criteria listed above do so, not even in various combinations.
 
The common clinical problem is that many children and adults being evaluated meet some, but not all, of the above criteria. Since many children and adults who do not meet all of the diagnostic criteria may receive some of the benefits of treatment, small differences in the diagnostic criteria make large differences in the number of short or tired people diagnosed with deficiency.


Because of uncertainties and complexities of diagnosis and the high costs of treatment, diagnosis of growth hormone deficiency has been a more persistent subject of debate and controversy in clinical endocrinology than any other aspect of endocrine diagnosis. It has become a major type of internet fraud ([[HGH quackery]]).
==References==
{{reflist|2}}
{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Disease]]
[[Category:Endocrinology]]

Latest revision as of 22:08, 11 October 2017

Growth hormone deficiency Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Growth hormone deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Growth hormone deficiency diagnostic criteria On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Growth hormone deficiency diagnostic criteria

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Growth hormone deficiency diagnostic criteria

CDC on Growth hormone deficiency diagnostic criteria

Growth hormone deficiency diagnostic criteria in the news

Blogs on Growth hormone deficiency diagnostic criteria

Directions to Hospitals Treating Growth hormone deficiency

Risk calculators and risk factors for Growth hormone deficiency diagnostic criteria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The diagnosis of growth hormone deficiency is based on the direct hormonal criteria, indirect hormonal criteria and radiological evidence of response to GH treatment.

Diagnostic Criteria

  • Diagnosis of growth hormone deficiency is a subject of debate due to high costs and complexity of investigations.
  • Several types of evidence are used to diagnose GH deficiency:
  • Many children and adults may not meet all the diagnostic criteria.
  • An ideal diagnostic test cleanly separates people who would benefit from a treatment from those who would not.

References

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Growth_hormone_deficiency_diagnostic_criteria&oldid=1373241"