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{{Infobox_gene}}
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'''GTP-binding protein Rhes''' is a [[protein]] that in humans is encoded by the ''RASD2'' [[gene]].<ref name="pmid10947988">{{cite journal | vauthors = St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW | title = Genes expressed in human tumor endothelium | journal = Science | volume = 289 | issue = 5482 | pages = 1197–202 |date=Aug 2000 | pmid = 10947988 | pmc =  | doi =10.1126/science.289.5482.1197 }}</ref><ref name="pmid10467249">{{cite journal | vauthors = Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG | title = Rhes: A striatal-specific Ras homolog related to Dexras1 | journal = J Neurosci Res | volume = 57 | issue = 6 | pages = 782–8 |date=Oct 1999 | pmid = 10467249 | pmc = | doi =10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9  }}</ref><ref name="pmid14724584">{{cite journal | vauthors = Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J | title = The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors | journal = Oncogene | volume = 23 | issue = 2 | pages = 559–68 |date=Jan 2004 | pmid = 14724584 | pmc =  | doi = 10.1038/sj.onc.1207161 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RASD2 RASD family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23551| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = RASD family, member 2
| HGNCid = 18229
| Symbol = RASD2
| AltSymbols =; MGC:4834; Rhes; TEM2
| OMIM =
| ECnumber =
  | Homologene = 8628
  | MGIid = 1922391
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0016020 |text = membrane}}  
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23551
    | Hs_Ensembl = ENSG00000100302
    | Hs_RefseqProtein = NP_055125
    | Hs_RefseqmRNA = NM_014310
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 34267296
    | Hs_GenLoc_end = 34279987
    | Hs_Uniprot = Q96D21
    | Mm_EntrezGene = 75141
    | Mm_Ensembl = ENSMUSG00000034472
    | Mm_RefseqmRNA = XM_204287
    | Mm_RefseqProtein = XP_204287
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 78110016
    | Mm_GenLoc_end = 78120185
    | Mm_Uniprot = Q8JZW1
  }}
}}
'''RASD family, member 2''', also known as '''RASD2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RASD2 RASD family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23551| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.<ref name="entrez">{{cite web | title = Entrez Gene: RASD2 RASD family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23551| accessdate = }}</ref>
| summary_text = This gene encodes a Ras-related protein that is produced largely in the [[striatum]]. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Falk JD, Vargiu P, Foye PE, ''et al.'' |title=Rhes: A striatal-specific Ras homolog related to Dexras1. |journal=J. Neurosci. Res. |volume=57 |issue= 6 |pages= 782-8 |year= 1999 |pmid= 10467249 |doi=  }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Chan SL, Monks LK, Gao H, etal |title=Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic β-cell |journal=Br. J. Pharmacol. |volume=136 |issue= 1 |pages= 31–6 |year= 2002 |pmid= 11976265 |doi= 10.1038/sj.bjp.0704680 | pmc=1762110 }}
*{{cite journal | author=St Croix B, Rago C, Velculescu V, ''et al.'' |title=Genes expressed in human tumor endothelium. |journal=Science |volume=289 |issue= 5482 |pages= 1197-202 |year= 2000 |pmid= 10947988 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Chan SL, Monks LK, Gao H, ''et al.'' |title=Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. |journal=Br. J. Pharmacol. |volume=136 |issue= 1 |pages= 31-6 |year= 2002 |pmid= 11976265 |doi= 10.1038/sj.bjp.0704680 }}
*{{cite journal   |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Vargiu P, De Abajo R, Garcia-Ranea JA, ''et al.'' |title=The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. |journal=Oncogene |volume=23 |issue= 2 |pages= 559-68 |year= 2004 |pmid= 14724584 |doi= 10.1038/sj.onc.1207161 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | vauthors=Taylor JP, Jackson DA, Morgan NG, Chan SL |title=Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 2 |pages= 809–15 |year= 2006 |pmid= 16945334 |doi= 10.1016/j.bbrc.2006.08.102 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Agretti P, De Marco G, Pinchera A, etal |title=Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells |journal=J. Endocrinol. Invest. |volume=30 |issue= 4 |pages= 279–84 |year= 2007 |pmid= 17556863 |doi=  10.1007/bf03346294}}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Taylor JP, Jackson DA, Morgan NG, Chan SL |title=Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 2 |pages= 809-15 |year= 2006 |pmid= 16945334 |doi= 10.1016/j.bbrc.2006.08.102 }}
*{{cite journal | author=Agretti P, De Marco G, Pinchera A, ''et al.'' |title=Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells. |journal=J. Endocrinol. Invest. |volume=30 |issue= 4 |pages= 279-84 |year= 2007 |pmid= 17556863 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 08:56, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.[1][2][3][4]

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[4]

References

  1. ↑ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988.
  2. ↑ Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (Oct 1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res. 57 (6): 782–8. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249.
  3. ↑ Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584.
  4. ↑ 4.0 4.1 "Entrez Gene: RASD2 RASD family, member 2".

Further reading



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