AP2S1: Difference between revisions

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Latest revision as of 18:05, 29 August 2017

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.^[1]^[2]^[3]

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.^[3]

References

↑ Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.
↑ Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.
↑ ^3.0 ^3.1 "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol. 10 (2): 220–8. doi:10.1016/S0959-440X(00)00071-3. PMID 10753805.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein". Mol. Biol. Cell. 18 (2): 414–25. doi:10.1091/mbc.E06-06-0535. PMC 1783771. PMID 17108326.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Batonick M, Favre M, Boge M, et al. (2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology. 342 (2): 190–200. doi:10.1016/j.virol.2005.08.001. PMID 16139856.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Vendeville A, Rayne F, Bonhoure A, et al. (2005). "HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses". Mol. Biol. Cell. 15 (5): 2347–60. doi:10.1091/mbc.E03-12-0921. PMC 404028. PMID 15020715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Collins BM, McCoy AJ, Kent HM, et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608.
Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins". J. Virol. 73 (2): 1350–61. PMC 103959. PMID 9882340.
Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
Kirchhausen T, Nathanson KL, Matsui W, et al. (1989). "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2612–6. doi:10.1073/pnas.86.8.2612. PMC 286967. PMID 2495531.
Kirchhausen T, Davis AC, Frucht S, et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. PMID 2040623.

External links

Human AP2S1 genome location and AP2S1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid9040778-1] Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet. 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.

[pmid9767099-2] Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.

[entrez-3] 3.0 ^3.1 "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''AP-2 complex subunit sigma''' is a [[protein]] that in humans is encoded by the ''AP2S1'' [[gene]].<ref name="pmid9040778">{{cite journal |vauthors=Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B | title = Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3 | journal = Cytogenet Cell Genet | volume = 75 | issue = 2–3 | pages = 132–5 |date=Mar 1997 | pmid = 9040778 | pmc =  | doi =  10.1159/000134463}}</ref><ref name="pmid9767099">{{cite journal |vauthors=Holzmann K, Poltl A, Sauermann G | title = A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17 | journal = Gene | volume = 220 | issue = 1–2 | pages = 39–44 |date=Nov 1998 | pmid = 9767099 | pmc =  | doi =10.1016/S0378-1119(98)00406-5  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1175| accessdate = }}</ref>
-| update_page = yes
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_AP2S1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gw5.
- | PDB = {{PDB2|1gw5}}
- | Name = Adaptor-related protein complex 2, sigma 1 subunit
- | HGNCid = 565
- | Symbol = AP2S1
- | AltSymbols =; AP17; AP17-DELTA; CLAPS2
- | OMIM = 602242
- | ECnumber =
- | Homologene = 3001
- | MGIid = 2141861
-  | GeneAtlas_image1 = PBB_GE_AP2S1_208074_s_at_tn.png
-  | GeneAtlas_image2 = PBB_GE_AP2S1_202120_x_at_tn.png
- | GeneAtlas_image3 = PBB_GE_AP2S1_211047_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
- | Component = {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0030122 |text = AP-2 adaptor complex}} {{GNF_GO|id=GO:0030662 |text = coated vesicle membrane}}
- | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0030100 |text = regulation of endocytosis}} {{GNF_GO|id=GO:0048268 |text = clathrin cage assembly}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1175
-    | Hs_Ensembl = ENSG00000042753
-    | Hs_RefseqProtein = NP_004060
-    | Hs_RefseqmRNA = NM_004069
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 52033263
-    | Hs_GenLoc_end = 52046043
-    | Hs_Uniprot = P53680
-    | Mm_EntrezGene = 232910
-    | Mm_Ensembl = ENSMUSG00000008036
-    | Mm_RefseqmRNA = NM_198613
-    | Mm_RefseqProtein = NP_941015
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 15896984
-    | Mm_GenLoc_end = 15907814
-    | Mm_Uniprot = Q3UJ76
-  }}
-}}
-'''Adaptor-related protein complex 2, sigma 1 subunit''', also known as '''AP2S1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1175| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.<ref name="entrez">{{cite web | title = Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1175| accessdate = }}</ref>
+| summary_text = One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Pearse BM, Smith CJ, Owen DJ |title=Clathrin coat construction in endocytosis. |journal=Curr. Opin. Struct. Biol. |volume=10 |issue= 2 |pages= 220-8 |year= 2000 |pmid= 10753805 |doi=  }}
+*{{cite journal  |vauthors=Pearse BM, Smith CJ, Owen DJ |title=Clathrin coat construction in endocytosis |journal=Curr. Opin. Struct. Biol. |volume=10 |issue= 2 |pages= 220–8 |year= 2000 |pmid= 10753805 |doi=10.1016/S0959-440X(00)00071-3  }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
+*{{cite journal  |vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 |display-authors=etal}}
-*{{cite journal  | author=Byland R, Vance PJ, Hoxie JA, Marsh M |title=A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. |journal=Mol. Biol. Cell |volume=18 |issue= 2 |pages= 414-25 |year= 2007 |pmid= 17108326 |doi= 10.1091/mbc.E06-06-0535 }}
+*{{cite journal  |vauthors=Byland R, Vance PJ, Hoxie JA, Marsh M |title=A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein |journal=Mol. Biol. Cell |volume=18 |issue= 2 |pages= 414–25 |year= 2007 |pmid= 17108326 |doi= 10.1091/mbc.E06-06-0535  | pmc=1783771 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
-*{{cite journal  | author=Batonick M, Favre M, Boge M, ''et al.'' |title=Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. |journal=Virology |volume=342 |issue= 2 |pages= 190-200 |year= 2006 |pmid= 16139856 |doi= 10.1016/j.virol.2005.08.001 }}
+*{{cite journal  |vauthors=Batonick M, Favre M, Boge M |title=Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2 |journal=Virology |volume=342 |issue= 2 |pages= 190–200 |year= 2006 |pmid= 16139856 |doi= 10.1016/j.virol.2005.08.001 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Vendeville A, Rayne F, Bonhoure A, ''et al.'' |title=HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2347-60 |year= 2005 |pmid= 15020715 |doi= 10.1091/mbc.E03-12-0921 }}
+*{{cite journal  |vauthors=Vendeville A, Rayne F, Bonhoure A |title=HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2347–60 |year= 2005 |pmid= 15020715 |doi= 10.1091/mbc.E03-12-0921  | pmc=404028 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Collins BM, McCoy AJ, Kent HM, ''et al.'' |title=Molecular architecture and functional model of the endocytic AP2 complex. |journal=Cell |volume=109 |issue= 4 |pages= 523-35 |year= 2002 |pmid= 12086608 |doi=  }}
+*{{cite journal  |vauthors=Collins BM, McCoy AJ, Kent HM |title=Molecular architecture and functional model of the endocytic AP2 complex |journal=Cell |volume=109 |issue= 4 |pages= 523–35 |year= 2002 |pmid= 12086608 |doi=10.1016/S0092-8674(02)00735-3  |display-authors=etal}}
-*{{cite journal  | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, ''et al.'' |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350-61 |year= 1999 |pmid= 9882340 |doi=  }}
+*{{cite journal  |vauthors=Berlioz-Torrent C, Shacklett BL, Erdtmann L |title=Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=  | pmc=103959  |display-authors=etal}}
-*{{cite journal  | author=Holzmann K, Pöltl A, Sauermann G |title=A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17. |journal=Gene |volume=220 |issue= 1-2 |pages= 39-44 |year= 1998 |pmid= 9767099 |doi=  }}
+*{{cite journal  |vauthors=Page LJ, Robinson MS |title=Targeting signals and subunit interactions in coated vesicle adaptor complexes |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 619–30 |year= 1995 |pmid= 7593184 |doi=10.1083/jcb.131.3.619  | pmc=2120623  }}
-*{{cite journal  | author=Winterpacht A, Endele S, Enklaar T, ''et al.'' |title=Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3. |journal=Cytogenet. Cell Genet. |volume=75 |issue= 2-3 |pages= 132-5 |year= 1997 |pmid= 9040778 |doi=  }}
+*{{cite journal  |vauthors=Kirchhausen T, Nathanson KL, Matsui W |title=Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 8 |pages= 2612–6 |year= 1989 |pmid= 2495531 |doi=10.1073/pnas.86.8.2612  | pmc=286967  |display-authors=etal}}
-*{{cite journal  | author=Page LJ, Robinson MS |title=Targeting signals and subunit interactions in coated vesicle adaptor complexes. |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 619-30 |year= 1995 |pmid= 7593184 |doi=  }}
+*{{cite journal  |vauthors=Kirchhausen T, Davis AC, Frucht S |title=AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11153–7 |year= 1991 |pmid= 2040623 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Kirchhausen T, Nathanson KL, Matsui W, ''et al.'' |title=Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 8 |pages= 2612-6 |year= 1989 |pmid= 2495531 |doi=  }}
-*{{cite journal  | author=Kirchhausen T, Davis AC, Frucht S, ''et al.'' |title=AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11153-7 |year= 1991 |pmid= 2040623 |doi=  }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=1175}}
+==External links==
+* {{UCSC gene info|AP2S1}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-19-stub}}
-{{WikiDoc Sources}}

AP2S1: Difference between revisions

Latest revision as of 18:05, 29 August 2017

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