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{{Growth hormone deficiency}}
{{Growth hormone deficiency}}
{{CMG}}
{{CMG}}
'''For patient information, click [[Growth hormone deficiency (patient information)|here]]'''
 
==Overview==
==Overview==
*The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
The diagnosis of growth hormone deficiency is based on the direct hormonal criteria, indirect hormonal criteria and radiological evidence of response to GH treatment.
*The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
*The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
OR
*There are no established criteria for the diagnosis of [disease name].
 
==Diagnostic Criteria==
 
Several types of evidence are used to ascertain GH sufficiency or deficiency.
* Auxologic criteria (defined by body measurements)
* Indirect hormonal criteria (IGF levels from a single blood sample)
* Direct hormonal criteria (measurement of GH in multiple blood samples to determine secretory patterns or responses to provocative testing)
* Response to GH treatment
* Corroborative evidence of pituitary dysfunction
 
For GH deficiency, as for many other diseases, the practical purpose and effect of these diagnostic criteria is to determine who is to be treated with it. GH deficiency accounts for only a minority of [[short stature]] among children. GH deficiency accounts for an even smaller proportion of [[Fatigue (physical)|fatigability]], [[obesity|excessive fat]], [[osteoporosis|osteopenic bones]], and underdeveloped muscles in adults.  An ideal [[diagnostic test]] cleanly separates people who would benefit from a treatment from those who would not. Unfortunately, none of the criteria listed above do so, not even in various combinations.
 
The common clinical problem is that many children and adults being evaluated meet some, but not all, of the above criteria. Since many children and adults who do not meet all of the diagnostic criteria may receive some of the benefits of treatment, small differences in the diagnostic criteria make large differences in the number of short or tired people diagnosed with deficiency.
 
Because of uncertainties and complexities of diagnosis and the high costs of treatment, diagnosis of growth hormone deficiency has been a more persistent subject of debate and controversy in clinical endocrinology than any other aspect of endocrine diagnosis. It has become a major type of internet fraud ([[HGH quackery]]).
 
 


==Diagnostic Criteria==
==Diagnostic Criteria==
*The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met:  
* Diagnosis of growth hormone deficiency is a subject of debate due to high costs and complexity of investigations.
**[criterion 1]
* Several types of evidence are used to diagnose GH deficiency:
**[criterion 2]
**Body measurements. GH deficiency accounts for only a minority of [[short stature]] among children.
**[criterion 3]
**Indirect [[hormonal]] criteria ([[IGF]] levels)
**[criterion 4]
**Direct [[hormonal]] criteria (secretory patterns of [[Growth hormone|GH levels]] or responses to [[Growth hormone|GH]] stimulation tests)
*The diagnosis of [disease name] is based on the [criteria name] criteria, which include
**Response to [[Growth hormone|GH treatment]]
**[criterion 1]
**Radiological evidence of [[Pituitary disease|pituitary dysfunction]]
**[criterion 2]
* Many children and adults may not meet all the diagnostic criteria.
**[criterion 3]
* An ideal [[diagnostic test]] cleanly separates people who would benefit from a treatment from those who would not.  
*The diagnosis of [disease name] is based on the [definition name] definition, which includes
**[criterion 1]
**[criterion 2]
**[criterion 3]
OR
*There are no established criteria for the diagnosis of [disease name].


==References==
== References ==
{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 22:08, 11 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The diagnosis of growth hormone deficiency is based on the direct hormonal criteria, indirect hormonal criteria and radiological evidence of response to GH treatment.

Diagnostic Criteria

  • Diagnosis of growth hormone deficiency is a subject of debate due to high costs and complexity of investigations.
  • Several types of evidence are used to diagnose GH deficiency:
  • Many children and adults may not meet all the diagnostic criteria.
  • An ideal diagnostic test cleanly separates people who would benefit from a treatment from those who would not.

References

Template:WH Template:WS

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