Focal segmental glomerulosclerosis history and symptoms: Difference between revisions
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The hallmark of focal segmental glomerulosclerosis is nephrotic-range proteinuria.<ref name="pmid7702047">{{cite journal| author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047}} </ref> | The hallmark of focal segmental glomerulosclerosis is nephrotic-range proteinuria.<ref name="pmid7702047">{{cite journal| author=Rydel JJ, Korbet SM, Borok RZ, Schwartz MM| title=Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment. | journal=Am J Kidney Dis | year= 1995 | volume= 25 | issue= 4 | pages= 534-42 | pmid=7702047 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7702047}} </ref> | ||
===History=== | ===History=== | ||
Patients with focal segmental glomerulosclerosis may have a positive history of: | Patients with focal segmental glomerulosclerosis may have a positive history of:<ref name="pmid22187987">{{cite journal |vauthors=D'Agati VD, Kaskel FJ, Falk RJ |title=Focal segmental glomerulosclerosis |journal=N. Engl. J. Med. |volume=365 |issue=25 |pages=2398–411 |date=December 2011 |pmid=22187987 |doi=10.1056/NEJMra1106556 |url=}}</ref><ref name="pmid16761013">{{cite journal |vauthors=Dijkman HB, Weening JJ, Smeets B, Verrijp KC, van Kuppevelt TH, Assmann KK, Steenbergen EJ, Wetzels JF |title=Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells |journal=Kidney Int. |volume=70 |issue=2 |pages=338–44 |date=July 2006 |pmid=16761013 |doi=10.1038/sj.ki.5001574 |url=}}</ref><ref name="pmid20203164">{{cite journal |vauthors=Markowitz GS, Nasr SH, Stokes MB, D'Agati VD |title=Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosis |journal=Clin J Am Soc Nephrol |volume=5 |issue=4 |pages=607–15 |date=April 2010 |pmid=20203164 |pmc=2849683 |doi=10.2215/CJN.07311009 |url=}}</ref> | ||
*Positive family history of FSGN | *Positive family history of FSGN | ||
*Heroin abuse | *Heroin abuse | ||
*Chronic viral infections such as hepatitis B | *Chronic viral infections such as hepatitis B | ||
*Medications such as bisphosphonates | *Medications such as bisphosphonates, sunitinib, and interferon | ||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of focal segmental glomerulosclerosis include:<ref name="pmid16939521">{{cite journal |vauthors=Choy BY, Chan TM, Lai KN |title=Recurrent glomerulonephritis after kidney transplantation |journal=Am. J. Transplant. |volume=6 |issue=11 |pages=2535–42 |date=November 2006 |pmid=16939521 |doi=10.1111/j.1600-6143.2006.01502.x |url=}}</ref> | Common symptoms of focal segmental glomerulosclerosis include:<ref name="pmid16939521">{{cite journal |vauthors=Choy BY, Chan TM, Lai KN |title=Recurrent glomerulonephritis after kidney transplantation |journal=Am. J. Transplant. |volume=6 |issue=11 |pages=2535–42 |date=November 2006 |pmid=16939521 |doi=10.1111/j.1600-6143.2006.01502.x |url=}}</ref><ref name="pmid12453201">{{cite journal |vauthors=Baum MA, Ho M, Stablein D, Alexander SR |title=Outcome of renal transplantation in adolescents with focal segmental glomerulosclerosis |journal=Pediatr Transplant |volume=6 |issue=6 |pages=488–92 |date=December 2002 |pmid=12453201 |doi= |url=}}</ref> | ||
*Proteinuria | *Proteinuria | ||
*Hematuria | *Hematuria | ||
| Line 21: | Line 21: | ||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of | Less common symptoms of focal segmental glomerulosclerosis include | ||
*Fatigue | *Fatigue | ||
*Malaise | *Malaise | ||
* | *Symptoms of chronic renal failure such as anuria, edema | ||
==References== | ==References== | ||
Latest revision as of 14:05, 11 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
History and Symptoms
The hallmark of focal segmental glomerulosclerosis is nephrotic-range proteinuria.[1]
History
Patients with focal segmental glomerulosclerosis may have a positive history of:[2][3][4]
- Positive family history of FSGN
- Heroin abuse
- Chronic viral infections such as hepatitis B
- Medications such as bisphosphonates, sunitinib, and interferon
Common Symptoms
Common symptoms of focal segmental glomerulosclerosis include:[5][6]
- Proteinuria
- Hematuria
- Anasarca
- Headache and blurry vision which is suggestive of high blood pressure
Less Common Symptoms
Less common symptoms of focal segmental glomerulosclerosis include
- Fatigue
- Malaise
- Symptoms of chronic renal failure such as anuria, edema
References
- ↑ Rydel JJ, Korbet SM, Borok RZ, Schwartz MM (1995). "Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment". Am J Kidney Dis. 25 (4): 534–42. PMID 7702047.
- ↑ D'Agati VD, Kaskel FJ, Falk RJ (December 2011). "Focal segmental glomerulosclerosis". N. Engl. J. Med. 365 (25): 2398–411. doi:10.1056/NEJMra1106556. PMID 22187987.
- ↑ Dijkman HB, Weening JJ, Smeets B, Verrijp KC, van Kuppevelt TH, Assmann KK, Steenbergen EJ, Wetzels JF (July 2006). "Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells". Kidney Int. 70 (2): 338–44. doi:10.1038/sj.ki.5001574. PMID 16761013.
- ↑ {{cite journal |vauthors=Markowitz GS, Nasr SH, Stokes MB, D'Agati VD |title=Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosis |journal=Clin J Am Soc Nephrol |volume=5 |issue=4 |pages=607–15 |date=April 2010 |pmid=20203164 |pmc=2849683 |doi=10.2215/CJN.07311009 |url=}}
- ↑ Choy BY, Chan TM, Lai KN (November 2006). "Recurrent glomerulonephritis after kidney transplantation". Am. J. Transplant. 6 (11): 2535–42. doi:10.1111/j.1600-6143.2006.01502.x. PMID 16939521.
- ↑ Baum MA, Ho M, Stablein D, Alexander SR (December 2002). "Outcome of renal transplantation in adolescents with focal segmental glomerulosclerosis". Pediatr Transplant. 6 (6): 488–92. PMID 12453201.