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{{Infobox_gene}}
{{PBB_Controls
'''Olfactory receptor 3A3''' is a [[protein]] that in humans is encoded by the ''OR3A3'' [[gene]].<ref name="pmid8004088">{{cite journal | vauthors = Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H | title = Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire | journal = Hum Mol Genet | volume = 3 | issue = 2 | pages = 229–35 | date = Jul 1994 | pmid = 8004088 | pmc =  | doi = 10.1093/hmg/3.2.229 }}</ref><ref name="pmid9500546">{{cite journal | vauthors = Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D | title = Distribution of olfactory receptor genes in the human genome | journal = Nat Genet | volume = 18 | issue = 3 | pages = 243–50 | date = Mar 1998 | pmid = 9500546 | pmc =  | doi = 10.1038/ng0398-243 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8392| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 3, subfamily A, member 3
| HGNCid = 8284
| Symbol = OR3A3
| AltSymbols =; OR17-137; OR17-16; OR17-201; OR3A6; OR3A7; OR3A8P
| OMIM = 
| ECnumber = 
| Homologene = 74999
| MGIid = 3030245
| GeneAtlas_image1 = PBB_GE_OR3A3_221426_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}{{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8392
    | Hs_Ensembl = ENSG00000159961
    | Hs_RefseqProtein = NP_036505
    | Hs_RefseqmRNA = NM_012373
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3270612
    | Hs_GenLoc_end = 3271577
    | Hs_Uniprot = P47888
    | Mm_EntrezGene = 258704
    | Mm_Ensembl = ENSMUSG00000054406
    | Mm_RefseqmRNA = NM_146709
    | Mm_RefseqProtein = NP_666920
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 74162830
    | Mm_GenLoc_end = 74163777
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 3, subfamily A, member 3''', also known as '''OR3A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8392| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8392| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Olfactory receptor]]
* [[Olfactory receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 8 | pages = 2584–9 | year = 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 }}
| citations =
* {{cite journal | vauthors = Gilad Y, Lancet D | title = Population differences in the human functional olfactory repertoire | journal = Mol. Biol. Evol. | volume = 20 | issue = 3 | pages = 307–14 | year = 2003 | pmid = 12644552 | doi = 10.1093/molbev/msg013 }}
*{{cite journal | author=Zody MC, Garber M, Adams DJ, ''et al.'' |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |journal=Nature |volume=440 |issue= 7087 |pages= 1045-9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 }}
* {{cite journal | vauthors = Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R | title = DEFOG: a practical scheme for deciphering families of genes | journal = Genomics | volume = 80 | issue = 3 | pages = 295–302 | year = 2003 | pmid = 12213199 | doi = 10.1006/geno.2002.6830 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
* {{cite journal | vauthors = Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D | title = Sequence, structure, and evolution of a complete human olfactory receptor gene cluster | journal = Genomics | volume = 63 | issue = 2 | pages = 227–45 | year = 2000 | pmid = 10673334 | doi = 10.1006/geno.1999.6030 }}
*{{cite journal | author=Gilad Y, Lancet D |title=Population differences in the human functional olfactory repertoire. |journal=Mol. Biol. Evol. |volume=20 |issue= 3 |pages= 307-14 |year= 2003 |pmid= 12644552 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal  | author=Rouquier S, Taviaux S, Trask BJ, ''et al.'' |title=Distribution of olfactory receptor genes in the human genome. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 243-50 |year= 1998 |pmid= 9500546 |doi= 10.1038/ng0398-243 }}
*{{cite journal  | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi=  }}
}}
{{refend}}
{{refend}}


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{{Olfactory receptors}}
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Latest revision as of 02:32, 27 October 2017

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SpeciesHumanMouse
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Olfactory receptor 3A3 is a protein that in humans is encoded by the OR3A3 gene.[1][2][3]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
  2. ↑ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546.
  3. ↑ 3.0 3.1 "Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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