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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Pallidin''' is a [[protein]] that in humans is encoded by the ''PLDN'' [[gene]].<ref name="pmid10610180">{{cite journal | vauthors = Huang L, Kuo YM, Gitschier J | title = The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency | journal = Nat Genet | volume = 23 | issue = 3 | pages = 329–32 | date = Dec 1999 | pmid = 10610180 | pmc =  | doi = 10.1038/15507 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLDN pallidin homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26258| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pallidin homolog (mouse)
| HGNCid = 8549
| Symbol = PLDN
| AltSymbols =; PA; PALLID
| OMIM = 604310
| ECnumber = 
| Homologene = 40841
| MGIid = 1927580
| GeneAtlas_image1 = PBB_GE_PLDN_gnf1h00125_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PLDN_gnf1h01408_at_tn.png
| Function = {{GNF_GO|id=GO:0030349 |text = syntaxin-13 binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0016081 |text = synaptic vesicle docking during exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26258
    | Hs_Ensembl = ENSG00000104164
    | Hs_RefseqProtein = NP_036520
    | Hs_RefseqmRNA = NM_012388
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 43666709
    | Hs_GenLoc_end = 43689200
    | Hs_Uniprot = Q9UL45
    | Mm_EntrezGene = 18457
    | Mm_Ensembl = ENSMUSG00000005804
    | Mm_RefseqmRNA = NM_019788
    | Mm_RefseqProtein = NP_062762
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 122429965
    | Mm_GenLoc_end = 122439539
    | Mm_Uniprot = Q5U455
  }}
}}
'''Pallidin homolog (mouse)''', also known as '''PLDN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLDN pallidin homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26258| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PLDN pallidin homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26258| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PLDN has been shown to [[Protein-protein interaction|interact]] with:
* [[BLOC1S1]],<ref name = pmid15102850>{{cite journal | vauthors = Starcevic M, Dell'Angelica EC | title = Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) | journal = J. Biol. Chem. | volume = 279 | issue = 27 | pages = 28393–401 | date = Jul 2004 | pmid = 15102850 | doi = 10.1074/jbc.M402513200 }}</ref>
* [[BLOC1S2]],<ref name = pmid15102850/>
* [[CNO (gene)|CNO]],<ref name = pmid15102850/>
* [[Dysbindin]],<ref name = pmid15102850/>
* [[MUTED]],<ref name = pmid15102850/><ref name = pmid12019270>{{cite journal | vauthors = Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC | title = BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28191–9 | date = Aug 2002 | pmid = 12019270 | doi = 10.1074/jbc.M204011200 }}</ref>
* [[SNAPAP]],<ref name = pmid15102850/> and
* [[STX12]].<ref name = pmid10610180 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Falcón-Pérez JM, Dell'Angelica EC | title = The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis | journal = Pigment Cell Res. | volume = 15 | issue = 2 | pages = 82–6 | year = 2002 | pmid = 11936273 | doi = 10.1034/j.1600-0749.2002.1r082.x }}
| citations =
* {{cite journal | vauthors = Korsgren C, Cohen CM | title = Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3 | journal = J. Biol. Chem. | volume = 263 | issue = 21 | pages = 10212–8 | year = 1988 | pmid = 2968981 | doi =  }}
*{{cite journal | author=Falcón-Pérez JM, Dell'Angelica EC |title=The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis. |journal=Pigment Cell Res. |volume=15 |issue= 2 |pages= 82-6 |year= 2002 |pmid= 11936273 |doi= }}
* {{cite journal | vauthors = Azim AC, Marfatia SM, Korsgren C, Dotimas E, Cohen CM, Chishti AH | title = Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins | journal = Biochemistry | volume = 35 | issue = 9 | pages = 3001–6 | year = 1996 | pmid = 8608138 | doi = 10.1021/bi951745y }}
*{{cite journal | author=Korsgren C, Cohen CM |title=Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3. |journal=J. Biol. Chem. |volume=263 |issue= 21 |pages= 10212-8 |year= 1988 |pmid= 2968981 |doi=  }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Azim AC, Marfatia SM, Korsgren C, ''et al.'' |title=Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins. |journal=Biochemistry |volume=35 |issue= 9 |pages= 3001-6 |year= 1996 |pmid= 8608138 |doi= 10.1021/bi951745y }}
* {{cite journal | vauthors = Risinger MA, Korsgren C, Cohen CM | title = Role of N-myristylation in targeting of band 4.2 (pallidin) in nonerythroid cells | journal = Exp. Cell Res. | volume = 229 | issue = 2 | pages = 421–31 | year = 1997 | pmid = 8986625 | doi = 10.1006/excr.1996.0387 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Risinger MA, Korsgren C, Cohen CM |title=Role of N-myristylation in targeting of band 4.2 (pallidin) in nonerythroid cells. |journal=Exp. Cell Res. |volume=229 |issue= 2 |pages= 421-31 |year= 1997 |pmid= 8986625 |doi= 10.1006/excr.1996.0387 }}
* {{cite journal | vauthors = Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC | title = BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 28191–9 | year = 2002 | pmid = 12019270 | doi = 10.1074/jbc.M204011200 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Moriyama K, Bonifacino JS | title = Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles | journal = Traffic | volume = 3 | issue = 9 | pages = 666–77 | year = 2003 | pmid = 12191018 | doi = 10.1034/j.1600-0854.2002.30908.x }}
*{{cite journal  | author=Huang L, Kuo YM, Gitschier J |title=The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 329-32 |year= 1999 |pmid= 10610180 |doi= 10.1038/15507 }}
* {{cite journal | vauthors = Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL | title = Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1) | journal = Blood | volume = 101 | issue = 11 | pages = 4402–7 | year = 2003 | pmid = 12576321 | doi = 10.1182/blood-2003-01-0020 }}
*{{cite journal | author=Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC |title=BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28191-9 |year= 2002 |pmid= 12019270 |doi= 10.1074/jbc.M204011200 }}
* {{cite journal | vauthors = Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O'Brien EP, Tinsley CL, Blake DJ, Spritz RA, Copeland NG, Jenkins NA, Amato D, Roe BA, Starcevic M, Dell'Angelica EC, Elliott RW, Mishra V, Kingsmore SF, Paylor RE, Swank RT | title = Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) | journal = Nat. Genet. | volume = 35 | issue = 1 | pages = 84–9 | year = 2003 | pmid = 12923531 | pmc = 2860733 | doi = 10.1038/ng1229 }}
*{{cite journal | author=Moriyama K, Bonifacino JS |title=Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. |journal=Traffic |volume=3 |issue= 9 |pages= 666-77 |year= 2003 |pmid= 12191018 |doi= }}
* {{cite journal | vauthors = Starcevic M, Dell'Angelica EC | title = Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) | journal = J. Biol. Chem. | volume = 279 | issue = 27 | pages = 28393–401 | year = 2004 | pmid = 15102850 | doi = 10.1074/jbc.M402513200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Ciciotte SL, Gwynn B, Moriyama K, ''et al.'' |title=Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). |journal=Blood |volume=101 |issue= 11 |pages= 4402-7 |year= 2003 |pmid= 12576321 |doi= 10.1182/blood-2003-01-0020 }}
*{{cite journal | author=Li W, Zhang Q, Oiso N, ''et al.'' |title=Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). |journal=Nat. Genet. |volume=35 |issue= 1 |pages= 84-9 |year= 2003 |pmid= 12923531 |doi= 10.1038/ng1229 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Starcevic M, Dell'Angelica EC |title=Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28393-401 |year= 2004 |pmid= 15102850 |doi= 10.1074/jbc.M402513200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-15-stub}}

Latest revision as of 18:17, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pallidin is a protein that in humans is encoded by the PLDN gene.[1][2]

Function

The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

Interactions

PLDN has been shown to interact with:

References

  1. ↑ 1.0 1.1 Huang L, Kuo YM, Gitschier J (Dec 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nat Genet. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180.
  2. ↑ 2.0 2.1 "Entrez Gene: PLDN pallidin homolog (mouse)".
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Starcevic M, Dell'Angelica EC (Jul 2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)". J. Biol. Chem. 279 (27): 28393–401. doi:10.1074/jbc.M402513200. PMID 15102850.
  4. ↑ Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC (Aug 2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules". J. Biol. Chem. 277 (31): 28191–9. doi:10.1074/jbc.M204011200. PMID 12019270.

Further reading

  • Falcón-Pérez JM, Dell'Angelica EC (2002). "The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis". Pigment Cell Res. 15 (2): 82–6. doi:10.1034/j.1600-0749.2002.1r082.x. PMID 11936273.
  • Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981.
  • Azim AC, Marfatia SM, Korsgren C, Dotimas E, Cohen CM, Chishti AH (1996). "Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins". Biochemistry. 35 (9): 3001–6. doi:10.1021/bi951745y. PMID 8608138.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Risinger MA, Korsgren C, Cohen CM (1997). "Role of N-myristylation in targeting of band 4.2 (pallidin) in nonerythroid cells". Exp. Cell Res. 229 (2): 421–31. doi:10.1006/excr.1996.0387. PMID 8986625.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC (2002). "BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules". J. Biol. Chem. 277 (31): 28191–9. doi:10.1074/jbc.M204011200. PMID 12019270.
  • Moriyama K, Bonifacino JS (2003). "Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles". Traffic. 3 (9): 666–77. doi:10.1034/j.1600-0854.2002.30908.x. PMID 12191018.
  • Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL (2003). "Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)". Blood. 101 (11): 4402–7. doi:10.1182/blood-2003-01-0020. PMID 12576321.
  • Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O'Brien EP, Tinsley CL, Blake DJ, Spritz RA, Copeland NG, Jenkins NA, Amato D, Roe BA, Starcevic M, Dell'Angelica EC, Elliott RW, Mishra V, Kingsmore SF, Paylor RE, Swank RT (2003). "Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)". Nat. Genet. 35 (1): 84–9. doi:10.1038/ng1229. PMC 2860733. PMID 12923531.
  • Starcevic M, Dell'Angelica EC (2004). "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)". J. Biol. Chem. 279 (27): 28393–401. doi:10.1074/jbc.M402513200. PMID 15102850.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.


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