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{{Infobox_gene}}
{{PBB_Controls
'''Olfactory receptor 51M1''' is a [[protein]] that in humans is encoded by the ''OR51M1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=390059| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 51, subfamily M, member 1
| HGNCid = 14847
| Symbol = OR51M1
| AltSymbols =; HOR5'Beta7; OR11-40
| OMIM = 
| ECnumber = 
| Homologene = 64935
| MGIid = 3030465
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 390059
    | Hs_Ensembl = ENSG00000184698
    | Hs_RefseqProtein = NP_001004756
    | Hs_RefseqmRNA = NM_001004756
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 5367205
    | Hs_GenLoc_end = 5368185
    | Hs_Uniprot = Q9H341
    | Mm_EntrezGene = 258961
    | Mm_Ensembl = ENSMUSG00000042219
    | Mm_RefseqmRNA = XM_993393
    | Mm_RefseqProtein = XP_998487
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 103788883
    | Mm_GenLoc_end = 103803732
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 51, subfamily M, member 1''', also known as '''OR51M1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=390059| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Olfactory receptors interact with [[odorant]] molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The [[olfactory receptor]] proteins are members of a large family of [[G-protein-coupled receptor]]s (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.<ref name=Knape>{{cite journal | vauthors = Knape K, Beyer A, Stary A, Buchbauer G, Wolschann P | title = Genomics of selected human odorant receptors | journal = Chemical Monthly | year = 2008 | volume = 139 | issue = 12 | pages = 1537–1544 | doi = 10.1007/s00706-008-0957-6 }}</ref> The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=390059| accessdate = }}</ref>
}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Bulger M, van Doorninck JH, Saitoh N, etal |title=Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 5129–34 |year= 1999 |pmid= 10220430 |doi=10.1073/pnas.96.9.5129  | pmc=21828 }}
| citations =
*{{cite journal   |vauthors=Bulger M, Bender MA, van Doorninck JH, etal |title=Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14560–5 |year= 2001 |pmid= 11121057 |doi= 10.1073/pnas.97.26.14560 | pmc=18958 }}
*{{cite journal | author=Bulger M, van Doorninck JH, Saitoh N, ''et al.'' |title=Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 9 |pages= 5129-34 |year= 1999 |pmid= 10220430 |doi=  }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal | author=Bulger M, Bender MA, van Doorninck JH, ''et al.'' |title=Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14560-5 |year= 2001 |pmid= 11121057 |doi= 10.1073/pnas.97.26.14560 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
}}
{{refend}}
{{refend}}


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{{Olfactory receptors}}
{{Olfactory receptors}}
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{{transmembranereceptor-stub}}

Latest revision as of 02:52, 27 October 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Olfactory receptor 51M1 is a protein that in humans is encoded by the OR51M1 gene.[1]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.[2] The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: OR51M1 olfactory receptor, family 51, subfamily M, member 1".
  2. ↑ Knape K, Beyer A, Stary A, Buchbauer G, Wolschann P (2008). "Genomics of selected human odorant receptors". Chemical Monthly. 139 (12): 1537–1544. doi:10.1007/s00706-008-0957-6.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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