Focal segmental glomerulosclerosis other diagnostic studies: Difference between revisions
Jump to navigation
Jump to search
(Created page with "__NOTOC__ {{Focal segmental glomerulosclerosis}} {{CMG}}; '''Associate Editor-In-Chief:’’’ {{CZ}} Please help WikiDoc by adding more content here. It's easy! Click [...") |
No edit summary |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Focal segmental glomerulosclerosis}} | {{Focal segmental glomerulosclerosis}} | ||
{{CMG}}; '''Associate Editor-In-Chief:’’’ {{CZ}} | {{CMG}}; '''Associate Editor-In-Chief:’’’ {{MKK}} {{CZ}} | ||
==Overview== | ==Overview== | ||
== | ==Renal Biopsy== | ||
A kidney biopsy with electron microscopy is recommended for all patients with FSGS for prognostic and therapeutic purposes. The following table shows the pathological classification of FSGS based on characteristic features. Electron microscopy generally shows podocyte foot process effacement. | |||
Based on the proposed Columbia classification by D’Agati and colleagues<ref name="pmid14750104">{{cite journal| author=D'Agati VD, Fogo AB, Bruijn JA, Jennette JC| title=Pathologic classification of focal segmental glomerulosclerosis: a working proposal. | journal=Am J Kidney Dis | year= 2004| volume= 43 | issue= 2 | pages= 368-82 | pmid=14750104 | doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14750104 }} </ref> in 2004, the classification of focal segmental glomerulosclerosis (FSGS) based on the morphology is as follows: | |||
{| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center" | |||
|+ '''''Pathological Classification of Focal Segmental Glomerulosclerosis<ref name="pmid14750104">{{cite journal| author=D'Agati VD, Fogo AB, Bruijn JA, Jennette JC|title=Pathologic classification of focal segmental glomerulosclerosis: a working proposal. |journal=Am J Kidney Dis | year= 2004 |volume= 43 | issue= 2 | pages= 368-82 | pmid=14750104 |doi= | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14750104 }} </ref>''''' | |||
| bgcolor="#d9ff54"|'''Variant''' || bgcolor="#d9ff54"|'''Location of Lesion'''||bgcolor="#d9ff54"|'''Distribution of Lesion'''|| bgcolor="#d9ff54"|'''Characteristic Features''' | |||
|- | |||
| bgcolor="#ececec"|'''Not Otherwise Specified (NOS)''' || Anywhere|| Segmental|| Capillary lumen abolished by the segmental increase in matrix. | |||
|- | |||
| bgcolor="#ececec"|'''Perihilar Variant''' || Perihilar||Segmental|| Presence of one or more glomeruli containing hyalinosis in the perihilar regions with or without sclerosis. Within each glomerulus, the segmental lesions must contain > 50% perihilar hyalinosis and/or sclerosis. | |||
|- | |||
| bgcolor="#ececec"|'''Cellular Variant''' || Anywhere|| Segmental|| Presence of one or more glomerulus with segmental hypercellularity of the capillary endothelium that blocks the capillary lumen, with or without foam cells and/or karryohexis. | |||
|- | |||
| bgcolor="#ececec"|'''Tip Variant''' || At tip domain|| Segmental|| One or more segmental lesions, that include tip domains. Lesions must have adhesions/confluence of podocytes with parietal or tubular cells. Tip domains are defined as 25% of tuft adjacent to the origin of the proximal tubule. Sclerosing lesions shuld be <25% of tuft, while cellular lesions should be < 50% of tuft. No perihilar sclerosis should be observed. | |||
|- | |||
|bgcolor="#ececec"|'''Collapsing Variant''' || Anywhere|| Segmental or global|| One or more glomeruli with collapse with evidence of podocyte hypertrophy and hyperplasia. | |||
|} | |||
<sup><center>Adapted from D’Agati VD, Fogo AB, Bruijn JA, and Jennette JC. Pathological classification of focal segmental glomerulosclerosis. A working proposal. ''Am J of Kidney Dis''. 2004; 43(2):368-382.</center></sup> | |||
==References== | ==References== | ||
Latest revision as of 19:56, 11 June 2018
|
Focal segmental glomerulosclerosis Microchapters |
|
Differentiating Focal segmental glomerulosclerosis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Focal segmental glomerulosclerosis other diagnostic studies On the Web |
|
American Roentgen Ray Society Images of Focal segmental glomerulosclerosis other diagnostic studies |
|
FDA on Focal segmental glomerulosclerosis other diagnostic studies |
|
CDC on Focal segmental glomerulosclerosis other diagnostic studies |
|
Focal segmental glomerulosclerosis other diagnostic studies in the news |
|
Blogs on Focal segmental glomerulosclerosis other diagnostic studies |
|
Directions to Hospitals Treating Focal segmental glomerulosclerosis |
|
Risk calculators and risk factors for Focal segmental glomerulosclerosis other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief:’’’ Manpreet Kaur, MD [2] Cafer Zorkun, M.D., Ph.D. [3]
Overview
Renal Biopsy
A kidney biopsy with electron microscopy is recommended for all patients with FSGS for prognostic and therapeutic purposes. The following table shows the pathological classification of FSGS based on characteristic features. Electron microscopy generally shows podocyte foot process effacement.
Based on the proposed Columbia classification by D’Agati and colleagues[1] in 2004, the classification of focal segmental glomerulosclerosis (FSGS) based on the morphology is as follows:
| Variant | Location of Lesion | Distribution of Lesion | Characteristic Features |
| Not Otherwise Specified (NOS) | Anywhere | Segmental | Capillary lumen abolished by the segmental increase in matrix. |
| Perihilar Variant | Perihilar | Segmental | Presence of one or more glomeruli containing hyalinosis in the perihilar regions with or without sclerosis. Within each glomerulus, the segmental lesions must contain > 50% perihilar hyalinosis and/or sclerosis. |
| Cellular Variant | Anywhere | Segmental | Presence of one or more glomerulus with segmental hypercellularity of the capillary endothelium that blocks the capillary lumen, with or without foam cells and/or karryohexis. |
| Tip Variant | At tip domain | Segmental | One or more segmental lesions, that include tip domains. Lesions must have adhesions/confluence of podocytes with parietal or tubular cells. Tip domains are defined as 25% of tuft adjacent to the origin of the proximal tubule. Sclerosing lesions shuld be <25% of tuft, while cellular lesions should be < 50% of tuft. No perihilar sclerosis should be observed. |
| Collapsing Variant | Anywhere | Segmental or global | One or more glomeruli with collapse with evidence of podocyte hypertrophy and hyperplasia. |
References
- ↑ 1.0 1.1 D'Agati VD, Fogo AB, Bruijn JA, Jennette JC (2004). "Pathologic classification of focal segmental glomerulosclerosis: a working proposal". Am J Kidney Dis. 43 (2): 368–82. PMID 14750104.