Antifibrinolytic: Difference between revisions
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'''Antifibrinolytics''', such as [[aminocaproic acid]] (ε-aminocaproic acid) and [[tranexamic acid]] are used as inhibitors of [[fibrinolysis]], which act by blocking the [[lysine]]-binding site on [[plasmin]]. | '''Antifibrinolytics''', such as [[aminocaproic acid]] (ε-aminocaproic acid) and [[tranexamic acid]] are used as inhibitors of [[fibrinolysis]], which act by blocking the [[lysine]]-binding site on [[plasmin]]. | ||
Tranexamic acid may reduce bleeding after orthopedic surgery<ref name="pmid29016673">{{cite journal| author=Sun Y, Jiang C, Li Q| title=A systematic review and meta-analysis comparing combined intravenous and topical tranexamic acid with intravenous administration alone in THA. | journal=PLoS One | year= 2017 | volume= 12 | issue= 10 | pages= e0186174 | pmid=29016673 | doi=10.1371/journal.pone.0186174 | pmc=5634626 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29016673 }} </ref>. [[Tranexamic acid]] may better than [[aminocaproic acid]] for reducing estimated blood loss in orthopedic surgery<ref name="pmid28976426">{{cite journal| author=Boese CK, Centeno L, Walters RW| title=Blood Conservation Using Tranexamic Acid Is Not Superior to Epsilon-Aminocaproic Acid After Total Knee Arthroplasty. | journal=J Bone Joint Surg Am | year= 2017 | volume= 99 | issue= 19 | pages= 1621-1628 | pmid=28976426 | doi=10.2106/JBJS.16.00738 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28976426 }} </ref>. | |||
Tranexamic acid may reduce bleeding after trauma<ref name="pmid25956410">{{cite journal| author=Ker K, Roberts I, Shakur H, Coats TJ| title=Antifibrinolytic drugs for acute traumatic injury. | journal=Cochrane Database Syst Rev | year= 2015 | volume= | issue= 5 | pages= CD004896 | pmid=25956410 | doi=10.1002/14651858.CD004896.pub4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25956410 }} </ref>. | |||
They are used in [[menorrhagia]] and bleeding tendency due to various causes. | They are used in [[menorrhagia]] and bleeding tendency due to various causes. | ||
==References== | |||
{{reflist|2}} | |||
==External links== | ==External links== | ||
Latest revision as of 17:40, 7 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Antifibrinolytics, such as aminocaproic acid (ε-aminocaproic acid) and tranexamic acid are used as inhibitors of fibrinolysis, which act by blocking the lysine-binding site on plasmin.
Tranexamic acid may reduce bleeding after orthopedic surgery[1]. Tranexamic acid may better than aminocaproic acid for reducing estimated blood loss in orthopedic surgery[2].
Tranexamic acid may reduce bleeding after trauma[3].
They are used in menorrhagia and bleeding tendency due to various causes.
References
- ↑ Sun Y, Jiang C, Li Q (2017). "A systematic review and meta-analysis comparing combined intravenous and topical tranexamic acid with intravenous administration alone in THA". PLoS One. 12 (10): e0186174. doi:10.1371/journal.pone.0186174. PMC 5634626. PMID 29016673.
- ↑ Boese CK, Centeno L, Walters RW (2017). "Blood Conservation Using Tranexamic Acid Is Not Superior to Epsilon-Aminocaproic Acid After Total Knee Arthroplasty". J Bone Joint Surg Am. 99 (19): 1621–1628. doi:10.2106/JBJS.16.00738. PMID 28976426.
- ↑ Ker K, Roberts I, Shakur H, Coats TJ (2015). "Antifibrinolytic drugs for acute traumatic injury". Cochrane Database Syst Rev (5): CD004896. doi:10.1002/14651858.CD004896.pub4. PMID 25956410.
External links
- Antifibrinolytics at the US National Library of Medicine Medical Subject Headings (MeSH)
- Template:MeshPharmaList