Intussusception causes: Difference between revisions

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{{Intussusception}}
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==Overview==
==Overview==
Common causes of intussusception in children can be divided into idiopathic and pathologic. Idiopathic causes include seasonal [[viral gastroenteritis]], [[Rotavirus vaccine (patient information)|rotavirus vaccine]], [[adenovirus infection]], and [[bacterial enteritis]]. Pathologic causes of intussusception in children include [[Henoch-Schönlein purpura|Henoch-Schonlein purpura]], [[cystic fibrosis]], [[Celiac disease]], [[Crohn's disease]], [[Meckel's diverticulum]], [[Polyp|polyps]], duplication cysts, and [[lymphoma]]. Intussusception in adults is mostly due to a pathologic lead point. Non-idiopathic intestinal causes for intussusception in adults can further be divided into [[benign]] and [[malignant]] [[enteric]] causes, and [[benign]] and [[malignant]] [[Colon|colonic]] causes.
==Causes==
==Causes==
Intussusception is caused by part of the intestine being pulled inward into itself. This can block the passage of food through the intestine. If the blood supply is cut off, the segment of intestine pulled inside can die.
* Causes in children
** Idiopathic:
*** Seasonal [[viral gastroenteritis]]<ref name="pmid17766518">{{cite journal |vauthors=Buettcher M, Baer G, Bonhoeffer J, Schaad UB, Heininger U |title=Three-year surveillance of intussusception in children in Switzerland |journal=Pediatrics |volume=120 |issue=3 |pages=473–80 |year=2007 |pmid=17766518 |doi=10.1542/peds.2007-0035 |url=}}</ref>
*** [[Rotavirus vaccine (patient information)|Rotavirus vaccine]] <ref name="pmid26209838">{{cite journal |vauthors=Shimabukuro TT, Nguyen M, Martin D, DeStefano F |title=Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS) |journal=Vaccine |volume=33 |issue=36 |pages=4398–405 |year=2015 |pmid=26209838 |pmc=4632204 |doi=10.1016/j.vaccine.2015.07.035 |url=}}</ref>
*** [[Adenovirus infection|Adenovirus]] <ref name="pmid17011313">{{cite journal |vauthors=Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, Barnett P, Bishop RF, Robins-Browne R, Carlin JB |title=Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus |journal=J. Pediatr. |volume=149 |issue=4 |pages=452–60 |year=2006 |pmid=17011313 |doi=10.1016/j.jpeds.2006.04.010 |url=}}</ref>
*** [[Bacterial]] enteritis
** Pathologic
*** [[Henoch-Schönlein purpura]] <ref name="pmid18351468">{{cite journal |vauthors=Ebert EC |title=Gastrointestinal manifestations of Henoch-Schonlein Purpura |journal=Dig. Dis. Sci. |volume=53 |issue=8 |pages=2011–9 |year=2008 |pmid=18351468 |doi=10.1007/s10620-007-0147-0 |url=}}</ref>
*** [[Cystic fibrosis]]
*** [[Celiac disease]]
*** [[Crohn's disease]] <ref name="pmid1573498">{{cite journal |vauthors=Cohen DM, Conard FU, Treem WR, Hyams JS |title=Jejunojejunal intussusception in Crohn's disease |journal=J. Pediatr. Gastroenterol. Nutr. |volume=14 |issue=1 |pages=101–3 |year=1992 |pmid=1573498 |doi= |url=}}</ref> <ref name="pmid19529808">{{cite journal |vauthors=López-Tomassetti Fernández EM, Lorenzo Rocha N, Arteaga González I, Carrillo Pallarés A |title=Ileoileal intussusception as initial manifestation of Crohn's disease |journal=Mcgill J Med |volume=9 |issue=1 |pages=34–7 |year=2006 |pmid=19529808 |pmc=2687895 |doi= |url=}}</ref>
*** [[Meckel's diverticulum]]
*** [[Polyp|Polyps]]
*** Duplication cysts
*** [[Lymphoma]]
<br>
 
{{Family tree/start}}
{{Family tree | | | | | | | | | | | | | | | | B01 | | | |B01= Children}}
{{Family tree | | | | | | | | | | | | | |,|-|-|^|-|-|.| | }}
{{Family tree | | | | | | | | | | | | | C01 | | | | C02 |C01= Idiopathic- no lead point| C02= Pathologic- Lead point}}
{{Family tree/end}}
 
{| class="wikitable sortable"
! colspan="4" align="center" style="background:#4479BA; color: #FFFFFF;" + |<big>Causes of nonidiopathic adult intestinal intussusception*</big>
|-
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Enteric (benign)
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Enteric (malignant)
! align="center" style="background:#4479BA; color: #FFFFFF;" + |'''Colonic (benign)'''
! align="center" style="background:#4479BA; color: #FFFFFF;" + |'''Colonic (malignant)'''
|-
|
* Adhesions
* [[Adenoma]]
* [[Celiac disease]]
* [[Crohn's disease]]
* [[Endometriosis]]
* Malignant stromal ([[Gastrointestinal stromal tumor|GIST]]) tumor
* [[Hamartoma]]
* [[Hemangioma]]
* Inflammatory polyp
* [[Kaposi's sarcoma]]
* [[Lipoma]]
* [[Meckel's diverticulum]]
* [[Neurofibroma]]
* [[Peutz–Jeghers syndrome|Peutz–Jegher polyp]]
* [[Tuberculosis]]
* [[Submucosal]] [[hemorrhages]] from unregulated [[anticoagulation]]
|
* [[Adenocarcinoma]]
* [[Carcinoid tumor]]
* [[Leiomyosarcoma]]
* [[Lymphoma]]
* [[Metastatic carcinomas|Metastatic carcinoma]] ([[melanoma]] most common)
* [[Malignant]] [[Gastrointestinal stromal tumor|GIST]]
* [[Neuroendocrine tumors|Neuroendocrine tumor]]
|
* [[Adenoma]]
* Inflammatory pseudopolyp
* [[Lipoma]]
|
* [[Adenocarcinoma]]
* [[Lymphoma]]
* [[Sarcoma]]
|}
<nowiki>*</nowiki>Adopted from Clinics in Colon and Rectal Surgery 2017<ref name="urlThieme E-Journals - Clinics in Colon and Rectal Surgery / Abstract">{{cite web |url=http://dx.doi.org/+10.1055/s-0036-1593429 |title=Thieme E-Journals - Clinics in Colon and Rectal Surgery / Abstract |format= |work= |accessdate=}}</ref>


The pressure created by the walls of the intestine pressing together causes:
==References==
* Decreased blood flow
{{reflist|2}}
* [[Irritation]]
* [[Swelling]]


The intestine can die, and the patient can have significant bleeding. If a hole occurs, [[infection]], [[shock]], and [[dehydration]] can take place very rapidly.
[[Category:Gastroenterology]]
[[Category:Surgery]]


The cause of intussusception is not known, although viral infections may be responsible in some cases. Sometimes a [[lymph node]], [[polyp]], or [[tumor]] can trigger the problem. The older the child, the more likely such a trigger will be found.
{{WS}}
{{WH}}

Latest revision as of 04:21, 8 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]

Overview

Common causes of intussusception in children can be divided into idiopathic and pathologic. Idiopathic causes include seasonal viral gastroenteritis, rotavirus vaccine, adenovirus infection, and bacterial enteritis. Pathologic causes of intussusception in children include Henoch-Schonlein purpura, cystic fibrosis, Celiac disease, Crohn's disease, Meckel's diverticulum, polyps, duplication cysts, and lymphoma. Intussusception in adults is mostly due to a pathologic lead point. Non-idiopathic intestinal causes for intussusception in adults can further be divided into benign and malignant enteric causes, and benign and malignant colonic causes.

Causes


 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Children
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Idiopathic- no lead point
 
 
 
Pathologic- Lead point
Causes of nonidiopathic adult intestinal intussusception*
Enteric (benign) Enteric (malignant) Colonic (benign) Colonic (malignant)

*Adopted from Clinics in Colon and Rectal Surgery 2017[7]

References

  1. Buettcher M, Baer G, Bonhoeffer J, Schaad UB, Heininger U (2007). "Three-year surveillance of intussusception in children in Switzerland". Pediatrics. 120 (3): 473–80. doi:10.1542/peds.2007-0035. PMID 17766518.
  2. Shimabukuro TT, Nguyen M, Martin D, DeStefano F (2015). "Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS)". Vaccine. 33 (36): 4398–405. doi:10.1016/j.vaccine.2015.07.035. PMC 4632204. PMID 26209838.
  3. Bines JE, Liem NT, Justice FA, Son TN, Kirkwood CD, de Campo M, Barnett P, Bishop RF, Robins-Browne R, Carlin JB (2006). "Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus". J. Pediatr. 149 (4): 452–60. doi:10.1016/j.jpeds.2006.04.010. PMID 17011313.
  4. Ebert EC (2008). "Gastrointestinal manifestations of Henoch-Schonlein Purpura". Dig. Dis. Sci. 53 (8): 2011–9. doi:10.1007/s10620-007-0147-0. PMID 18351468.
  5. Cohen DM, Conard FU, Treem WR, Hyams JS (1992). "Jejunojejunal intussusception in Crohn's disease". J. Pediatr. Gastroenterol. Nutr. 14 (1): 101–3. PMID 1573498.
  6. López-Tomassetti Fernández EM, Lorenzo Rocha N, Arteaga González I, Carrillo Pallarés A (2006). "Ileoileal intussusception as initial manifestation of Crohn's disease". Mcgill J Med. 9 (1): 34–7. PMC 2687895. PMID 19529808.
  7. "Thieme E-Journals - Clinics in Colon and Rectal Surgery / Abstract".

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