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'''Olfactory receptor 3A2''' is a [[protein]] that in humans is encoded by the ''OR3A2'' [[gene]].<ref name="pmid8921386">{{cite journal | vauthors = Glusman G, Clifton S, Roe B, Lancet D | title = Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity | journal = Genomics | volume = 37 | issue = 2 | pages = 147–60 |date=Feb 1997 | pmid = 8921386 | pmc =  | doi = 10.1006/geno.1996.0536 }}</ref><ref name="pmid10673334">{{cite journal | vauthors = Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D | title = Sequence, structure, and evolution of a complete human olfactory receptor gene cluster | journal = Genomics | volume = 63 | issue = 2 | pages = 227–45 |date=Apr 2000 | pmid = 10673334 | pmc =  | doi = 10.1006/geno.1999.6030 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4995| accessdate = }}</ref>
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| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 3, subfamily A, member 2
| HGNCid = 8283
| Symbol = OR3A2
| AltSymbols =; OLFRA04; OR17-14; OR17-228; OR228
| OMIM = 
| ECnumber = 
| Homologene = 68262
| MGIid = 3030244
| GeneAtlas_image1 = PBB_GE_OR3A2_221386_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4995
    | Hs_Ensembl = ENSG00000205813
    | Hs_RefseqProtein = NP_002542
    | Hs_RefseqmRNA = NM_002551
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3128014
    | Hs_GenLoc_end = 3236337
    | Hs_Uniprot = P47893
    | Mm_EntrezGene = 258702
    | Mm_Ensembl = ENSMUSG00000063116
    | Mm_RefseqmRNA = NM_146707
    | Mm_RefseqProtein = NP_666918
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 74150477
    | Mm_GenLoc_end = 74151424
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 3, subfamily A, member 2''', also known as '''OR3A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4995| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4995| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi=  }}
*{{cite journal   |vauthors=Ben-Arie N, Lancet D, Taylor C, etal |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229–35 |year= 1994 |pmid= 8004088 |doi=10.1093/hmg/3.2.229  }}
*{{cite journal  | author=Glusman G, Clifton S, Roe B, Lancet D |title=Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. |journal=Genomics |volume=37 |issue= 2 |pages= 147-60 |year= 1997 |pmid= 8921386 |doi= 10.1006/geno.1996.0536 }}
*{{cite journal   |vauthors=Rouquier S, Taviaux S, Trask BJ, etal |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243–50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]

Latest revision as of 00:30, 7 September 2017

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SpeciesHumanMouse
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Wikidata
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Olfactory receptor 3A2 is a protein that in humans is encoded by the OR3A2 gene.[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Glusman G, Clifton S, Roe B, Lancet D (Feb 1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386.
  2. ↑ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
  3. ↑ 3.0 3.1 "Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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