Ankylosing spondylitis risk factors: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(10 intermediate revisions by 5 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Ankylosing spondylitis}}
{{Ankylosing spondylitis}}
{{CMG}}
{{CMG}} ; {{AE}} {{MKK}}


==Overview==
==Overview==
Patients with [[HLA-B27]] variant are at highest risk of developing ankylosing spondylitis.
There is no known cause specific [[Causes|cause]] for [[ankylosing spondylitis]], though genetic factors seems to play very important role in developing the [[disease]]. In particular, people who are positive for HLA-B27 are at more risk of developing [[ankylosing spondylitis]].[[Ankylosing spondylitis]] is a form of [[chronic]] [[joint]] [[inflammation]] that mostly affects the [[spine]]. Gradually it can cause the bones of the spine to fuse together, a process which is called [[ankylosis]].
 
==Risk Factors==
==Risk Factors==
Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the [[HLA-B27]] variant are at highest risk of developing the disorder. HLA-B27, demonstrated in a [[blood test]], is occasionally used as a diagnostic, but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries).
*There is no known cause specific cause for [[ankylosing spondylitis]], though [[Genetics|genetic]] factors seem to play a very important role in developing the disease. In particular, people who are positive for HLA-B27 are at more risk of developing ankylosing spondylitis.Ankylosing spondylitis is a form of chronic joint [[inflammation]] that mostly affects the [[spine]]. Gradually it can cause the bones of the spine to fuse together, a process which is called [[ankylosis]].<ref name="pmid23841117">{{cite journal |vauthors=Reveille JD, Weisman MH |title=The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States |journal=Am. J. Med. Sci. |volume=345 |issue=6 |pages=431–6 |date=June 2013 |pmid=23841117 |pmc=4122314 |doi= |url=}}</ref>
*The most potent risk factor in the development of [[ankylosing spondylitis]] is positive for [[HLA-B27|HLA-B2]]7. Other risk factors include environmental, gender, and [[age]].<ref name="pmid21358307">{{cite journal |vauthors=Dillon CF, Hirsch R |title=The United States National Health and Nutrition Examination Survey and the epidemiology of ankylosing spondylitis |journal=Am. J. Med. Sci. |volume=341 |issue=4 |pages=281–3 |date=April 2011 |pmid=21358307 |doi=10.1097/MAJ.0b013e31820f8c83 |url=}}</ref>


==References==
==References==

Latest revision as of 03:09, 30 July 2018

Ankylosing spondylitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Ankylosing spondylitis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ankylosing spondylitis risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ankylosing spondylitis risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ankylosing spondylitis risk factors

CDC on Ankylosing spondylitis risk factors

Ankylosing spondylitis risk factors in the news

Blogs on Ankylosing spondylitis risk factors

Directions to Hospitals Treating Ankylosing spondylitis

Risk calculators and risk factors for Ankylosing spondylitis risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]

Overview

There is no known cause specific cause for ankylosing spondylitis, though genetic factors seems to play very important role in developing the disease. In particular, people who are positive for HLA-B27 are at more risk of developing ankylosing spondylitis.Ankylosing spondylitis is a form of chronic joint inflammation that mostly affects the spine. Gradually it can cause the bones of the spine to fuse together, a process which is called ankylosis.

Risk Factors

  • There is no known cause specific cause for ankylosing spondylitis, though genetic factors seem to play a very important role in developing the disease. In particular, people who are positive for HLA-B27 are at more risk of developing ankylosing spondylitis.Ankylosing spondylitis is a form of chronic joint inflammation that mostly affects the spine. Gradually it can cause the bones of the spine to fuse together, a process which is called ankylosis.[1]
  • The most potent risk factor in the development of ankylosing spondylitis is positive for HLA-B27. Other risk factors include environmental, gender, and age.[2]

References

  1. Reveille JD, Weisman MH (June 2013). "The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States". Am. J. Med. Sci. 345 (6): 431–6. PMC 4122314. PMID 23841117.
  2. Dillon CF, Hirsch R (April 2011). "The United States National Health and Nutrition Examination Survey and the epidemiology of ankylosing spondylitis". Am. J. Med. Sci. 341 (4): 281–3. doi:10.1097/MAJ.0b013e31820f8c83. PMID 21358307.

Template:WH Template:WS