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==Overview==
{{SK}} salivary gland cancer; salivary gland neoplasia; salivary gland neoplasm; parotid tumor; parotid cancer; parotid neoplasia; parotid neoplasm; parotid gland tumor; parotid gland cancer; parotid gland neoplasia; parotid gland neoplasm; submandibular tumor, submandibular cancer; submandibular neoplasia; submandibular neoplasm; submandibular gland tumor; submandibular gland cancer; submandibular gland neoplasia; submandibular gland neoplasm; sublingual tumor; sublingual cancer; sublingual neoplasia; sublingual neoplasm; sublingual gland tumor; sublingual gland cancer; sublingual gland neoplasia; sublingual gland neoplasm; minor salivary gland cancer; minor salivary gland neoplasia; minor salivary gland neoplasm
'''Tumors of the salivary glands''' ('''salivary gland neoplasm''') are usually benign, but may be malignant.  The most common type of benign tumor is [[pleomorphic adenoma]], followed by [[Warthin's tumor]].  The most common malignant tumor is [[mucoepidermoid carcinoma]].  Eighty percent begin in the [[parotid gland]].<ref name="urlACS :: What Is Salivary Gland Cancer?">{{cite web |url=http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_salivary_gland_cancer_54.asp |title=ACS :: What Is Salivary Gland Cancer? |format= |work= |accessdate=}}</ref>
==[[Salivary gland tumor overview|Overview]]==


==Classification==
==[[Salivary gland tumor historical perspective|Historical Perspective]]==
[[File:Mixed Tumor of the Salivary Gland.jpg|thumb|Benign tumor of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumor with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland.]]


Salivary gland neoplasms are classified by the [[World Health Organization]] as primary or secondary, benign or malignant, and by tissue of origin.<ref>[[#refiarc|IARC]], p.&nbsp;210</ref> This system defines five broad categories of salivary gland neoplasms:<ref>[[#refiarc|IARC]], p.&nbsp;210</ref>
==[[Salivary gland tumor classification|Classification]]==
* ''malignant epithelial tumors'' (e.g. [[acinic cell carcinoma]], [[mucoepidermoid carcinoma]] and [[adenoid cystic carcinoma]], [[salivary duct carcinoma]])
* ''benign epithelial tumors'' (e.g. [[pleomorphic adenoma]], [[myoepithelioma]] and [[Warthin tumour]], [[sebaceous lymphadenoma]])
* ''soft tissue tumors'' ([[Hemangioma]])
* ''hematolymphoid tumors'' (e.g. [[Hodgkin lymphoma]])
* ''secondary tumors''.


== Differential Diagnosis ==  
==[[Salivary gland tumor pathophysiology|Pathophysiology]]==


In alphabetical order the different tumor types that must be differentiated from each other include the folloiwng: <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
==[[Salivary gland tumor causes|Causes]]==


=== Benign ===
==[[Salivary gland tumor differential diagnosis|Differentiating Salivary gland tumor from other Diseases]]==
*Lymphoepithelial lesion
*[[Monomorphic adenoma]]
*[[Pleomorphic adenoma]]
*Sebaceous tumor


=== Malignant ===
==[[Salivary gland tumor epidemiology and demographics|Epidemiology and Demographics]]==
*[[Adenocarcinoma]]
*Adenoid cystic carcinoma
*Malignant mixed tumor
*Mucoepidermoid carcinoma
*[[Squamous Cell Carcinoma]]


==Pathological Findings==
==[[Salivary gland tumor risk factors|Risk Factors]]==
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]


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==[[Salivary gland tumor screening|Screening]]==
<gallery heights="175" widths="175">
Image:Salivary gland enlargement 1.jpg|SALIVARY GLANDS: MIXED TUMOR OF PAROTID. The pre-auricular mass had enlarged to this size over a period of 5 years.(Courtesy of Dr. Charles E. Tomich, Indianapolis, IN.)
Image:Salivary gland enlargement 2.jpg|SALIVARY GLANDS: RECURRENT MIXED TUMOR. The characteristic multinodular growth of recurrent mixed tumor is obvious inthis parotid mass. (Courtesy of Dr. Lewis R. Eversole, Los Angeles, CA.)
</gallery>
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==[[Salivary gland tumor natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


==Diagnosis==
[[Salivary gland tumor staging|Staging]] | [[Salivary gland tumor history and symptoms|History and Symptoms]] | [[Salivary gland tumor physical examination|Physical Examination]] | [[Salivary gland tumor laboratory findings|Laboratory Findings]] | [[Salivary gland tumor fine-needle aspiration biopsy (FNAB)|Fine-needle Aspiration Biopsy (FNAB)]] | [[Salivary gland tumor head x ray|Head X Ray]] | [[Salivary gland tumor CT|CT]] | [[Salivary gland tumor MRI|MRI]] | [[Salivary gland tumor ultrasound|Ultrasound]] | [[Salivary gland tumor other imaging findings|Other Imaging Findings]] | [[Salivary gland tumor other diagnostic studies|Other Diagnostic Studies]]


<div align="left">
==Treatment==
<gallery heights="175" widths="175">
[[Salivary gland tumor medical therapy|Medical Therapy]] | [[Salivary gland tumor surgery|Surgery]] | [[Salivary gland tumor primary prevention|Primary Prevention]] | [[Salivary gland tumor secondary prevention|Secondary Prevention]] | [[Salivary gland tumor cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] |  [[Salivary gland tumor future or investigational therapies|Future or Investigational Therapies]]
Image:Salivary gland enlargement 3.jpg|SALIVARY GLANDS: MIXED TUMOR OF PALATE. Most mixed tumors involve only one side of the palate because there are few minor glands in the midline. In this case the tumor appears symmetrical on either side of the midline. Large intraoral tumors are susceptible to trauma-related ulceration, as illustrated here. (Courtesy of F. J.Kratochvil, Bethesda, MD.)
Image:Salivary gland enlargement 4.jpg|SALIVARY GLANDS: CANALICULAR ADENOMA. The upper lip is the site for over 70% of canalicular adenomas.
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<div align="left">
<gallery heights="175" widths="175">
Image:Salivary gland enlargement 5.jpg|SALIVARY GLANDS: MUCOEPIDERMOID CARCINOMA OF PALATE. These tumors frequently are slightly raised, fluctuant, bluish discolorations of the palatal mucosa that are clinically thought to represent mucous escapereactions.
Image:Salivary gland enlargement 6.jpg|SALIVARY GLANDS: ACINIC CELL ADENOCARCINOMA: CLINICAL PRESENTATION: A 2.0-cm raised subcutaneous nodule just anterior to the lower portion of the ear is a common clinical presentation for acinic cell adenocarcinoma. The tumor is in the superficial lobe of the left parotid gland of this 24-year-old man.
</gallery>
</div>
 
 
 
<div align="left">
<gallery heights="175" widths="175">
Image:Salivary gland enlargement 7.jpg|SALIVARY GLANDS: ACINIC CELL ADENOCARCINOMA: CLINICAL PRESENTATION. The upper lip, or any other intra oral site, is an uncommon location for acinic cell adenocarcinoma.
Image:Salivary gland enlargement 8.jpg|SALIVARY GLANDS: ADENOID CYSTIC CARCINOMA. This sublingual gland tumor slowly enlarged to produce a large, lobulated mass in the anterior floor of the mouth. The oral mucosa is intact.
</gallery>
</div>
 
 
 
<div align="left">
<gallery heights="175" widths="175">
Image:Salivary gland enlargement 9.jpg|SALIVARY GLANDS: POLYMORPHOUS LOW-GRADE ADENOCARCINOMA. This tumor presented as a well-circumscribed, slow growing mass at the junction of the hard and soft palates. Pronounced telangiectasia of the overlying mucosa is evident. (Courtesy of Dr. Richard Canaan, Ocean Springs,MS.)
Image:Salivary gland enlargement 12.jpg|SALIVARY GLANDS: NECROTIZING SIALOMETAPLASIA. Swelling, as shown in this photograph of a palatal lesion, is a frequent initial clinical presentation. Many of the swellings subsequently ulcerate. (Courtesy of Dr. Ralph Correll, LosAngeles, CA.)
</gallery>
</div>


==References==
==References==
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Latest revision as of 15:27, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]Simrat Sarai, M.D. [3]

Synonyms and keywords: salivary gland cancer; salivary gland neoplasia; salivary gland neoplasm; parotid tumor; parotid cancer; parotid neoplasia; parotid neoplasm; parotid gland tumor; parotid gland cancer; parotid gland neoplasia; parotid gland neoplasm; submandibular tumor, submandibular cancer; submandibular neoplasia; submandibular neoplasm; submandibular gland tumor; submandibular gland cancer; submandibular gland neoplasia; submandibular gland neoplasm; sublingual tumor; sublingual cancer; sublingual neoplasia; sublingual neoplasm; sublingual gland tumor; sublingual gland cancer; sublingual gland neoplasia; sublingual gland neoplasm; minor salivary gland cancer; minor salivary gland neoplasia; minor salivary gland neoplasm

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Salivary gland tumor from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Fine-needle Aspiration Biopsy (FNAB) | Head X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

References

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