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{{Infobox_gene}}
{{PBB_Controls
'''U5 small nuclear ribonucleoprotein 200 kDa helicase''' is an [[enzyme]] that in [[humans]] is encoded by the ''SNRNP200'' [[gene]].<ref name="pmid9872452">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 |date=Apr 1999 | pmid = 9872452 | pmc =  | doi =10.1093/dnares/5.5.277  }}</ref><ref name="pmid8670905">{{cite journal | vauthors = Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R | title = The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases | journal = EMBO J | volume = 15 | issue = 15 | pages = 4001–15 |date=Oct 1996 | pmid = 8670905 | pmc = 452120 | doi =  }}</ref><ref name="pmid9774689">{{cite journal | vauthors = Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R | title = The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein | journal = Mol Cell Biol | volume = 18 | issue = 11 | pages = 6756–66 |date=Nov 1998 | pmid = 9774689 | pmc = 109259 | doi 10.1128/mcb.18.11.6756}}</ref><ref name="pmid9539711">{{cite journal | vauthors = Laggerbauer B, Achsel T, Luhrmann R | title = The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 8 | pages = 4188–92 |date=May 1998 | pmid = 9539711 | pmc = 22463 | doi =10.1073/pnas.95.8.4188 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23020| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_ASCC3L1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2q0z.
| PDB = {{PDB2|2q0z}}
| Name = Activating signal cointegrator 1 complex subunit 3-like 1
| HGNCid = 30859
| Symbol = ASCC3L1
| AltSymbols =; BRR2; HELIC2; U5-200KD
| OMIM = 601664
| ECnumber =
| Homologene = 5859
| MGIid = 2444401
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005682 |text = snRNP U5}}
| Process = {{GNF_GO|id=GO:0000360 |text = cis assembly of U2-type pre-catalytic spliceosome}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23020
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_054733
    | Hs_RefseqmRNA = NM_014014
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =
    | Hs_Uniprot =
    | Mm_EntrezGene = 320632
    | Mm_Ensembl = ENSMUSG00000003660
    | Mm_RefseqmRNA = NM_177214
    | Mm_RefseqProtein = NP_796188
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 126899840
    | Mm_GenLoc_end = 126931894
    | Mm_Uniprot =   
  }}
}}
'''Activating signal cointegrator 1 complex subunit 3-like 1''', also known as '''ASCC3L1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23020| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|SNRNP200}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
*{{cite journal  | author=Laggerbauer B, Lauber J, Lührmann R |title=Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs. |journal=Nucleic Acids Res. |volume=24 |issue= 5 |pages= 868-75 |year= 1996 |pmid= 8600454 |doi= }}
*{{cite journal  | vauthors=Laggerbauer B, Lauber J, Lührmann R |title=Identification of an RNA-dependent ATPase activity in mammalian U5 snRNPs |journal=Nucleic Acids Res. |volume=24 |issue= 5 |pages= 868–75 |year= 1996 |pmid= 8600454 |doi=10.1093/nar/24.5.868 | pmc=145735 }}
*{{cite journal  | author=Lauber J, Fabrizio P, Teigelkamp S, ''et al.'' |title=The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. |journal=EMBO J. |volume=15 |issue= 15 |pages= 4001-15 |year= 1996 |pmid= 8670905 |doi=  }}
*{{cite journal  | vauthors=Meister G, Hannus S, Plöttner O |title=SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome |journal=EMBO J. |volume=20 |issue= 9 |pages= 2304–14 |year= 2001 |pmid= 11331595 |doi= 10.1093/emboj/20.9.2304 | pmc=125440 |display-authors=etal}}
*{{cite journal  | author=Laggerbauer B, Achsel T, Lührmann R |title=The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 8 |pages= 4188-92 |year= 1998 |pmid= 9539711 |doi=  }}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}}
*{{cite journal | author=Achsel T, Ahrens K, Brahms H, ''et al.'' |title=The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6756-66 |year= 1998 |pmid= 9774689 |doi=  }}
*{{cite journal  | vauthors=Jurica MS, Licklider LJ, Gygi SR |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266  |display-authors=etal}}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277-86 |year= 1999 |pmid= 9872452 |doi=  }}
*{{cite journal  | vauthors=Peng R, Dye BT, Pérez I |title=PSF and p54nrb bind a conserved stem in U5 snRNA |journal=RNA |volume=8 |issue= 10 |pages= 1334–47 |year= 2002 |pmid= 12403470 |doi=10.1017/S1355838202022070  | pmc=1370341 |display-authors=etal}}
*{{cite journal  | author=Meister G, Hannus S, Plöttner O, ''et al.'' |title=SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2304-14 |year= 2001 |pmid= 11331595 |doi= 10.1093/emboj/20.9.2304 }}
*{{cite journal  | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Peng R, Dye BT, Pérez I, ''et al.'' |title=PSF and p54nrb bind a conserved stem in U5 snRNA. |journal=RNA |volume=8 |issue= 10 |pages= 1334-47 |year= 2002 |pmid= 12403470 |doi=  }}
*{{cite journal  | vauthors=Will CL, Schneider C, Hossbach M |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=10.1261/rna.7320604  | pmc=1370585 |display-authors=etal}}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  | vauthors=Vertegaal AC, Ogg SC, Jaffray E |title=A proteomic study of SUMO-2 target proteins |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33791–8 |year= 2004 |pmid= 15175327 |doi= 10.1074/jbc.M404201200 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
*{{cite journal  | author=Will CL, Schneider C, Hossbach M, ''et al.'' |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929-41 |year= 2004 |pmid= 15146077 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Vertegaal AC, Ogg SC, Jaffray E, ''et al.'' |title=A proteomic study of SUMO-2 target proteins. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33791-8 |year= 2004 |pmid= 15175327 |doi= 10.1074/jbc.M404201200 }}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=23020}}
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{{Ribonucleoproteins}}
[[Category:Spliceosome]]


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Latest revision as of 18:19, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.[1][2][3][4][5]


References

  1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  2. Lauber J, Fabrizio P, Teigelkamp S, Lane WS, Hartmann E, Luhrmann R (Oct 1996). "The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases". EMBO J. 15 (15): 4001–15. PMC 452120. PMID 8670905.
  3. Achsel T, Ahrens K, Brahms H, Teigelkamp S, Luhrmann R (Nov 1998). "The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein". Mol Cell Biol. 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.
  4. Laggerbauer B, Achsel T, Luhrmann R (May 1998). "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro". Proc Natl Acad Sci U S A. 95 (8): 4188–92. doi:10.1073/pnas.95.8.4188. PMC 22463. PMID 9539711.
  5. "Entrez Gene: ASCC3L1 activating signal cointegrator 1 complex subunit 3-like 1".

External links

Further reading