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{{Infobox_gene}}
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'''Olfactory receptor 2K2''' is a [[protein]] that in humans is encoded by the ''OR2K2'' [[gene]].<ref name="pmid1370859">{{cite journal | vauthors = Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J| title = Expression of members of the putative olfactory receptor gene family in mammalian germ cells | journal = Nature | volume = 355 | issue = 6359 | pages = 453–5 |date=Mar 1992 | pmid = 1370859 | pmc =  | doi = 10.1038/355453a0 |display-authors=etal}}</ref><ref name="pmid17010214">{{cite journal | vauthors = Aloni R, Olender T, Lancet D | title = Ancient genomic architecture for mammalian olfactory receptor clusters | journal = Genome Biol | volume = 7 | issue = 10 | pages = R88 |date=Jan 2007 | pmid = 17010214 | pmc = 1794568 | doi = 10.1186/gb-2006-7-10-r88 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26248| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 2, subfamily K, member 2
| HGNCid = 8264
| Symbol = OR2K2
| AltSymbols =; HSHTPCRH06; HTPCRH06; MGC133152; OR2AN1P; OR2AR1P
| OMIM =
| ECnumber =
| Homologene = 17436
| MGIid = 3030101
| GeneAtlas_image1 = PBB_GE_OR2K2_gnf1h11040_at_tn.png
  | GeneAtlas_image2 = PBB_GE_OR2K2_gnf1h11045_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26248
    | Hs_Ensembl = ENSG00000171133
    | Hs_RefseqProtein = NP_995581
    | Hs_RefseqmRNA = NM_205859
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 113129584
    | Hs_GenLoc_end = 113130621
    | Hs_Uniprot = Q8NGT1
    | Mm_EntrezGene = 258922
    | Mm_Ensembl = ENSMUSG00000043385
    | Mm_RefseqmRNA = NM_146920
    | Mm_RefseqProtein = NP_667131
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 58878833
    | Mm_GenLoc_end = 58879774
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 2, subfamily K, member 2''', also known as '''OR2K2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26248| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26248| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the [[human nose|nose]], to initiate a neuronal response that triggers the perception of a [[Odor|smell]]. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26248| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Parmentier M, Libert F, Schurmans S, ''et al.'' |title=Expression of members of the putative olfactory receptor gene family in mammalian germ cells. |journal=Nature |volume=355 |issue= 6359 |pages= 453-5 |year= 1992 |pmid= 1370859 |doi= 10.1038/355453a0 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Aloni R, Olender T, Lancet D |title=Ancient genomic architecture for mammalian olfactory receptor clusters. |journal=Genome Biol. |volume=7 |issue= 10 |pages= R88 |year= 2007 |pmid= 17010214 |doi= 10.1186/gb-2006-7-10-r88 }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]

Latest revision as of 00:30, 7 September 2017

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SpeciesHumanMouse
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Wikidata
View/Edit Human

Olfactory receptor 2K2 is a protein that in humans is encoded by the OR2K2 gene.[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
  2. ↑ Aloni R, Olender T, Lancet D (Jan 2007). "Ancient genomic architecture for mammalian olfactory receptor clusters". Genome Biol. 7 (10): R88. doi:10.1186/gb-2006-7-10-r88. PMC 1794568. PMID 17010214.
  3. ↑ 3.0 3.1 "Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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