OR2D2: Difference between revisions

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{{Infobox_gene}}
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'''Olfactory receptor 2D2''' is a [[protein]] that in humans is encoded by the ''OR2D2'' [[gene]].<ref name="pmid9787077">{{cite journal |vauthors=Buettner JA, Glusman G, Ben-Arie N, Ramos P, Lancet D, Evans GA | title = Organization and evolution of olfactory receptor genes on human chromosome 11 | journal = Genomics | volume = 53 | issue = 1 | pages = 56–68 |date=Dec 1998 | pmid = 9787077 | pmc =  | doi = 10.1006/geno.1998.5422 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR2D2 olfactory receptor, family 2, subfamily D, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=120776| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 2, subfamily D, member 2
| HGNCid = 8244
| Symbol = OR2D2
| AltSymbols =; OR11-610; OR2D1; hg27
| OMIM = 608494
| ECnumber = 
| Homologene = 81541
| MGIid = 3030549
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 120776
    | Hs_Ensembl = ENSG00000166368
    | Hs_RefseqProtein = NP_003691
    | Hs_RefseqmRNA = NM_003700
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 6869381
    | Hs_GenLoc_end = 6870307
    | Hs_Uniprot = Q9H210
    | Mm_EntrezGene = 258776
    | Mm_Ensembl = ENSMUSG00000062987
    | Mm_RefseqmRNA = NM_146780
    | Mm_RefseqProtein = NP_666991
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 106919621
    | Mm_GenLoc_end = 106920568
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 2, subfamily D, member 2''', also known as '''OR2D2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2D2 olfactory receptor, family 2, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=120776| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2D2 olfactory receptor, family 2, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=120776| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
}}
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Buettner JA, Glusman G, Ben-Arie N, ''et al.'' |title=Organization and evolution of olfactory receptor genes on human chromosome 11. |journal=Genomics |volume=53 |issue= 1 |pages= 56-68 |year= 1998 |pmid= 9787077 |doi= 10.1006/geno.1998.5422 }}
*{{cite journal  | author=Fuchs T |title=DEFOG: a practical scheme for deciphering families of genes |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 |name-list-format=vanc| author2=Malecova B | author3=Linhart C | display-authors=3  | last4=Sharan  | first4=Roded  | last5=Khen  | first5=Miriam  | last6=Herwig  | first6=Ralf  | last7=Shmulevich  | first7=Dmitry  | last8=Elkon  | first8=Rani  | last9=Steinfath  | first9=Matthias }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
*{{cite journal  |vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]

Latest revision as of 02:38, 27 October 2017

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SpeciesHumanMouse
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View/Edit Human

Olfactory receptor 2D2 is a protein that in humans is encoded by the OR2D2 gene.[1][2]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[2]

See also

References

  1. ↑ Buettner JA, Glusman G, Ben-Arie N, Ramos P, Lancet D, Evans GA (Dec 1998). "Organization and evolution of olfactory receptor genes on human chromosome 11". Genomics. 53 (1): 56–68. doi:10.1006/geno.1998.5422. PMID 9787077.
  2. ↑ 2.0 2.1 "Entrez Gene: OR2D2 olfactory receptor, family 2, subfamily D, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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