Gliomatosis cerebri: Difference between revisions

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Latest revision as of 01:45, 27 November 2017

For patient information click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Synonyms and keywords: Infiltrative diffuse astrocytosis; astrocytosis cerebri; glioblastosis cerebri; GC; diffuse gliomatosis; glioblastosis; central diffuse schwannosis; diffuse glioma of the brain; diffuse glioma of brain; gliomatous hypertrophy; blastomatous type of diffuse sclerosis; gliomatosis diffusa; glioblastoma multiforme; astrocytoma; brain tumor

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gliomatosis cerebri from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Treatment

Case Studies

Case#1

References

Template:Nervous tissue tumors

Template:WikiDoc Sources

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+{{Gliomatosis cerebri}}
 '''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.
-{{Infobox_Disease |
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-==Overview==
+{{SK}} Infiltrative diffuse astrocytosis; astrocytosis cerebri; glioblastosis cerebri; GC; diffuse gliomatosis; glioblastosis; central diffuse schwannosis; diffuse glioma of the brain; diffuse glioma of brain; gliomatous hypertrophy; blastomatous type of diffuse sclerosis; gliomatosis diffusa; glioblastoma multiforme; astrocytoma; brain tumor
-'''Gliomatosis cerebri (infiltrative diffuse astrocytosis)''' is a rare primary [[brain tumor]]. It is commonly characterized by diffuse infiltration of the brain with neoplastic [[glial cells]] that affect various areas of the cerebral lobes<ref>http://rad.usuhs.mil/medpix/radpix.html?mode=single&comebackto=mode%3Dgeo_browse&recnum=923</ref>.
-While gliomatosis cerebri can occur at any age, it is generally found in the third and fourth decades of life. It may affect any part of the [[brain]] or even the [[spinal cord]], [[optic nerve]] and compact [[white matter]]. Clinical manifestations are indefinite, and include [[headache]], [[seizures]], visual disturbances, [[corticospinal tract]] deficits, [[lethargy]], and [[dementia]].
+==[[Gliomatosis cerebri overview|Overview]]==
-Before the advent of [[MRI]], diagnosis was generally not established until [[autopsy]]. Even with MRI, however, diagnosis is difficult.<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10696026&dopt=Abstract</ref> Typically, gliomatosis cerebri appears as a diffuse, poorly circumscribed, infiltrating non-enhancing lesion that is hyperintense on T2-weighted images and expands the cerebral white matter. It is difficult to distinguish from highly infiltrate anaplastic astrocytoma or [[Glioblastoma multiforme|GBM]].<ref>http://www.urmc.rochester.edu/smd/Rad/neurocases/Neurocase01.htm</ref> The prognosis for gliomatosis cerebri is generally poor, with a median survival time of only 12 months.<ref>http://www.childrenshospital.org/az/Site963/mainpageS963P0.html</ref> Surgery is not practical considering the extent of the disease, standard [[chemotherapy]] (nitrosourea) has been unsuccessful, and while brain irradiation can stabilize or improve neurologic function in some patients, its impact on survival has yet to be proven.{{Fact|date=February 2007}}
+==[[Gliomatosis cerebri historical perspective|Historical Perspective]]==
+==[[Gliomatosis cerebri classification|Classification]]==
+==[[Gliomatosis cerebri pathophysiology|Pathophysiology]]==
+==[[Gliomatosis cerebri causes|Causes]]==
+==[[Gliomatosis cerebri differential diagnosis|Differentiating Gliomatosis cerebri from other Diseases]]==
+==[[Gliomatosis cerebri epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Gliomatosis cerebri risk factors|Risk Factors]]==
+==[[Gliomatosis cerebri screening|Screening]]==
+==[[Gliomatosis cerebri natural history, complications, and prognosis|Natural History, Complications, and Prognosis]]==
+==Diagnosis==
+[[Gliomatosis cerebri staging|Staging]] | [[Gliomatosis cerebri history and symptoms|History and Symptoms]] | [[Gliomatosis cerebri physical examination|Physical Examination]] | [[Gliomatosis cerebri laboratory tests|Laboratory Findings]] | [[Gliomatosis cerebri chest x ray|Chest X Ray]] | [[Gliomatosis cerebri CT|CT]] | [[Gliomatosis cerebri MRI|MRI]] | [[Gliomatosis cerebri ultrasound|Ultrasound]] | [[Gliomatosis cerebri other imaging findings|Other Imaging Findings]] | [[Gliomatosis cerebri other diagnostic studies|Other Diagnostic Studies]]
+==Treatment==
+[[Gliomatosis cerebri medical therapy|Medical Therapy]] | [[Gliomatosis cerebri surgery|Surgery]] | [[Gliomatosis cerebri primary prevention|Primary Prevention]] | [[Gliomatosis cerebri secondary prevention|Secondary Prevention]] | [[Gliomatosis cerebri cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gliomatosis cerebri future or investigational therapies|Future or Investigational Therapies]]
+==Case Studies==
+[[Gliomatosis cerebri case study one|Case#1]]
 ==References==
 {{reflist|2}}
-[[Category:Disease state]]
+{{Nervous tissue tumors}}
-[[Category:Types of cancer]]
-[[Category:Oncology]]
-{{Nervous tissue tumors}}
-{{SIB}}
-[[de:Gliomatosis cerebri]]
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+[[Category:Disease]]
+[[Category:Neurology]]
+[[Category:Types of cancer]]
+[[Category:Neurosurgery]]
+[[Category:Oncology]]
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+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Neurology]]
+[[Category:Neurosurgery]]