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{{Infobox_gene}}
{{PBB_Controls
'''E3 SUMO-protein ligase PIAS1''' is an [[enzyme]] that in humans is encoded by the ''PIAS1'' [[gene]].<ref name="pmid9724754">{{cite journal | vauthors = Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K | title = Inhibition of Stat1-mediated gene activation by PIAS1 | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 18 | pages = 10626–10631 | date = September 1998 | pmid = 9724754 | pmc = 27945 | doi = 10.1073/pnas.95.18.10626 }}</ref><ref name="pmid9177271">{{cite journal | vauthors = Valdez BC, Henning D, Perlaky L, Busch RK, Busch H | title = Cloning and characterization of Gu/RH-II binding protein | journal = Biochem Biophys Res Commun | volume = 234 | issue = 2 | pages = 335–340 | date = July 1997 | pmid = 9177271 | pmc = | doi = 10.1006/bbrc.1997.6642 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PIAS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1v66.
| PDB = {{PDB2|1v66}}
| Name = Protein inhibitor of activated STAT, 1
| HGNCid = 2752
| Symbol = PIAS1
| AltSymbols =; GBP; DDXBP1; GU/RH-II; MGC141878; MGC141879; ZMIZ3
| OMIM = 603566
| ECnumber = 
| Homologene = 22953
| MGIid = 1913125
| GeneAtlas_image1 = PBB_GE_PIAS1_217864_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004004 |text = ATP-dependent RNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8554
    | Hs_Ensembl = ENSG00000033800
    | Hs_RefseqProtein = NP_057250
    | Hs_RefseqmRNA = NM_016166
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 66165695
    | Hs_GenLoc_end = 66267392
    | Hs_Uniprot = O75925
    | Mm_EntrezGene = 56469
    | Mm_Ensembl = ENSMUSG00000032405
    | Mm_RefseqmRNA = NM_019663
    | Mm_RefseqProtein = NP_062637
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 62679132
    | Mm_GenLoc_end = 62778885
    | Mm_Uniprot = Q2M4G9
  }}
}}
'''Protein inhibitor of activated STAT, 1''', also known as '''PIAS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8554| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PIAS1 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
* [[DNMT3A]],<ref name = pmid14752048>{{cite journal | vauthors = Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD | title = Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription | journal = Nucleic Acids Res. | volume = 32 | issue = 2 | pages = 598–610 | pmid = 14752048 | pmc = 373322 | doi = 10.1093/nar/gkh195 }}</ref>
{{PBB_Further_reading
* [[P53]],<ref name = pmid11583632/><ref name = pmid10380882>{{cite journal | vauthors = Gallagher WM, Argentini M, Sierra V, Bracco L, Debussche L, Conseiller E | title = MBP1: a novel mutant p53-specific protein partner with oncogenic properties | journal = Oncogene | volume = 18 | issue = 24 | pages = 3608–16 | date = June 1999 | pmid = 10380882 | doi = 10.1038/sj.onc.1202937 }}</ref>
| citations =
* [[STAT1]],<ref name = pmid10805787>{{cite journal | vauthors = Liao J, Fu Y, Shuai K | title = Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 10 | pages = 5267–72 | date = May 2000 | pmid = 10805787 | pmc = 25817 | doi =  10.1073/pnas.97.10.5267}}</ref>
*{{cite journal  | author=Valdez BC, Henning D, Perlaky L, ''et al.'' |title=Cloning and characterization of Gu/RH-II binding protein. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 2 |pages= 335-40 |year= 1997 |pmid= 9177271 |doi= 10.1006/bbrc.1997.6642 }}
* [[Small ubiquitin-related modifier 1]],<ref name = pmid11583632>{{cite journal | vauthors = Kahyo T, Nishida T, Yasuda H | title = Involvement of PIAS1 in the sumoylation of tumor suppressor p53 | journal = Mol. Cell | volume = 8 | issue = 3 | pages = 713–8 | date = September 2001 | pmid = 11583632 | doi =  10.1016/s1097-2765(01)00349-5}}</ref><ref name = pmid14609633>{{cite journal | vauthors = Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J | title = Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules | journal = Virus Res. | volume = 98 | issue = 1 | pages = 83–91 | date = December 2003 | pmid = 14609633 | doi =  10.1016/j.virusres.2003.09.001}}</ref>
*{{cite journal | author=Liu B, Liao J, Rao X, ''et al.'' |title=Inhibition of Stat1-mediated gene activation by PIAS1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10626-31 |year= 1998 |pmid= 9724754 |doi= }}
* [[Sp3 transcription factor]],<ref name = pmid12356736>{{cite journal | vauthors = Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G | title = Transcription factor Sp3 is silenced through SUMO modification by PIAS1 | journal = EMBO J. | volume = 21 | issue = 19 | pages = 5206–15 | date = October 2002 | pmid = 12356736 | pmc = 129032 | doi = 10.1093/emboj/cdf510}}</ref>  and
*{{cite journal | author=Tan J, Hall SH, Hamil KG, ''et al.'' |title=Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. |journal=Mol. Endocrinol. |volume=14 |issue= 1 |pages= 14-26 |year= 2000 |pmid= 10628744 |doi=  }}
* [[UBE2I]].<ref name = pmid11583632/><ref name = pmid14609633/><ref name = pmid12356736/>
*{{cite journal | author=Liao J, Fu Y, Shuai K |title=Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 10 |pages= 5267-72 |year= 2000 |pmid= 10805787 |doi=  }}
 
*{{cite journal | author=Kotaja N, Aittomäki S, Silvennoinen O, ''et al.'' |title=ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. |journal=Mol. Endocrinol. |volume=14 |issue= 12 |pages= 1986-2000 |year= 2001 |pmid= 11117529 |doi=  }}
== References ==
*{{cite journal | author=Gross M, Liu B, Tan  J, ''et al.'' |title=Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells. |journal=Oncogene |volume=20 |issue= 29 |pages= 3880-7 |year= 2001 |pmid= 11439351 |doi= 10.1038/sj.onc.1204489 }}
{{reflist}}
*{{cite journal | author=Liu B, Shuai K |title=Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36624-31 |year= 2001 |pmid= 11451946 |doi= 10.1074/jbc.M101085200 }}
{{Clear}}
*{{cite journal | author=Kahyo T, Nishida T, Yasuda H |title=Involvement of PIAS1 in the sumoylation of tumor suppressor p53. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 713-8 |year= 2001 |pmid= 11583632 |doi= }}
 
*{{cite journal | author=Weiskirchen R, Moser M, Weiskirchen S, ''et al.'' |title=LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. |journal=Biochem. J. |volume=359 |issue= Pt 3 |pages= 485-96 |year= 2001 |pmid= 11672422 |doi= }}
== Further reading ==
*{{cite journal | author=Megidish T, Xu JH, Xu CW |title=Activation of p53 by protein inhibitor of activated Stat1 (PIAS1). |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8255-9 |year= 2002 |pmid= 11788578 |doi= 10.1074/jbc.C200001200 }}
{{refbegin|35em}}
*{{cite journal | author=Schmidt D, Müller S |title=Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2872-7 |year= 2002 |pmid= 11867732 |doi= 10.1073/pnas.052559499 }}
* {{cite journal | vauthors = Tan J, Hall SH, Hamil KG, Grossman G, Petrusz P, Liao J, Shuai K, French FS | title = Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis | journal = Mol. Endocrinol. | volume = 14 | issue = 1 | pages = 14–26 | year = 2000 | pmid = 10628744 | doi = 10.1210/me.14.1.14 }}
*{{cite journal | author=Tan JA, Hall SH, Hamil KG, ''et al.'' |title=Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16993-7001 |year= 2002 |pmid= 11877418 |doi= 10.1074/jbc.M109217200 }}
* {{cite journal | vauthors = Liao J, Fu Y, Shuai K | title = Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 10 | pages = 5267–5272 | year = 2000 | pmid = 10805787 | pmc = 25817 | doi = 10.1073/pnas.97.10.5267 }}
*{{cite journal | author=Nishida T, Yasuda H |title=PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 41311-7 |year= 2003 |pmid= 12177000 |doi= 10.1074/jbc.M206741200 }}
* {{cite journal | vauthors = Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA | title = ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation | journal = Mol. Endocrinol. | volume = 14 | issue = 12 | pages = 1986–2000 | year = 2001 | pmid = 11117529 | doi = 10.1210/mend.14.12.0569 }}
*{{cite journal | author=Rui HL, Fan E, Zhou HM, ''et al.'' |title=SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42981-6 |year= 2003 |pmid= 12223491 |doi= 10.1074/jbc.M208099200 }}
* {{cite journal | vauthors = Gross M, Liu B, Tan J, French FS, Carey M, Shuai K | title = Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells | journal = Oncogene | volume = 20 | issue = 29 | pages = 3880–3887 | year = 2001 | pmid = 11439351 | doi = 10.1038/sj.onc.1204489 }}
*{{cite journal | author=Sapetschnig A, Rischitor G, Braun H, ''et al.'' |title=Transcription factor Sp3 is silenced through SUMO modification by PIAS1. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5206-15 |year= 2002 |pmid= 12356736 |doi= }}
* {{cite journal | vauthors = Liu B, Shuai K | title = Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36624–36631 | year = 2001 | pmid = 11451946 | doi = 10.1074/jbc.M101085200 }}
*{{cite journal | author=Miyauchi Y, Yogosawa S, Honda R, ''et al.'' |title=Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50131-6 |year= 2003 |pmid= 12393906 |doi= 10.1074/jbc.M208319200 }}
* {{cite journal | vauthors = Kahyo T, Nishida T, Yasuda H | title = Involvement of PIAS1 in the sumoylation of tumor suppressor p53 | journal = Mol. Cell | volume = 8 | issue = 3 | pages = 713–718 | year = 2001 | pmid = 11583632 | doi = 10.1016/S1097-2765(01)00349-5 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM | title = LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1 | journal = Biochem. J. | volume = 359 | issue = Pt 3 | pages = 485–96 | year = 2001 | pmid = 11672422 | pmc = 1222169 | doi = 10.1042/0264-6021:3590485 }}
*{{cite journal | author=Ungureanu D, Vanhatupa S, Kotaja N, ''et al.'' |title=PIAS proteins promote SUMO-1 conjugation to STAT1. |journal=Blood |volume=102 |issue= 9 |pages= 3311-3 |year= 2004 |pmid= 12855578 |doi= 10.1182/blood-2002-12-3816 }}
* {{cite journal | vauthors = Megidish T, Xu JH, Xu CW | title = Activation of p53 by protein inhibitor of activated Stat1 (PIAS1) | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8255–8259 | year = 2002 | pmid = 11788578 | doi = 10.1074/jbc.C200001200 }}
*{{cite journal | author=Kadaré G, Toutant M, Formstecher E, ''et al.'' |title=PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47434-40 |year= 2004 |pmid= 14500712 |doi= 10.1074/jbc.M308562200 }}
* {{cite journal | vauthors = Schmidt D, Müller S | title = Members of the PIAS family act as SUMO ligases for c-Jun  and p53 and repress p53 activity | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2872–2877 | year = 2002 | pmid = 11867732 | pmc = 122440 | doi = 10.1073/pnas.052559499 }}
*{{cite journal | author=Tallec LP, Kirsh O, Lecomte MC, ''et al.'' |title=Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification. |journal=Mol. Endocrinol. |volume=17 |issue= 12 |pages= 2529-42 |year= 2004 |pmid= 14500761 |doi= 10.1210/me.2003-0299 }}
* {{cite journal | vauthors = Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS | title = Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators | journal = J. Biol. Chem. | volume = 277 | issue = 19 | pages = 16993–17001 | year = 2002 | pmid = 11877418 | doi = 10.1074/jbc.M109217200 }}
}}
* {{cite journal | vauthors = Nishida T, Yasuda H | title = PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription | journal = J. Biol. Chem. | volume = 277 | issue = 44 | pages = 41311–41317 | year = 2003 | pmid = 12177000 | doi = 10.1074/jbc.M206741200 }}
* {{cite journal | vauthors = Rui HL, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC | title = SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 42981–42986 | year = 2003 | pmid = 12223491 | doi = 10.1074/jbc.M208099200 }}
* {{cite journal | vauthors = Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G | title = Transcription factor Sp3 is silenced through SUMO modification by PIAS1 | journal = EMBO J. | volume = 21 | issue = 19 | pages = 5206–5215 | year = 2002 | pmid = 12356736 | pmc = 129032 | doi = 10.1093/emboj/cdf510 }}
* {{cite journal | vauthors = Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H | title = Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 50131–50136 | year = 2003 | pmid = 12393906 | doi = 10.1074/jbc.M208319200 }}
* {{cite journal | vauthors = Ungureanu D, Vanhatupa S, Kotaja N, Yang J, Aittomaki S, Jänne OA, Palvimo JJ, Silvennoinen O | title = PIAS proteins promote SUMO-1 conjugation to STAT1 | journal = Blood | volume = 102 | issue = 9 | pages = 3311–3313 | year = 2004 | pmid = 12855578 | doi = 10.1182/blood-2002-12-3816 }}
* {{cite journal | vauthors = Kadaré G, Toutant M, Formstecher E, Corvol JC, Carnaud M, Boutterin MC, Girault JA | title = PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation | journal = J. Biol. Chem. | volume = 278 | issue = 48 | pages = 47434–47440 | year = 2004 | pmid = 14500712 | doi = 10.1074/jbc.M308562200 }}
* {{cite journal | vauthors = Tallec LP, Kirsh O, Lecomte MC, Viengchareun S, Zennaro MC, Dejean A, Lombès M | title = Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification | journal = Mol. Endocrinol. | volume = 17 | issue = 12 | pages = 2529–2542 | year = 2004 | pmid = 14500761 | doi = 10.1210/me.2003-0299 }}
* {{cite journal | vauthors = Coppola D, Parikh V, Boulware D, Blanck G | title = Substantially reduced expression of PIAS1 is associated with colon cancer development | journal = J Cancer Res Clin Oncol. | volume = 135 | issue = 9 | pages = 1287-91  | year = 2009 | pmid = 19288270 | doi = 10.1007/s00432-009-0570-z }}
{{refend}}
{{refend}}


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Latest revision as of 18:06, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.[1][2][3]

Function

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.[3]

Interactions

PIAS1 has been shown to interact with:

References

  1. ↑ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–10631. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.
  2. ↑ Valdez BC, Henning D, Perlaky L, Busch RK, Busch H (July 1997). "Cloning and characterization of Gu/RH-II binding protein". Biochem Biophys Res Commun. 234 (2): 335–340. doi:10.1006/bbrc.1997.6642. PMID 9177271.
  3. ↑ 3.0 3.1 "Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1".
  4. ↑ Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD. "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription". Nucleic Acids Res. 32 (2): 598–610. doi:10.1093/nar/gkh195. PMC 373322. PMID 14752048.
  5. ↑ 5.0 5.1 5.2 Kahyo T, Nishida T, Yasuda H (September 2001). "Involvement of PIAS1 in the sumoylation of tumor suppressor p53". Mol. Cell. 8 (3): 713–8. doi:10.1016/s1097-2765(01)00349-5. PMID 11583632.
  6. ↑ Gallagher WM, Argentini M, Sierra V, Bracco L, Debussche L, Conseiller E (June 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. PMID 10380882.
  7. ↑ Liao J, Fu Y, Shuai K (May 2000). "Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction". Proc. Natl. Acad. Sci. U.S.A. 97 (10): 5267–72. doi:10.1073/pnas.97.10.5267. PMC 25817. PMID 10805787.
  8. ↑ 8.0 8.1 Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (December 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
  9. ↑ 9.0 9.1 Sapetschnig A, Rischitor G, Braun H, Doll A, Schergaut M, Melchior F, Suske G (October 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. 21 (19): 5206–15. doi:10.1093/emboj/cdf510. PMC 129032. PMID 12356736.

Further reading


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