GNG3: Difference between revisions

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{{Infobox_gene}}
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'''Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3''' is a [[protein]] that in humans is encoded by the ''GNG3'' [[gene]].<ref name="pmid10644457">{{cite journal |vauthors=Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 |date=Mar 2000 | pmid = 10644457 | pmc =  | doi = 10.1006/geno.1999.5992 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2785| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Guanine nucleotide binding protein (G protein), gamma 3
| HGNCid = 4405
| Symbol = GNG3
| AltSymbols =;
| OMIM = 608941
| ECnumber = 
| Homologene = 22575
| MGIid = 102704
| GeneAtlas_image1 = PBB_GE_GNG3_222005_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2785
    | Hs_Ensembl = ENSG00000162188
    | Hs_RefseqProtein = NP_036334
    | Hs_RefseqmRNA = NM_012202
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 62231706
    | Hs_GenLoc_end = 62233251
    | Hs_Uniprot = P63215
    | Mm_EntrezGene = 14704
    | Mm_Ensembl = ENSMUSG00000071658
    | Mm_RefseqmRNA = NM_010316
    | Mm_RefseqProtein = NP_034446
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 8903974
    | Mm_GenLoc_end = 8906291
    | Mm_Uniprot = P63216
  }}
}}
'''Guanine nucleotide binding protein (G protein), gamma 3''', also known as '''GNG3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2785| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2785| accessdate = }}</ref>
| summary_text = G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wedegaertner PB, Wilson PT, Bourne HR |title=Lipid modifications of trimeric G proteins. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 503-6 |year= 1995 |pmid= 7822269 |doi=  }}
*{{cite journal  |vauthors=Wedegaertner PB, Wilson PT, Bourne HR |title=Lipid modifications of trimeric G proteins. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 503–6 |year= 1995 |pmid= 7822269 |doi=10.1074/jbc.270.2.503  }}
*{{cite journal  | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544-52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
*{{cite journal  |vauthors=Garcia-Higuera I, Thomas TC, Yi F, Neer EJ |title=Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 528–35 |year= 1996 |pmid= 8550614 |doi=  10.1074/jbc.271.1.528}}
*{{cite journal  | author=Garcia-Higuera I, Thomas TC, Yi F, Neer EJ |title=Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 528-35 |year= 1996 |pmid= 8550614 |doi=  }}
*{{cite journal  |vauthors=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=10.1074/jbc.271.12.7141 }}
*{{cite journal  | author=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141-6 |year= 1996 |pmid= 8636150 |doi=  }}
*{{cite journal  |vauthors=Morishita R, Saga S, Kawamura N |title=Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. |journal=J. Neurochem. |volume=68 |issue= 2 |pages= 820–7 |year= 1997 |pmid= 9003074 |doi=10.1046/j.1471-4159.1997.68020820.x |display-authors=etal}}
*{{cite journal  | author=Morishita R, Saga S, Kawamura N, ''et al.'' |title=Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. |journal=J. Neurochem. |volume=68 |issue= 2 |pages= 820-7 |year= 1997 |pmid= 9003074 |doi=  }}
*{{cite journal  |vauthors=Bell B, Xing H, Yan K |title=KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7982–6 |year= 1999 |pmid= 10075696 |doi=10.1074/jbc.274.12.7982 |display-authors=etal}}
*{{cite journal  | author=Bell B, Xing H, Yan K, ''et al.'' |title=KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7982-6 |year= 1999 |pmid= 10075696 |doi=  }}
*{{cite journal  |vauthors=Hurowitz EH, Melnyk JM, Chen YJ |title=Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. |journal=DNA Res. |volume=7 |issue= 2 |pages= 111–20 |year= 2000 |pmid= 10819326 |doi=10.1093/dnares/7.2.111 |display-authors=etal}}
*{{cite journal  | author=Hurowitz EH, Melnyk JM, Chen YJ, ''et al.'' |title=Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. |journal=DNA Res. |volume=7 |issue= 2 |pages= 111-20 |year= 2000 |pmid= 10819326 |doi=  }}
*{{cite journal  |vauthors=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945–53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200 }}
*{{cite journal  | author=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945-53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Cuello F, Schulze RA, Heemeyer F |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 |display-authors=etal}}
*{{cite journal  | author=Cuello F, Schulze RA, Heemeyer F, ''et al.'' |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220-6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 }}
*{{cite journal  |vauthors=Kato C, Mizutani T, Tamaki H |title=Characterization of heterotrimeric G protein complexes in rice plasma membrane |journal=Plant J. |volume=38 |issue= 2 |pages= 320–31 |year= 2004 |pmid= 15078334 |doi= 10.1111/j.1365-313X.2004.02046.x |display-authors=etal}}
*{{cite journal  | author=Kato C, Mizutani T, Tamaki H, ''et al.'' |title=Characterization of heterotrimeric G protein complexes in rice plasma membrane. |journal=Plant J. |volume=38 |issue= 2 |pages= 320-31 |year= 2004 |pmid= 15078334 |doi= 10.1111/j.1365-313X.2004.02046.x }}
*{{cite journal  |vauthors=Schwindinger WF, Giger KE, Betz KS |title=Mice with Deficiency of G Protein γ3 Are Lean and Have Seizures |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7758–68 |year= 2004 |pmid= 15314181 |doi= 10.1128/MCB.24.17.7758-7768.2004 | pmc=506985 |display-authors=etal}}
*{{cite journal  | author=Schwindinger WF, Giger KE, Betz KS, ''et al.'' |title=Mice with deficiency of G protein gamma3 are lean and have seizures. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7758-68 |year= 2004 |pmid= 15314181 |doi= 10.1128/MCB.24.17.7758-7768.2004 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


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{{Intracellular signaling peptides and proteins}}
 
 
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Latest revision as of 08:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.[1][2]

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM][2]

References

  1. ↑ Downes GB, Gautam N (Mar 2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
  2. ↑ 2.0 2.1 "Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3".

Further reading



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