Membranoproliferative glomerulonephritis diagnostic study of choice: Difference between revisions
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{{Membranoproliferative glomerulonephritis}} | |||
{{CMG}} ; {{AE}} {{JSS}} {{SAH}} | |||
==Overview== | ==Overview== | ||
Renal biopsy is considered the gold standard diagnostic test for MPGN. | |||
== Diagnostic study of choice == | |||
=== Study of choice === | |||
* [[Kidney biopsy|Renal biopsy]] is the gold standard diagnostic test for the diagnosis of membranoproilferative glomerulonephritis<ref name="pmid22435371">{{cite journal| author=Sethi S, Fervenza FC| title=Membranoproliferative glomerulonephritis--a new look at an old entity. | journal=N Engl J Med | year= 2012 | volume= 366 | issue= 12 | pages= 1119-31 | pmid=22435371 | doi=10.1056/NEJMra1108178 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22435371 }} </ref>. | |||
** Light microscopy, electron dense microscopy and immunofluorescence are performed on the renal biopsy sample. | |||
=== Diagnostic results === | |||
====== Light microscopy ====== | |||
* The findings of [[glomerulus]] with increased mesangial cellularity, increase in the [[Mesangial cell|mesangial]] matrix, and thickened peripheral capillary walls are confirmatory for the disease. | |||
====== Electron microscopy ====== | |||
* Immune deposits in the mesangium and subendothelial space. | |||
====== Immunoflourescence ====== | |||
* Presence of immunoglobulins or [[complement]] in the mesangium depending on the cause. | |||
== References == | |||
{{reflist|2}} | |||
Latest revision as of 20:19, 6 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2] Syed Ahsan Hussain, M.D.[3]
Overview
Renal biopsy is considered the gold standard diagnostic test for MPGN.
Diagnostic study of choice
Study of choice
- Renal biopsy is the gold standard diagnostic test for the diagnosis of membranoproilferative glomerulonephritis[1].
- Light microscopy, electron dense microscopy and immunofluorescence are performed on the renal biopsy sample.
Diagnostic results
Light microscopy
- The findings of glomerulus with increased mesangial cellularity, increase in the mesangial matrix, and thickened peripheral capillary walls are confirmatory for the disease.
Electron microscopy
- Immune deposits in the mesangium and subendothelial space.
Immunoflourescence
- Presence of immunoglobulins or complement in the mesangium depending on the cause.
References
- ↑ Sethi S, Fervenza FC (2012). "Membranoproliferative glomerulonephritis--a new look at an old entity". N Engl J Med. 366 (12): 1119–31. doi:10.1056/NEJMra1108178. PMID 22435371.