Focal segmental glomerulosclerosis causes: Difference between revisions

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__NOTOC__
__NOTOC__
{{Focal segmental glomerulosclerosis}}
{{Focal segmental glomerulosclerosis}}
{{CMG}}{{APM}}; '''Associate Editor-In-Chief:’’’{{OO}} {{CZ}}
{{CMG}} {{AE}} {{MKK}}
==Overview==
 
 
===Common Causes===
[Disease name] may be caused by:
*[Cause1]
*[Cause2]
*[Cause3
 
 
*[Disease name] is caused by an infection with [pathogen name].
*[Pathogen name] is caused by [pathogen name].


==Overview==
===Less Common Causes===
Less common causes of [[disease name]] include:
*[Cause1]
*[Cause2]
*[Cause3]


==Causes==
===Genetic Causes===
According to D'Agati and colleagues,<ref name="pmid12704572">{{cite journal| author=D'Agati V| title=Pathologic classification of focal segmental glomerulosclerosis. | journal=Semin Nephrol | year= 2003 | volume= 23 | issue= 2 | pages= 117-34 | pmid=12704572 | doi=10.1053/snep.2003.50012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704572  }} </ref> FSGS may be primary of secondary. Primary FSGS is defined as idiopathic FSGS, whereas secondary FSGS is defined as FSGS other etiologies.<ref name="pmid12704572">{{cite journal| author=D'Agati V| title=Pathologic classification of focal segmental glomerulosclerosis. | journal=Semin Nephrol | year= 2003 | volume= 23 | issue= 2 | pages= 117-34 | pmid=12704572 | doi=10.1053/snep.2003.50012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12704572  }} </ref>
The following list shows all the causes of FSGS<ref name="pmid23871408">{{cite journal| author=Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH et al.| title=KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis. | journal=Am J Kidney Dis | year= 2013 | volume= 62 | issue= 3 | pages= 403-41 | pmid=23871408 | doi=10.1053/j.ajkd.2013.06.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23871408  }} </ref>:
===Primary (Idiopathic) FSGS===
===Secondary FSGS===
====Familial====
*Mutations in [[alpha actinin 4]]
*Mutations in [[alpha actinin 4]]
*Mutations in NPHS1 ([[nephrin]])
*Mutations in NPHS1 ([[nephrin]])
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*[[Anabolic steroids]]
*[[Anabolic steroids]]


====Adaptive Structural-Functional Responses====
=
=====Reduced Kidney Size=====
 
*Oligomeganephronia
*Unilateral kidney agenesis
*Kidney dysplasia
*Cortical necrosis
*[[Reflux nephropathy]]
*Surgical kidney ablation
*Chronic allograft nephropathy
*Any advanced kidney disease with reduction in functioning [[nephrons]]


=====Initially Normal Kidney Mass=====
*[[Diabetes mellitus]]
*[[Diabetes mellitus]]
*[[Hypertension]]
*[[Hypertension]]
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====Malignancy====
====Malignancy====
*[[Lymphoma]]
*[[Lymphoma]]
====Nonspecific Pattern of FSGS Caused by Kidney Scarring in Glomerular Disease====
*Focal proliferative [[glomerulonephritis]]
**[[IgA nephropathy]]
**[[Lupus nephritis]]
**Pauci-immune focal necrotizing and [[crescentic glomerulonephritis]]
*[[Alport's syndrome]] (hereditary nephritis)
*[[Membranous nephropathy]]
*[[Thrombotic microangiopathy]]


==References==
==References==

Latest revision as of 17:04, 1 June 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

Common Causes

[Disease name] may be caused by:

  • [Cause1]
  • [Cause2]
  • [Cause3


  • [Disease name] is caused by an infection with [pathogen name].
  • [Pathogen name] is caused by [pathogen name].

Less Common Causes

Less common causes of disease name include:

  • [Cause1]
  • [Cause2]
  • [Cause3]

Genetic Causes

Virus Associated

Medication

=


Malignancy

References


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