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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related''' is a [[protein]] that in humans is encoded by the ''HMG20B'' [[gene]].<ref name="pmid10773667">{{cite journal | vauthors = Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B | title = HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression | journal = Cytogenetics and Cell Genetics | volume = 88 | issue = 1-2 | pages = 62–7 | date = Jun 2000 | pmid = 10773667 | pmc =  | doi = 10.1159/000015486 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HMG20B high-mobility group 20B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10362| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HMG20B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2crj.
| PDB = {{PDB2|2crj}}
| Name = High-mobility group 20B
| HGNCid = 5002
| Symbol = HMG20B
| AltSymbols =; BRAF25; BRAF35; FLJ26127; HMGX2; PP7706; SMARCE1r; SOXL; pp8857
| OMIM = 605535
| ECnumber = 
| Homologene = 74949
| MGIid = 1341190
| GeneAtlas_image1 = PBB_GE_HMG20B_210719_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HMG20B_209113_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004812 |text = aminoacyl-tRNA ligase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006418 |text = tRNA aminoacylation for protein translation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10362
    | Hs_Ensembl = ENSG00000064961
    | Hs_RefseqProtein = NP_006330
    | Hs_RefseqmRNA = NM_006339
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 3523955
    | Hs_GenLoc_end = 3530073
    | Hs_Uniprot = Q9P0W2
    | Mm_EntrezGene = 15353
    | Mm_Ensembl = ENSMUSG00000020232
    | Mm_RefseqmRNA = NM_010440
    | Mm_RefseqProtein = NP_034570
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80749181
    | Mm_GenLoc_end = 80753539
    | Mm_Uniprot = Q05DT2
  }}
}}
'''High-mobility group 20B''', also known as '''HMG20B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HMG20B high-mobility group 20B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10362| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
HMG20B has been shown to [[Protein-protein interaction|interact]] with:
{{reflist|2}}
* [[BRCA2]],<ref name=pmid12032298/><ref name=pmid11207365>{{cite journal | vauthors = Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R | title = A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression | journal = Cell | volume = 104 | issue = 2 | pages = 247–57 | date = January 2001 | pmid = 11207365 | doi = 10.1016/S0092-8674(01)00209-4 }}</ref>
==Further reading==
* [[HDAC1]],<ref name=pmid12032298>{{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7420–5 | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 }}</ref>
* [[Histone deacetylase 2|HDAC2]],<ref name=pmid12032298/><ref name=pmid12493763>{{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = February 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}</ref>
* [[KIF4A]],<ref name=pmid12809554>{{cite journal | vauthors = Lee YM, Kim W | title = Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 | journal = The Biochemical Journal | volume = 374 | issue = Pt 2 | pages = 497–503 | date = September 2003 | pmid = 12809554 | pmc = 1223617 | doi = 10.1042/BJ20030452 }}</ref>
* [[PHF21A]],<ref name=pmid12032298/><ref name=pmid15325272>{{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochemical and Biophysical Research Communications | volume = 322 | issue = 2 | pages = 601–8 | date = September 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}</ref> and
* [[RCOR1]].<ref name=pmid12032298/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wattler F, Wattler S, Kelly M, Skinner HB, Nehls M | title = Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family | journal = Genomics | volume = 60 | issue = 2 | pages = 172–8 | date = September 1999 | pmid = 10486208 | doi = 10.1006/geno.1999.5913 }}
| citations =
* {{cite journal | vauthors = Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R | title = A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression | journal = Cell | volume = 104 | issue = 2 | pages = 247–57 | date = January 2001 | pmid = 11207365 | doi = 10.1016/S0092-8674(01)00209-4 }}
*{{cite journal | author=Wattler F, Wattler S, Kelly M, ''et al.'' |title=Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family. |journal=Genomics |volume=60 |issue= 2 |pages= 172-8 |year= 1999 |pmid= 10486208 |doi= 10.1006/geno.1999.5913 }}
* {{cite journal | vauthors = Lee YM, Shin H, Choi W, Ahn S, Kim W | title = Characterization of human SMARCE1r high-mobility-group protein | journal = Biochimica et Biophysica Acta | volume = 1574 | issue = 3 | pages = 269–76 | date = April 2002 | pmid = 11997092 | doi = 10.1016/s0167-4781(01)00373-6 }}
*{{cite journal | author=Sumoy L, Carim L, Escarceller M, ''et al.'' |title=HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 62-7 |year= 2000 |pmid= 10773667 |doi=  }}
* {{cite journal | vauthors = Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R | title = A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7420–5 | date = May 2002 | pmid = 12032298 | pmc = 124246 | doi = 10.1073/pnas.112008599 }}
*{{cite journal  | author=Marmorstein LY, Kinev AV, Chan GK, ''et al.'' |title=A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. |journal=Cell |volume=104 |issue= 2 |pages= 247-57 |year= 2001 |pmid= 11207365 |doi= }}
* {{cite journal | vauthors = Wang C, McCarty IM, Balazs L, Li Y, Steiner MS | title = Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35 | journal = Biochemical and Biophysical Research Communications | volume = 295 | issue = 1 | pages = 129–35 | date = July 2002 | pmid = 12083779 | doi = 10.1016/S0006-291X(02)00624-1 }}
*{{cite journal | author=Lee YM, Shin H, Choi W, ''et al.'' |title=Characterization of human SMARCE1r high-mobility-group protein. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 269-76 |year= 2002 |pmid= 11997092 |doi= }}
* {{cite journal | vauthors = Wang C, McCarty IM, Balazs L, Li Y, Steiner MS | title = Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens | journal = Biochemical and Biophysical Research Communications | volume = 295 | issue = 1 | pages = 136–41 | date = July 2002 | pmid = 12083780 | doi = 10.1016/S0006-291X(02)00625-3 }}
*{{cite journal | author=Hakimi MA, Bochar DA, Chenoweth J, ''et al.'' |title=A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7420-5 |year= 2002 |pmid= 12032298 |doi= 10.1073/pnas.112008599 }}
* {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = February 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
*{{cite journal | author=Wang C, McCarty IM, Balazs L, ''et al.'' |title=Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 1 |pages= 129-35 |year= 2002 |pmid= 12083779 |doi= }}
* {{cite journal | vauthors = Lee YM, Kim W | title = Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35 | journal = The Biochemical Journal | volume = 374 | issue = Pt 2 | pages = 497–503 | date = September 2003 | pmid = 12809554 | pmc = 1223617 | doi = 10.1042/BJ20030452 }}
*{{cite journal | author=Wang C, McCarty IM, Balazs L, ''et al.'' |title=Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 1 |pages= 136-41 |year= 2002 |pmid= 12083780 |doi= }}
* {{cite journal | vauthors = Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T | title = Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression | journal = Biochemical and Biophysical Research Communications | volume = 322 | issue = 2 | pages = 601–8 | date = September 2004 | pmid = 15325272 | doi = 10.1016/j.bbrc.2004.07.163 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Hakimi MA, Dong Y, Lane WS, ''et al.'' |title=A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7234-9 |year= 2003 |pmid= 12493763 |doi= 10.1074/jbc.M208992200 }}
*{{cite journal | author=Lee YM, Kim W |title=Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. |journal=Biochem. J. |volume=374 |issue= Pt 2 |pages= 497-503 |year= 2003 |pmid= 12809554 |doi= 10.1042/BJ20030452 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  | author=Iwase S, Januma A, Miyamoto K, ''et al.'' |title=Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression. |journal=Biochem. Biophys. Res. Commun. |volume=322 |issue= 2 |pages= 601-8 |year= 2004 |pmid= 15325272 |doi= 10.1016/j.bbrc.2004.07.163 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{UCSC genome browser|HMG20B}}
* {{UCSC gene details|HMG20B}}
{{PDB Gallery|geneid=10362}}


{{gene-19-stub}}
{{gene-19-stub}}
{{WikiDoc Sources}}

Latest revision as of 13:52, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.[1][2]


Interactions

HMG20B has been shown to interact with:

References

  1. ↑ Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenetics and Cell Genetics. 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667.
  2. ↑ "Entrez Gene: HMG20B high-mobility group 20B".
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
  4. ↑ Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365.
  5. ↑ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
  6. ↑ Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
  7. ↑ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Further reading

  • Wattler F, Wattler S, Kelly M, Skinner HB, Nehls M (September 1999). "Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family". Genomics. 60 (2): 172–8. doi:10.1006/geno.1999.5913. PMID 10486208.
  • Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365.
  • Lee YM, Shin H, Choi W, Ahn S, Kim W (April 2002). "Characterization of human SMARCE1r high-mobility-group protein". Biochimica et Biophysica Acta. 1574 (3): 269–76. doi:10.1016/s0167-4781(01)00373-6. PMID 11997092.
  • Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
  • Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (July 2002). "Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35". Biochemical and Biophysical Research Communications. 295 (1): 129–35. doi:10.1016/S0006-291X(02)00624-1. PMID 12083779.
  • Wang C, McCarty IM, Balazs L, Li Y, Steiner MS (July 2002). "Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens". Biochemical and Biophysical Research Communications. 295 (1): 136–41. doi:10.1016/S0006-291X(02)00625-3. PMID 12083780.
  • Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
  • Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
  • Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links


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