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'''Centromere protein C 1''' is a [[protein]] that in humans is encoded by the ''CENPC1'' [[gene]].<ref name="pmid7959789">{{cite journal | vauthors = McKay S, Thomson E, Cooke H | title = Sequence homologies and linkage group conservation of the human and mouse Cenpc genes | journal = Genomics | volume = 22 | issue = 1 | pages = 36–40 |date=Dec 1994 | pmid = 7959789 | pmc = | doi = 10.1006/geno.1994.1342 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPC1 centromere protein C 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1060| accessdate = }}</ref> | |||
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| summary_text = Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.<ref name="entrez" | | summary_text = Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CENPC}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Saitoh H, Tomkiel J, Cooke CA |title=CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. |journal=Cell |volume=70 |issue= 1 |pages= 115–25 |year= 1992 |pmid= 1339310 |doi=10.1016/0092-8674(92)90538-N |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767–74 |year= 1996 |pmid= 8702533 |doi=10.1074/jbc.271.31.18767 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Xie Y, Heng HH |title=FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 3 |pages= 192–3 |year= 1996 |pmid= 8941372 |doi=10.1159/000134412 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Xie Y, Ni ZM, Gu JR |title=Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore. |journal=Cell Res. |volume=7 |issue= 1 |pages= 13–9 |year= 1997 |pmid= 9261558 |doi= 10.1038/cr.1997.2|display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Pluta AF, Earnshaw WC, Goldberg IG |title=Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. | series=111 |journal=J. Cell Sci. |volume=( Pt 14) |issue= |pages= 2029–41 |year= 1998 |pmid= 9645950 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Song K, Gronemeyer B, Lu W |title=Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C). |journal=Exp. Cell Res. |volume=275 |issue= 1 |pages= 81–91 |year= 2002 |pmid= 11925107 |doi= 10.1006/excr.2002.5495 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Politi V, Perini G, Trazzi S |title=CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. |journal=J. Cell Sci. |volume=115 |issue= Pt 11 |pages= 2317–27 |year= 2002 |pmid= 12006616 |doi= |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Trazzi S, Bernardoni R, Diolaiti D |title=In vivo functional dissection of human inner kinetochore protein CENP-C. |journal=J. Struct. Biol. |volume=140 |issue= 1-3 |pages= 39–48 |year= 2003 |pmid= 12490152 |doi=10.1016/S1047-8477(02)00506-3 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Suzuki N, Nakano M, Nozaki N |title=CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5934–46 |year= 2004 |pmid= 14612452 |doi= 10.1074/jbc.M306477200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Obuse C, Yang H, Nozaki N |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Chung TL, Hsiao HH, Yeh YY |title=In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39653–62 |year= 2004 |pmid= 15272016 |doi= 10.1074/jbc.M405637200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Foltz DR, Jansen LE, Black BE |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458–69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Izuta H, Ikeno M, Suzuki N |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673–84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x |display-authors=etal}} | ||
*{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Faragher AJ, Sun XM, Butterworth M |title=Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1337–47 |year= 2007 |pmid= 17287400 |doi= 10.1091/mbc.E06-05-0409 | pmc=1838999 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Wong LH, Brettingham-Moore KH, Chan L |title=Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere. |journal=Genome Res. |volume=17 |issue= 8 |pages= 1146–60 |year= 2007 |pmid= 17623812 |doi= 10.1101/gr.6022807 | pmc=1933521 |display-authors=etal}} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{Chromosome genetics}} | {{Chromosome genetics}} | ||
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Latest revision as of 19:32, 8 November 2017
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Species | Human | Mouse | |||||
Entrez |
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UniProt |
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Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.[1][2]
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.[2]
References
- ↑ McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.
- ↑ 2.0 2.1 "Entrez Gene: CENPC1 centromere protein C 1".
External links
- Human CENPC genome location and CENPC gene details page in the UCSC Genome Browser.
Further reading
- Saitoh H, Tomkiel J, Cooke CA, et al. (1992). "CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate". Cell. 70 (1): 115–25. doi:10.1016/0092-8674(92)90538-N. PMID 1339310.
- Pluta AF, Earnshaw WC (1996). "Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator". J. Biol. Chem. 271 (31): 18767–74. doi:10.1074/jbc.271.31.18767. PMID 8702533.
- Xie Y, Heng HH (1996). "FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21". Cytogenet. Cell Genet. 74 (3): 192–3. doi:10.1159/000134412. PMID 8941372.
- Xie Y, Ni ZM, Gu JR, et al. (1997). "Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore". Cell Res. 7 (1): 13–9. doi:10.1038/cr.1997.2. PMID 9261558.
- Pluta AF, Earnshaw WC, Goldberg IG (1998). "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death". J. Cell Sci. 111. ( Pt 14): 2029–41. PMID 9645950.
- Song K, Gronemeyer B, Lu W, et al. (2002). "Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C)". Exp. Cell Res. 275 (1): 81–91. doi:10.1006/excr.2002.5495. PMID 11925107.
- Politi V, Perini G, Trazzi S, et al. (2002). "CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains". J. Cell Sci. 115 (Pt 11): 2317–27. PMID 12006616.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Trazzi S, Bernardoni R, Diolaiti D, et al. (2003). "In vivo functional dissection of human inner kinetochore protein CENP-C". J. Struct. Biol. 140 (1–3): 39–48. doi:10.1016/S1047-8477(02)00506-3. PMID 12490152.
- Rodriguez M, Yu X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
- Suzuki N, Nakano M, Nozaki N, et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization". J. Biol. Chem. 279 (7): 5934–46. doi:10.1074/jbc.M306477200. PMID 14612452.
- Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
- Chung TL, Hsiao HH, Yeh YY, et al. (2004). "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides". J. Biol. Chem. 279 (38): 39653–62. doi:10.1074/jbc.M405637200. PMID 15272016.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
- Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Faragher AJ, Sun XM, Butterworth M, et al. (2007). "Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase". Mol. Biol. Cell. 18 (4): 1337–47. doi:10.1091/mbc.E06-05-0409. PMC 1838999. PMID 17287400.
- Wong LH, Brettingham-Moore KH, Chan L, et al. (2007). "Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere". Genome Res. 17 (8): 1146–60. doi:10.1101/gr.6022807. PMC 1933521. PMID 17623812.
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