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{{Infobox_gene}}
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'''Olfactory receptor 1A1''' is a [[protein]] that in humans is encoded by the ''OR1A1'' [[gene]].<ref name="pmid10673334">{{cite journal | vauthors = Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D | title = Sequence, structure, and evolution of a complete human olfactory receptor gene cluster | journal = Genomics | volume = 63 | issue = 2 | pages = 227–45 |date=Apr 2000 | pmid = 10673334 | pmc =  | doi = 10.1006/geno.1999.6030 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8383| accessdate = }}</ref>
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| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 1, subfamily A, member 1
| HGNCid = 8179
| Symbol = OR1A1
| AltSymbols =; OR17-7
| OMIM = 
| ECnumber = 
| Homologene = 8219
| MGIid = 1333770
| GeneAtlas_image1 = PBB_GE_OR1A1_221388_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8383
    | Hs_Ensembl = ENSG00000172146
    | Hs_RefseqProtein = NP_055380
    | Hs_RefseqmRNA = NM_014565
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3065665
    | Hs_GenLoc_end = 3066594
    | Hs_Uniprot = Q9P1Q5
    | Mm_EntrezGene = 258706
    | Mm_Ensembl = ENSMUSG00000070377
    | Mm_RefseqmRNA = NM_146711
    | Mm_RefseqProtein = NP_666922
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 74022468
    | Mm_GenLoc_end = 74023409
    | Mm_Uniprot = 
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'''Olfactory receptor, family 1, subfamily A, member 1''', also known as '''OR1A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8383| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8383| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8383| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal   |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 }}
*{{cite journal  | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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Latest revision as of 00:28, 7 September 2017

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SpeciesHumanMouse
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View/Edit Human

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.[1][2]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[2]

See also

References

  1. ↑ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334.
  2. ↑ 2.0 2.1 "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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