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{{Infobox_gene}}
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'''F-box/LRR-repeat protein 5''' is a [[protein]] that in humans is encoded by the ''FBXL5'' [[gene]].<ref name="pmid10531035">{{cite journal | vauthors = Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M | title = Identification of a family of human F-box proteins | journal = Curr Biol | volume = 9 | issue = 20 | pages = 1177–9 |date=Dec 1999 | pmid = 10531035 | pmc =  | doi = 10.1016/S0960-9822(00)80020-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26234| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = F-box and leucine-rich repeat protein 5
| HGNCid = 13602
| Symbol = FBXL5
| AltSymbols =; FBL4; FBL5; FLR1
| OMIM = 605655
| ECnumber =
| Homologene = 8129
| MGIid = 2152883
  | GeneAtlas_image1 = PBB_GE_FBXL5_209004_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FBXL5_209005_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}}
| Process = {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26234
    | Hs_Ensembl = ENSG00000118564
    | Hs_RefseqProtein = NP_036293
    | Hs_RefseqmRNA = NM_012161
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 15215252
    | Hs_GenLoc_end = 15266111
    | Hs_Uniprot = Q9UKA1
    | Mm_EntrezGene = 242960
    | Mm_Ensembl = ENSMUSG00000039753
    | Mm_RefseqmRNA = NM_178729
    | Mm_RefseqProtein = NP_848844
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 44032866
    | Mm_GenLoc_end = 44070369
    | Mm_Uniprot = Q3TBA5
  }}
}}
'''F-box and leucine-rich repeat protein 5''', also known as '''FBXL5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26234| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26234| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[F-box protein]] family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.<ref name="entrez" />
}}
}}
FBXL5 is an iron sensor. It promotes [[Iron-responsive element-binding protein|IRP2]] ubiquitination and then its degradation.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G  }}
*{{cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, ''et al.'' |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177-9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2 }}
*{{cite journal  | author=Winston JT |title=A family of mammalian F-box proteins |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 |name-list-format=vanc| author2=Koepp DM  | author3=Zhu C  | display-authors=3  | last4=Elledge  | first4=Stephen J.  | last5=Harper  | first5=J.Wade }}
*{{cite journal  | author=Winston JT, Koepp DM, Zhu C, ''et al.'' |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180-2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 }}
*{{cite journal  | vauthors=Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C |title=cDNA cloning and expression analysis of new members of the mammalian F-box protein family |journal=Genomics |volume=67 |issue= 1 |pages= 40–7 |year= 2001 |pmid= 10945468 |doi= 10.1006/geno.2000.6211 }}
*{{cite journal  | author=Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C |title=cDNA cloning and expression analysis of new members of the mammalian F-box protein family. |journal=Genomics |volume=67 |issue= 1 |pages= 40-7 |year= 2001 |pmid= 10945468 |doi= 10.1006/geno.2000.6211 }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072  |name-list-format=vanc| author2=Weil B  | author3=Wellenreuther R  | display-authors=3  | last4=Gassenhuber  | first4=J  | last5=Glassl  | first5=S  | last6=Ansorge  | first6=W  | last7=Böcher  | first7=M  | last8=Blöcker  | first8=H  | last9=Bauersachs  | first9=S }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Zhang N |title=FBXL5 interacts with p150Glued and regulates its ubiquitination |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 1 |pages= 34–9 |year= 2007 |pmid= 17532294 |doi= 10.1016/j.bbrc.2007.05.068 |name-list-format=vanc| author2=Liu J  | author3=Ding X  | display-authors=3  | last4=Aikhionbare  | first4=Felix  | last5=Jin  | first5=Changjiang  | last6=Yao  | first6=Xuebiao }}
*{{cite journal  | author=Zhang N, Liu J, Ding X, ''et al.'' |title=FBXL5 interacts with p150Glued and regulates its ubiquitination. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 1 |pages= 34-9 |year= 2007 |pmid= 17532294 |doi= 10.1016/j.bbrc.2007.05.068 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 04:40, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

F-box/LRR-repeat protein 5 is a protein that in humans is encoded by the FBXL5 gene.[1][2]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.[2]

FBXL5 is an iron sensor. It promotes IRP2 ubiquitination and then its degradation.

References

  1. ↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  2. ↑ 2.0 2.1 "Entrez Gene: FBXL5 F-box and leucine-rich repeat protein 5".

Further reading



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