Pseudohypoparathyroidism laboratory findings: Difference between revisions
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{{Pseudohypoparathyroidism}} | {{Pseudohypoparathyroidism}} | ||
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==Overview== | ==Overview== | ||
The diagnosis of pseudohypoparathyroidism is made by measurement of variations in serum [[calcium]], [[phosphorus]], [[cAMP]] and [[calcitriol]] and in urinary [[Cyclic adenosine monophosphate|cAMP]] and [[phosphorus]] excretion helps in assessment of skeletal and renal responsiveness to [[parathyroid]] hormone. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
* [[Hypocalcemia]] | *The diagnosis of pseudohypoparathyroidism is made by measurement of variations in serum [[calcium]], [[phosphorus]], [[cAMP]] and [[calcitriol]] and in urinary [[Cyclic adenosine monophosphate|cAMP]] and [[phosphorus]] excretion helps in assessment of skeletal and renal responsiveness to [[parathyroid]] hormone <ref name="pmid18663313">{{cite journal |vauthors=Shalitin S, Davidovits M, Lazar L, Weintrob N |title=Clinical heterogeneity of pseudohypoparathyroidism: from hyper- to hypocalcemia |journal=Horm. Res. |volume=70 |issue=3 |pages=137–44 |year=2008 |pmid=18663313 |doi=10.1159/000137658 |url=}}</ref> | ||
* [[Hyperphosphatemia]] | *Laboratory findings consistent with the diagnosis of pseudohypoparathyroidism include | ||
* Elevated [[parathyroid hormone]] | **[[Hypocalcemia]] | ||
**[[Hyperphosphatemia]] | |||
**Elevated serum concentration of [[parathyroid hormone]] | |||
**Diminished urinary [[cAMP]] response after administration of the biosynthetic N-terminal fragment of [[parathyroid]] hormone | |||
**[[Secondary hyperparathyroidism]] and [[hyperparathyroid]] bone disease due to the [[parathyroid]] hormone resistance | |||
*Immunoradiometric assay (IRMA) can be used to measure serum [[parathyroid]] hormone concentration | |||
*Assessment of [[thyroid function tests]], [[gonadotropin]], [[testosterone]], [[estrogen]] and insulin like growth factor will help in identification of any associated underlying hormonal dysfunction | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Nephrology]] | [[Category:Nephrology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
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Latest revision as of 19:15, 17 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
Overview
The diagnosis of pseudohypoparathyroidism is made by measurement of variations in serum calcium, phosphorus, cAMP and calcitriol and in urinary cAMP and phosphorus excretion helps in assessment of skeletal and renal responsiveness to parathyroid hormone.
Laboratory Findings
- The diagnosis of pseudohypoparathyroidism is made by measurement of variations in serum calcium, phosphorus, cAMP and calcitriol and in urinary cAMP and phosphorus excretion helps in assessment of skeletal and renal responsiveness to parathyroid hormone [1]
- Laboratory findings consistent with the diagnosis of pseudohypoparathyroidism include
- Hypocalcemia
- Hyperphosphatemia
- Elevated serum concentration of parathyroid hormone
- Diminished urinary cAMP response after administration of the biosynthetic N-terminal fragment of parathyroid hormone
- Secondary hyperparathyroidism and hyperparathyroid bone disease due to the parathyroid hormone resistance
- Immunoradiometric assay (IRMA) can be used to measure serum parathyroid hormone concentration
- Assessment of thyroid function tests, gonadotropin, testosterone, estrogen and insulin like growth factor will help in identification of any associated underlying hormonal dysfunction
References
- ↑ Shalitin S, Davidovits M, Lazar L, Weintrob N (2008). "Clinical heterogeneity of pseudohypoparathyroidism: from hyper- to hypocalcemia". Horm. Res. 70 (3): 137–44. doi:10.1159/000137658. PMID 18663313.