Protein unc-119 homolog: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Protein unc-119 homolog A''' is a [[protein]] that in humans is encoded by the ''UNC119'' [[gene]].<ref name="pmid8576185">{{cite journal |vauthors=Higashide T, Murakami A, McLaren MJ, Inana G | title = Cloning of the cDNA for a novel photoreceptor protein | journal = J Biol Chem | volume = 271 | issue = 3 | pages = 1797–804 |date=Mar 1996 | pmid = 8576185 | pmc =  | doi =10.1074/jbc.271.3.1797  }}</ref><ref name="pmid9538874">{{cite journal |vauthors=Higashide T, McLaren MJ, Inana G | title = Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse | journal = Invest Ophthalmol Vis Sci | volume = 39 | issue = 5 | pages = 690–8 |date=Apr 1998 | pmid = 9538874 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UNC119 unc-119 homolog (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9094| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Unc-119 homolog (C. elegans)
| HGNCid = 12565
| Symbol = UNC119
| AltSymbols =; HRG4
| OMIM = 604011
| ECnumber = 
| Homologene = 3778
| MGIid = 1328357
| GeneAtlas_image1 = PBB_GE_UNC119_203271_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9094
    | Hs_Ensembl = ENSG00000109103
    | Hs_RefseqProtein = NP_005139
    | Hs_RefseqmRNA = NM_005148
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 23897852
    | Hs_GenLoc_end = 23903770
    | Hs_Uniprot = Q13432
    | Mm_EntrezGene = 22248
    | Mm_Ensembl = ENSMUSG00000002058
    | Mm_RefseqmRNA = XM_001004307
    | Mm_RefseqProtein = XP_001004307
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 78159717
    | Mm_GenLoc_end = 78165351
    | Mm_Uniprot = Q5SYM3
  }}
}}
'''Unc-119 homolog (C. elegans)''', also known as '''UNC119''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UNC119 unc-119 homolog (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9094| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is enriched in the photoreceptors of the [[retina]]. The encoded product shares strong [[Homology (biology)|homology]] with the [[Caenorhabditis elegans|C. elegans]] unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: UNC119 unc-119 homolog (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9094| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Protein unc-119 homolog has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ARL2]],<ref name = pmid12527357>{{cite journal | date = Jan 2003 |vauthors=Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G | title = Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain | journal = FEBS Lett. | volume = 534 | issue = 1-3 | pages = 26–32 | pmid = 12527357 | doi = 10.1016/S0014-5793(02)03766-3}}</ref>
* [[ARL3]],<ref name = pmid16169070>{{cite journal | date = Sep 2005 |vauthors=Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029}}</ref><ref name = pmid11303027>{{cite journal | date = Jun 2001 |vauthors=Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA | title = ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22826–37 | pmid = 11303027 | doi = 10.1074/jbc.M102359200}}</ref>
* [[CD247]],<ref name = pmid14757743/>
* [[CD4]],<ref name = pmid14757743/>
* [[FYN]],<ref name = pmid14757743/>
* [[Interleukin 5 receptor alpha subunit|IL5RA]],<ref name = pmid12496276/>
* [[LYN]],<ref name = pmid12496276>{{cite journal | date = Mar 2003 |vauthors=Cen O, Gorska MM, Stafford SJ, Sur S, Alam R | title = Identification of UNC119 as a novel activator of SRC-type tyrosine kinases | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8837–45 | pmid = 12496276 | doi = 10.1074/jbc.M208261200}}</ref>
* [[Lck]],<ref name = pmid14757743>{{cite journal | date = Feb 2004 |vauthors=Gorska MM, Stafford SJ, Cen O, Sur S, Alam R | title = Unc119, a novel activator of Lck/Fyn, is essential for T cell activation | journal = J. Exp. Med. | volume = 199 | issue = 3 | pages = 369–79 | pmid = 14757743 | pmc = 2211793 | doi = 10.1084/jem.20030589 }}</ref>  and
* [[RIBEYE]].<ref name="pmid18664567">{{cite journal |vauthors=Alpadi K, Magupalli VG, Käppel S, Köblitz L, Schwarz K, Seigel GM, Sung CH, Schmitz F | title = RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses | journal = J. Biol. Chem. | volume = 283 | issue = 39 | pages = 26461–7 | year = 2008 | pmid = 18664567 | pmc = 3258921 | doi = 10.1074/jbc.M801625200 }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Swanson DA, Chang JT, Campochiaro PA, etal |title=Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 11 |pages= 2085–94 |year= 1998 |pmid= 9761287 |doi=  }}
| citations =
*{{cite journal  |vauthors=Higashide T, Inana G |title=Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119 |journal=Genomics |volume=57 |issue= 3 |pages= 446–50 |year= 1999 |pmid= 10329014 |doi= 10.1006/geno.1999.5791 }}
*{{cite journal | author=Higashide T, Murakami A, McLaren MJ, Inana G |title=Cloning of the cDNA for a novel photoreceptor protein. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1797-804 |year= 1996 |pmid= 8576185 |doi=  }}
*{{cite journal   |vauthors=Van Valkenburgh H, Shern JF, Sharer JD, etal |title=ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22826–37 |year= 2001 |pmid= 11303027 |doi= 10.1074/jbc.M102359200 }}
*{{cite journal  | author=Higashide T, McLaren MJ, Inana G |title=Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse. |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 5 |pages= 690-8 |year= 1998 |pmid= 9538874 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Swanson DA, Chang JT, Campochiaro PA, ''et al.'' |title=Mammalian orthologs of C. elegans unc-119 highly expressed in photoreceptors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=39 |issue= 11 |pages= 2085-94 |year= 1998 |pmid= 9761287 |doi=  }}
*{{cite journal   |vauthors=Cen O, Gorska MM, Stafford SJ, etal |title=Identification of UNC119 as a novel activator of SRC-type tyrosine kinases |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8837–45 |year= 2003 |pmid= 12496276 |doi= 10.1074/jbc.M208261200 }}
*{{cite journal  | author=Higashide T, Inana G |title=Characterization of the gene for HRG4 (UNC119), a novel photoreceptor synaptic protein homologous to unc-119. |journal=Genomics |volume=57 |issue= 3 |pages= 446-50 |year= 1999 |pmid= 10329014 |doi= 10.1006/geno.1999.5791 }}
*{{cite journal   |vauthors=Kobayashi A, Kubota S, Mori N, etal |title=Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain |journal=FEBS Lett. |volume=534 |issue= 1–3 |pages= 26–32 |year= 2004 |pmid= 12527357 |doi=10.1016/S0014-5793(02)03766-3 }}
*{{cite journal | author=Van Valkenburgh H, Shern JF, Sharer JD, ''et al.'' |title=ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22826-37 |year= 2001 |pmid= 11303027 |doi= 10.1074/jbc.M102359200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Cen O, Gorska MM, Stafford SJ, ''et al.'' |title=Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8837-45 |year= 2003 |pmid= 12496276 |doi= 10.1074/jbc.M208261200 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Kobayashi A, Kubota S, Mori N, ''et al.'' |title=Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain. |journal=FEBS Lett. |volume=534 |issue= 1-3 |pages= 26-32 |year= 2004 |pmid= 12527357 |doi=  }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Vepachedu R, Gorska MM, Singhania N, etal |title=Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway |journal=J. Immunol. |volume=179 |issue= 1 |pages= 682–90 |year= 2007 |pmid= 17579091 |doi=  10.4049/jimmunol.179.1.682}}
*{{cite journal | author=Gorska MM, Stafford SJ, Cen O, ''et al.'' |title=Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. |journal=J. Exp. Med. |volume=199 |issue= 3 |pages= 369-79 |year= 2004 |pmid= 14757743 |doi= 10.1084/jem. 20030589 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Vepachedu R, Gorska MM, Singhania N, ''et al.'' |title=Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. |journal=J. Immunol. |volume=179 |issue= 1 |pages= 682-90 |year= 2007 |pmid= 17579091 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{gene-17-stub}}

Latest revision as of 15:32, 8 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein unc-119 homolog A is a protein that in humans is encoded by the UNC119 gene.[1][2][3]

Function

This gene is enriched in the photoreceptors of the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.[3]

Interactions

Protein unc-119 homolog has been shown to interact with:

References

  1. ↑ Higashide T, Murakami A, McLaren MJ, Inana G (Mar 1996). "Cloning of the cDNA for a novel photoreceptor protein". J Biol Chem. 271 (3): 1797–804. doi:10.1074/jbc.271.3.1797. PMID 8576185.
  2. ↑ Higashide T, McLaren MJ, Inana G (Apr 1998). "Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse". Invest Ophthalmol Vis Sci. 39 (5): 690–8. PMID 9538874.
  3. ↑ 3.0 3.1 "Entrez Gene: UNC119 unc-119 homolog (C. elegans)".
  4. ↑ Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G (Jan 2003). "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain". FEBS Lett. 534 (1–3): 26–32. doi:10.1016/S0014-5793(02)03766-3. PMID 12527357.
  5. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  6. ↑ Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (Jun 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027.
  7. ↑ 7.0 7.1 7.2 7.3 Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.
  8. ↑ 8.0 8.1 Cen O, Gorska MM, Stafford SJ, Sur S, Alam R (Mar 2003). "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases". J. Biol. Chem. 278 (10): 8837–45. doi:10.1074/jbc.M208261200. PMID 12496276.
  9. ↑ Alpadi K, Magupalli VG, Käppel S, Köblitz L, Schwarz K, Seigel GM, Sung CH, Schmitz F (2008). "RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses". J. Biol. Chem. 283 (39): 26461–7. doi:10.1074/jbc.M801625200. PMC 3258921. PMID 18664567.

Further reading


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