Membranoproliferative glomerulonephritis historical perspective: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(5 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Membranoproliferative glomerulonephritis}}
{{Membranoproliferative glomerulonephritis}}
{{CMG}] ; {{AE}}
{{CMG}} ; {{AE}}


==Overview==
==Overview==
The term membranous glomerulonephritis was used first by Bell in 1946 to describe a category of [[glomerular]] renal disease classified within the spectrum of Ellis type II glomerulonephritis. This category also included [[lipoid nephrosis]], lobular glomerulonephritis, and chronic glomerulonephritis. In 1957, David Jones, a renal pathologist from Syracuse University in New York, separated membranous glomerulonephritis as a distinct morphologic entity. Jones fully illustrated the special features of this lesion such as lobular glomerulonephritis, lipoid nephrosis and chronic glomerulonephritis. Thickening of the capillary wall and alteration in [[basement membrane]] structure were described. Electron-dense subepithelial locations were identified by Movat and McGregor in 1959 using electron microscopic methods. Mellors  in 1957 identified the unique lesion of membranous glomerulonephritis, the presence of immunoglobulin in the deposits, using the immunofluorescence technique. Thus, over the span of just 2 years, the triad of essential features of membranous glomerulonephritis were described. These are still the fundamental features used today to identify membranous glomerulonephritis, now called membranoproliferative glomerulonephritis MPGN.


== Historical Prespective ==
== Historical Prespective ==
*The term membranous glomerulonephritis was used first by Bell in 1946 to describe a category of glomerular renal disease classified within the spectrum of Ellis type II glomerulonephritis. This category also included lipoid nephrosis, lobular glomerulonephritis, and chronic glomerulonephritis .
*In 1946, Bell coined the term membranous glomerulonephritis. <ref name="Glassock2010">{{cite journal|last1=Glassock|first1=Richard J.|title=The Pathogenesis of Idiopathic Membranous Nephropathy: A 50-Year Odyssey|journal=American Journal of Kidney Diseases|volume=56|issue=1|year=2010|pages=157–167|issn=02726386|doi=10.1053/j.ajkd.2010.01.008}}</ref>


*In 1957, David Jones, a renal pathologist from Syracuse University in New York, separated membranous glomerulonephritis as a distinct morphologic entity using the special stain periodic acid–silver methenamine (now known as Jones stain). Jones fully illustrated the special features of this lesion such as lobular glomerulonephritis (now known as membranoproliferative glomerulonephritis), lipoid nephrosis (now known as minimal change disease), and chronic glomerulonephritis (now known as focal and segmental glomerulosclerosis). The thickening of the capillary wall and alteration in basement membrane structure, so characteristic of the membranous lesion, were convincingly shown . 
*In 1957, David Jones, a renal pathologist from Syracuse University in New York, described membranous glomerulonephritis as a distinct morphologic entity.
*Prof. Jones was the first to illustrate complete features of MPGN which include:
**Lobular glomerulonephritis
**Lipoid nephrosis  
**Chronic glomerulonephritis  
*He also described the characteristic thickening of the capillary wall and alteration in [[basement membrane]] structure.


*The electron-dense subepithelial location of the were also subsequently identified by Movat and McGregor in 1959 using electron microscopic methods applied to renal biopsy specimens in 1957. Mellors  in 1957 had identified the third component of the unique lesion of membranous glomerulonephritis; namely, the presence of immunoglobulin in the deposits, using the immunofluorescence technique. Thus, over the span of just 2 years, the triad of essential features of membranous glomerulonephritis were delineated. These are still the fundamental features used today to identify membranous glomerulonephritis, now called Membranoproliferative glomerulonephritis.
*In 1959, Movat and McGregor identified electron-dense subepithelial deposits using electron microscope.  
*In 1957, Mellors was the first to identify immunoglobulin deposits as the third component of membranous glomerulonephritis and later described the triad of MPGN.


{{Membranoproliferative glomerulonephritis}}
{{Membranoproliferative glomerulonephritis}}

Latest revision as of 00:58, 3 August 2018

Membranoproliferative glomerulonephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Membranoproliferative glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Membranoproliferative glomerulonephritis historical perspective On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Membranoproliferative glomerulonephritis historical perspective

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Membranoproliferative glomerulonephritis historical perspective

CDC on Membranoproliferative glomerulonephritis historical perspective

Membranoproliferative glomerulonephritis historical perspective in the news

Blogs on Membranoproliferative glomerulonephritis historical perspective

Directions to Hospitals Treating Membranoproliferative glomerulonephritis

Risk calculators and risk factors for Membranoproliferative glomerulonephritis historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief:

Overview

The term membranous glomerulonephritis was used first by Bell in 1946 to describe a category of glomerular renal disease classified within the spectrum of Ellis type II glomerulonephritis. This category also included lipoid nephrosis, lobular glomerulonephritis, and chronic glomerulonephritis. In 1957, David Jones, a renal pathologist from Syracuse University in New York, separated membranous glomerulonephritis as a distinct morphologic entity. Jones fully illustrated the special features of this lesion such as lobular glomerulonephritis, lipoid nephrosis and chronic glomerulonephritis. Thickening of the capillary wall and alteration in basement membrane structure were described. Electron-dense subepithelial locations were identified by Movat and McGregor in 1959 using electron microscopic methods. Mellors  in 1957 identified the unique lesion of membranous glomerulonephritis, the presence of immunoglobulin in the deposits, using the immunofluorescence technique. Thus, over the span of just 2 years, the triad of essential features of membranous glomerulonephritis were described. These are still the fundamental features used today to identify membranous glomerulonephritis, now called membranoproliferative glomerulonephritis MPGN.

Historical Prespective

  • In 1946, Bell coined the term membranous glomerulonephritis. [1]
  • In 1957, David Jones, a renal pathologist from Syracuse University in New York, described membranous glomerulonephritis as a distinct morphologic entity.
  • Prof. Jones was the first to illustrate complete features of MPGN which include:
    • Lobular glomerulonephritis
    • Lipoid nephrosis
    • Chronic glomerulonephritis
  • He also described the characteristic thickening of the capillary wall and alteration in basement membrane structure.
  • In 1959, Movat and McGregor identified electron-dense subepithelial deposits using electron microscope.
  • In 1957, Mellors was the first to identify immunoglobulin deposits as the third component of membranous glomerulonephritis and later described the triad of MPGN.

Membranoproliferative glomerulonephritis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Membranoproliferative glomerulonephritis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Membranoproliferative glomerulonephritis historical perspective On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Membranoproliferative glomerulonephritis historical perspective

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Membranoproliferative glomerulonephritis historical perspective

CDC on Membranoproliferative glomerulonephritis historical perspective

Membranoproliferative glomerulonephritis historical perspective in the news

Blogs on Membranoproliferative glomerulonephritis historical perspective

Directions to Hospitals Treating Membranoproliferative glomerulonephritis

Risk calculators and risk factors for Membranoproliferative glomerulonephritis historical perspective

References

  1. Glassock, Richard J. (2010). "The Pathogenesis of Idiopathic Membranous Nephropathy: A 50-Year Odyssey". American Journal of Kidney Diseases. 56 (1): 157–167. doi:10.1053/j.ajkd.2010.01.008. ISSN 0272-6386.

Template:WH Template:WS