Membranoproliferative glomerulonephritis medical therapy: Difference between revisions

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== Overview ==
== Overview ==
The treatment of membranoproliferative glomerulonephritis depends on the cause of the disease.In [[Infection|infectious]] and haematological etiology treating the underlying infection will result in resolution of membranoproliferative glomerulonephritis.For [[Autoimmunity|autoimmune]] etiology [[Immunosuppression|immunosuppressive]] agents are given.The treatment also includes [[antihypertensive]] therapy, [[Anticoagulant|anticoagulation therapy]] and  [[Statins|anti-lipid]] therapy for [[Nephrotic syndrome|nephrotic syndrome.]]
The optimal therapy for membranoproliferative glomerulonephritis depends on underlying etiology. In [[Infection|infectious]] and haematological etiology treating the underlying infection will result in resolution of membranoproliferative glomerulonephritis.For [[Autoimmunity|autoimmune]] etiology [[Immunosuppression|immunosuppressive]] agents are given.The treatment also includes [[antihypertensive]] therapy, [[Anticoagulant|anticoagulation therapy]] and  [[Statins|anti-lipid]] therapy for [[Nephrotic syndrome|nephrotic syndrome.]]


== Medical Therapy ==
== Medical Therapy ==
* Pharmacologic therapy is recommended for patients of membranoproliferative glomerulonephritis.<ref name="pmid29852477">{{cite journal| author=Bomback AS, Fervenza FC| title=Membranous Nephropathy: Approaches to Treatment. | journal=Am J Nephrol | year= 2018 | volume= 47 Suppl 1 | issue=  | pages= 30-42 | pmid=29852477 | doi=10.1159/000481635 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29852477  }}</ref>><ref name="pmid22859855">{{cite journal| author=Waldman M, Austin HA| title=Treatment of idiopathic membranous nephropathy. | journal=J Am Soc Nephrol | year= 2012 | volume= 23 | issue= 10 | pages= 1617-30 | pmid=22859855 | doi=10.1681/ASN.2012010058 | pmc=3458460 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22859855  }}</ref><ref name="pmid10495797">{{cite journal |vauthors=Wasserstein AG |title=Membranous glomerulonephritis |journal=J. Am. Soc. Nephrol. |volume=8 |issue=4 |pages=664–74 |date=April 1997 |pmid=10495797 |doi= |url=}}</ref><ref name="pmid15847250">{{cite journal |vauthors=Ozsoy RC, Koopman MG, Kastelein JJ, Arisz L |title=The acute effect of atorvastatin on proteinuria in patients with chronic glomerulonephritis |journal=Clin. Nephrol. |volume=63 |issue=4 |pages=245–9 |date=April 2005 |pmid=15847250 |doi= |url=}}</ref>
* Pharmacologic therapy is recommended for patients of membranoproliferative glomerulonephritis.  Treatment options depends upon underlying etiology.<ref name="pmid29852477">{{cite journal| author=Bomback AS, Fervenza FC| title=Membranous Nephropathy: Approaches to Treatment. | journal=Am J Nephrol | year= 2018 | volume= 47 Suppl 1 | issue=  | pages= 30-42 | pmid=29852477 | doi=10.1159/000481635 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29852477  }}</ref><ref name="pmid22859855">{{cite journal| author=Waldman M, Austin HA| title=Treatment of idiopathic membranous nephropathy. | journal=J Am Soc Nephrol | year= 2012 | volume= 23 | issue= 10 | pages= 1617-30 | pmid=22859855 | doi=10.1681/ASN.2012010058 | pmc=3458460 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22859855  }}</ref><ref name="pmid10495797">{{cite journal |vauthors=Wasserstein AG |title=Membranous glomerulonephritis |journal=J. Am. Soc. Nephrol. |volume=8 |issue=4 |pages=664–74 |date=April 1997 |pmid=10495797 |doi= |url=}}</ref><ref name="pmid15847250">{{cite journal |vauthors=Ozsoy RC, Koopman MG, Kastelein JJ, Arisz L |title=The acute effect of atorvastatin on proteinuria in patients with chronic glomerulonephritis |journal=Clin. Nephrol. |volume=63 |issue=4 |pages=245–9 |date=April 2005 |pmid=15847250 |doi= |url=}}</ref>
.
* Patients with autoimmune etiology are treated with [[immunosuppressive]] therapy.
* The treatment depends on the cause of the disease.
* Patients with infectious etiology are treated with antivirals or [[Antibiotic|antibiotics]] .
* Patients with [[Autoimmune|autoimmuneetiology]]  are treated with [[immunosuppressive]] therapy
* Patients with infectious etiology are treated with antivirals or [[Antibiotic|antibiotics]] depending on the cause.
* [[Hepatitis B]] and [[Hepatitis C]] are treated with antivirals.
* [[Hepatitis B]] and [[Hepatitis C]] are treated with antivirals.
** [[Leukemia|Leukemias]] and [[Lymphoma|lymphomas]] treated with [[chemotherapy]].
** [[Leukemia|Leukemias]] and [[Lymphoma|lymphomas]] treated with [[chemotherapy]].

Latest revision as of 20:52, 2 August 2018


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3] Jogeet Singh Sekhon, M.D. [4] Syed Ahsan Hussain, M.D.[5]

Overview

The optimal therapy for membranoproliferative glomerulonephritis depends on underlying etiology. In infectious and haematological etiology treating the underlying infection will result in resolution of membranoproliferative glomerulonephritis.For autoimmune etiology immunosuppressive agents are given.The treatment also includes antihypertensive therapy, anticoagulation therapy and anti-lipid therapy for nephrotic syndrome.

Medical Therapy

  • Pharmacologic therapy is recommended for patients of membranoproliferative glomerulonephritis. Treatment options depends upon underlying etiology.[1][2][3][4]
  • Patients with autoimmune etiology are treated with immunosuppressive therapy.
  • Patients with infectious etiology are treated with antivirals or antibiotics .
  • Hepatitis B and Hepatitis C are treated with antivirals.
  • Other pharmacologic medical therapies for membranoproliferative glomerulonephritis include antihypertensive therapy, anticoagulation therapy and anti-lipid therapy.

1. Patients with autoimmune etiology

  • 1.1 Immunosuppressive therapy:
  • 2. Treatment for nephrotic sydnrome:

References

  1. Bomback AS, Fervenza FC (2018). "Membranous Nephropathy: Approaches to Treatment". Am J Nephrol. 47 Suppl 1: 30–42. doi:10.1159/000481635. PMID 29852477.
  2. Waldman M, Austin HA (2012). "Treatment of idiopathic membranous nephropathy". J Am Soc Nephrol. 23 (10): 1617–30. doi:10.1681/ASN.2012010058. PMC 3458460. PMID 22859855.
  3. Wasserstein AG (April 1997). "Membranous glomerulonephritis". J. Am. Soc. Nephrol. 8 (4): 664–74. PMID 10495797.
  4. Ozsoy RC, Koopman MG, Kastelein JJ, Arisz L (April 2005). "The acute effect of atorvastatin on proteinuria in patients with chronic glomerulonephritis". Clin. Nephrol. 63 (4): 245–9. PMID 15847250.

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