DBF4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Protein DBF4 homolog A''' is a [[protein]] that is encoded by the ''DBF4'' [[gene]] in humans.<ref name="pmid10373557">{{cite journal | vauthors = Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H | title = A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 7 | pages = 5083–95 | date = Jul 1999 | pmid = 10373557 | pmc = 84351 | doi =  }}</ref><ref name="pmid10517317">{{cite journal | vauthors = Lepke M, Pütter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F | title = Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes | journal = Molecular & General Genetics | volume = 262 | issue = 2 | pages = 220–9 | date = Sep 1999 | pmid = 10517317 | pmc = | doi = 10.1007/s004380051078 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10926| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = DBF4 homolog (S. cerevisiae)
| HGNCid = 17364
| Symbol = DBF4
| AltSymbols =; ASK; DBF4A
| OMIM = 604281
| ECnumber = 
| Homologene = 40892
| MGIid = 1351328
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000082 |text = G1/S transition of mitotic cell cycle}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10926
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_006707
    | Hs_RefseqmRNA = NM_006716
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 27214
    | Mm_Ensembl = ENSMUSG00000002297
    | Mm_RefseqmRNA = NM_013726
    | Mm_RefseqProtein = NP_038754
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 8403001
    | Mm_GenLoc_end = 8428612
    | Mm_Uniprot = Q80YS2
  }}
}}
'''DBF4 homolog (S. cerevisiae)''', also known as '''DBF4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10926| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
DBF4 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[Cell division cycle 7-related protein kinase]],<ref name="pmid10373557"/><ref name = pmid12614612/><ref name = pmid10523313>{{cite journal | vauthors = Jiang W, McDonald D, Hope TJ, Hunter T | title = Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5703–13 | date = Oct 1999 | pmid = 10523313 | pmc = 1171637 | doi = 10.1093/emboj/18.20.5703 }}</ref>
| section_title =  
* [[MCM3]],<ref name = pmid12614612/>
| summary_text =  
* [[MCM7]],<ref name = pmid12614612/>  
}}
* [[ORC2L]],<ref name = pmid12614612>{{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = Journal of Molecular Biology | volume = 327 | issue = 1 | pages = 111–28 | date = Mar 2003 | pmid = 12614612 | doi = 10.1016/s0022-2836(03)00079-2}}</ref>  and
* [[ORC6L]].<ref name = pmid12614612/>


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Kumagai H, Sato N, Yamada M, ''et al.'' |title=A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5083-95 |year= 1999 |pmid= 10373557 |doi=  }}
*{{cite journal  | author=Lepke M, Pütter V, Staib C, ''et al.'' |title=Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes. |journal=Mol. Gen. Genet. |volume=262 |issue= 2 |pages= 220-9 |year= 1999 |pmid= 10517317 |doi=  }}
*{{cite journal  | author=Jiang W, McDonald D, Hope TJ, Hunter T |title=Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5703-13 |year= 1999 |pmid= 10523313 |doi= 10.1093/emboj/18.20.5703 }}
*{{cite journal  | author=Yamada M, Sato N, Taniyama C, ''et al.'' |title=A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27668-81 |year= 2002 |pmid= 12015319 |doi= 10.1074/jbc.M202884200 }}
*{{cite journal  | author=Wu X, Lee H |title=Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements. |journal=Oncogene |volume=21 |issue= 51 |pages= 7786-96 |year= 2002 |pmid= 12420215 |doi= 10.1038/sj.onc.1205914 }}
*{{cite journal  | author=Duncker BP, Shimada K, Tsai-Pflugfelder M, ''et al.'' |title=An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16087-92 |year= 2003 |pmid= 12441400 |doi= 10.1073/pnas.252093999 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Costanzo V, Shechter D, Lupardus PJ, ''et al.'' |title=An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 203-13 |year= 2003 |pmid= 12535533 |doi=  }}
*{{cite journal  | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111-28 |year= 2003 |pmid= 12614612 |doi=  }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Schnepp RW, Hou Z, Wang H, ''et al.'' |title=Functional interaction between tumor suppressor menin and activator of S-phase kinase. |journal=Cancer Res. |volume=64 |issue= 18 |pages= 6791-6 |year= 2004 |pmid= 15374998 |doi= 10.1158/0008-5472.CAN-04-0724 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Gérard A, Koundrioukoff S, Ramillon V, ''et al.'' |title=The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen. |journal=EMBO Rep. |volume=7 |issue= 8 |pages= 817-23 |year= 2006 |pmid= 16826239 |doi= 10.1038/sj.embor.7400750 }}
*{{cite journal  | author=Tsuji T, Ficarro SB, Jiang W |title=Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells. |journal=Mol. Biol. Cell |volume=17 |issue= 10 |pages= 4459-72 |year= 2007 |pmid= 16899510 |doi= 10.1091/mbc.E06-03-0241 }}
*{{cite journal  | author=Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, ''et al.'' |title=Cdc7-Dbf4 and the human S checkpoint response to UVC. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9458-68 |year= 2007 |pmid= 17276990 |doi= 10.1074/jbc.M611292200 }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin| 2}}
* {{cite journal | vauthors = Jiang W, McDonald D, Hope TJ, Hunter T | title = Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5703–13 | date = Oct 1999 | pmid = 10523313 | pmc = 1171637 | doi = 10.1093/emboj/18.20.5703 }}
* {{cite journal | vauthors = Yamada M, Sato N, Taniyama C, Ohtani K, Arai K, Masai H | title = A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27668–81 | date = Aug 2002 | pmid = 12015319 | doi = 10.1074/jbc.M202884200 }}
* {{cite journal | vauthors = Wu X, Lee H | title = Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements | journal = Oncogene | volume = 21 | issue = 51 | pages = 7786–96 | date = Nov 2002 | pmid = 12420215 | doi = 10.1038/sj.onc.1205914 }}
* {{cite journal | vauthors = Duncker BP, Shimada K, Tsai-Pflugfelder M, Pasero P, Gasser SM | title = An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 25 | pages = 16087–92 | date = Dec 2002 | pmid = 12441400 | pmc = 138569 | doi = 10.1073/pnas.252093999 }}
* {{cite journal | vauthors = Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J | title = An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication | journal = Molecular Cell | volume = 11 | issue = 1 | pages = 203–13 | date = Jan 2003 | pmid = 12535533 | doi = 10.1016/S1097-2765(02)00799-2 }}
* {{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = Journal of Molecular Biology | volume = 327 | issue = 1 | pages = 111–28 | date = Mar 2003 | pmid = 12614612 | doi = 10.1016/S0022-2836(03)00079-2 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Schnepp RW, Hou Z, Wang H, Petersen C, Silva A, Masai H, Hua X | title = Functional interaction between tumor suppressor menin and activator of S-phase kinase | journal = Cancer Research | volume = 64 | issue = 18 | pages = 6791–6 | date = Sep 2004 | pmid = 15374998 | doi = 10.1158/0008-5472.CAN-04-0724 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Gérard A, Koundrioukoff S, Ramillon V, Sergère JC, Mailand N, Quivy JP, Almouzni G | title = The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen | journal = EMBO Reports | volume = 7 | issue = 8 | pages = 817–23 | date = Aug 2006 | pmid = 16826239 | pmc = 1525143 | doi = 10.1038/sj.embor.7400750 }}
* {{cite journal | vauthors = Tsuji T, Ficarro SB, Jiang W | title = Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells | journal = Molecular Biology of the Cell | volume = 17 | issue = 10 | pages = 4459–72 | date = Oct 2006 | pmid = 16899510 | pmc = 1635350 | doi = 10.1091/mbc.E06-03-0241 }}
* {{cite journal | vauthors = Heffernan TP, Unsal-Kaçmaz K, Heinloth AN, Simpson DA, Paules RS, Sancar A, Cordeiro-Stone M, Kaufmann WK | title = Cdc7-Dbf4 and the human S checkpoint response to UVC | journal = The Journal of Biological Chemistry | volume = 282 | issue = 13 | pages = 9458–68 | date = Mar 2007 | pmid = 17276990 | pmc = 1839878 | doi = 10.1074/jbc.M611292200 }}
{{Refend}}
 
[[Category:Zinc finger proteins]]
 
 
{{Protein-stub}}

Latest revision as of 18:15, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.[1][2][3]

Interactions

DBF4 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H (Jul 1999). "A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells". Molecular and Cellular Biology. 19 (7): 5083–95. PMC 84351. PMID 10373557.
  2. ↑ Lepke M, Pütter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I, Schmid M, Grummt F (Sep 1999). "Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes". Molecular & General Genetics. 262 (2): 220–9. doi:10.1007/s004380051078. PMID 10517317.
  3. ↑ "Entrez Gene: DBF4 DBF4 homolog (S. cerevisiae)".
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
  5. ↑ Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal. 18 (20): 5703–13. doi:10.1093/emboj/18.20.5703. PMC 1171637. PMID 10523313.

Further reading


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