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{{cholangiocarcinoma}}
{{cholangiocarcinoma}}
{{CMG}};{{AE}} {{PSK}}
{{CMG}}; {{AE}}{{F.K}} [mailto:fkahe@bidmc.harvard.edu], {{PSK}}
==Overview==
==Overview==
Cholangiocarcinoma may be classified according to location of the tumor into three subtypes of [[intrahepatic bile ducts|Intrahepatic bile duct]] cancer, perihilar bile duct cancer, and extrahepatic bile duct cancer.
==Classification==
==Classification==
Cholangiocarcinoma may be classified according to location of the tumor into 3 subtypes:
*Cholangiocarcinoma may be classified according to location of the tumor into three subtypes:<ref name="pmid17457168">{{cite journal |vauthors=DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD |title=Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution |journal=Ann. Surg. |volume=245 |issue=5 |pages=755–62 |year=2007 |pmid=17457168 |pmc=1877058 |doi=10.1097/01.sla.0000251366.62632.d3 |url=}}</ref><ref name="pmid25181580">{{cite journal |vauthors=Aishima S, Oda Y |title=Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type |journal=J Hepatobiliary Pancreat Sci |volume=22 |issue=2 |pages=94–100 |year=2015 |pmid=25181580 |doi=10.1002/jhbp.154 |url=}}</ref><ref name="pmid28271275">{{cite journal |vauthors=Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG, Ganesan K |title=Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management |journal=Abdom Radiol (NY) |volume=42 |issue=6 |pages=1637–1649 |year=2017 |pmid=28271275 |doi=10.1007/s00261-017-1094-7 |url=}}</ref>
*Extrahepatic Bile Duct Cancer
**[[Intrahepatic bile ducts|Intrahepatic bile duct]] cancer
*Perihilar Bile Duct Cancer
**Perihilar [[bile duct]] cancer
*Intrahepatic Bile Duct Cancer
**[[Extrahepatic bile ducts|Extrahepatic bile duct]] cancer
===Cellular Classification of Cholangiocarcinoma===
===Cellular Classification of Cholangiocarcinoma===
'''Extrahepatic Bile Duct Cancer'''
'''Intrahepatic Bile Duct Cancer'''
Adenocarcinomas are the most common type of extrahepatic bile duct tumors. The histologic subtypes include:
*Mass-forming tumor growth pattern
*Carcinoma in situ
*Periductal-infiltrating tumor growth pattern
*Adenocarcinoma, not otherwise specified (NOS)
*Mixed mass-forming and periductal-infiltrating growth pattern
*Adenocarcinoma, intestinal type
 
*Mucinous adenocarcinoma
'''Perihilar Bile Duct Cancer'''
*Clear cell adenocarcinoma
*[[Carcinoma]] in situ
*Adenocarcinoma
:*[[Intestinal]] type
:*[[Mucinous]] type
:*[[Clear cell tumor|Clear cell]] type
*Signet-ring cell carcinoma
*Signet-ring cell carcinoma
*Adenosquamous carcinoma
*Adenosquamous carcinoma
*Squamous cell carcinoma
*[[Squamous cell]] carcinoma
*Small cell (oat cell) carcinoma
*[[Small cell]] (oat cell) carcinoma
*Undifferentiated carcinoma
*Undifferentiated carcinoma
:*Spindle and giant cell types
:*[[Spindle cells|Spindle cell]] type
:*Small cell types
:*[[Giant cell]] type
*Papillomatosis
:*[[Small cell]] type
*Papillary carcinoma, noninvasive
*[[Papillomatosis]]
*Papillary carcinoma, invasive
*Papillary carcinoma
:*[[Noninvasive]]
:*[[Invasive]]
*Carcinoma, NOS
*Carcinoma, NOS


'''Perihilar Bile Duct Cancer'''
'''Extrahepatic Bile Duct Cancer'''
Adenocarcinomas are the most common type of perihilar bile duct tumors. The histologic types include the following:
*Carcinoma in situ
 
*[[Adenocarcinoma]], not otherwise specified (NOS)
Carcinoma in situ.
*Adenocarcinoma
Adenocarcinoma, not otherwise specified (NOS).
:*[[Intestinal]] type
Adenocarcinoma, intestinal type.
:*Mucinous type
Mucinous adenocarcinoma.
:*Clear cell type
Clear cell adenocarcinoma.
*Signet-ring cell carcinoma
Signet-ring cell carcinoma.
*[[Adenosquamous carcinoma]]
Adenosquamous carcinoma.
*[[Squamous cell carcinoma]]
Squamous cell carcinoma.
*[[Small cell]] (oat cell) carcinoma
Small cell (oat cell) carcinoma.
*Undifferentiated carcinoma
Undifferentiated carcinoma
:*[[Spindle cell]] type
 
:*[[Giant cell]] type
Spindle and giant cell types.
:*[[Small cell]] type
Small cell types.
*[[Papillomatosis]]
 
*Papillary carcinoma
Papillomatosis.
:*Noninvasive
Papillary carcinoma, noninvasive.
*Papillary carcinoma
Papillary carcinoma, invasive.
**[[Invasive]]
Carcinoma, NOS
 
Intrahepatic Bile Duct Cancer
The most common histologic types of intrahepatic bile duct tumors include the following:
 
Intrahepatic cholangiocarcinoma.


Mass-forming tumor growth pattern.
Periductal-infiltrating tumor growth pattern.
Mixed mass-forming and periductal-infiltrating growth pattern.


Mixed hepatocellular.
'''Bismuth-Corlette classification'''
*'''Type I:''' [[Tumor|Tumors]] are distal to the hepatic duct confluence 
*'''Type II:''' Neoplasms extend to and involve the hepatic duct confluence
*'''Type IIIA:''' Tumors involve the hepatic duct confluence and either the proximal right hepatic duct
*'''Type IIIB:''' Tumors involve the hepatic duct confluence and either the proximal left hepatic duct
*'''Type IV:''' Tumors extend into the [[bilateral]] proximal hepatic ducts up to the segmental [[Bile duct|bile ducts]]


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 14:44, 12 February 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] [3], Suveenkrishna Pothuru, M.B,B.S. [4]

Overview

Cholangiocarcinoma may be classified according to location of the tumor into three subtypes of Intrahepatic bile duct cancer, perihilar bile duct cancer, and extrahepatic bile duct cancer.

Classification

Cellular Classification of Cholangiocarcinoma

Intrahepatic Bile Duct Cancer

  • Mass-forming tumor growth pattern
  • Periductal-infiltrating tumor growth pattern
  • Mixed mass-forming and periductal-infiltrating growth pattern

Perihilar Bile Duct Cancer

  • Signet-ring cell carcinoma
  • Adenosquamous carcinoma
  • Squamous cell carcinoma
  • Small cell (oat cell) carcinoma
  • Undifferentiated carcinoma
  • Carcinoma, NOS

Extrahepatic Bile Duct Cancer

  • Carcinoma in situ
  • Adenocarcinoma, not otherwise specified (NOS)
  • Adenocarcinoma
  • Noninvasive


Bismuth-Corlette classification

  • Type I: Tumors are distal to the hepatic duct confluence
  • Type II: Neoplasms extend to and involve the hepatic duct confluence
  • Type IIIA: Tumors involve the hepatic duct confluence and either the proximal right hepatic duct
  • Type IIIB: Tumors involve the hepatic duct confluence and either the proximal left hepatic duct
  • Type IV: Tumors extend into the bilateral proximal hepatic ducts up to the segmental bile ducts

References

  1. ↑ DeOliveira ML, Cunningham SC, Cameron JL, Kamangar F, Winter JM, Lillemoe KD, Choti MA, Yeo CJ, Schulick RD (2007). "Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution". Ann. Surg. 245 (5): 755–62. doi:10.1097/01.sla.0000251366.62632.d3. PMC 1877058. PMID 17457168.
  2. ↑ Aishima S, Oda Y (2015). "Pathogenesis and classification of intrahepatic cholangiocarcinoma: different characters of perihilar large duct type versus peripheral small duct type". J Hepatobiliary Pancreat Sci. 22 (2): 94–100. doi:10.1002/jhbp.154. PMID 25181580.
  3. ↑ Oliveira IS, Kilcoyne A, Everett JM, Mino-Kenudson M, Harisinghani MG, Ganesan K (2017). "Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management". Abdom Radiol (NY). 42 (6): 1637–1649. doi:10.1007/s00261-017-1094-7. PMID 28271275.
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