Creutzfeldt-Jakob disease other diagnostic studies: Difference between revisions
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{{Creutzfeldt-Jakob disease}} | {{Creutzfeldt-Jakob disease}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
[[Biopsy]] of the [[brain]] tissue is the definitive diagnostic test for Creutzfeldt-Jakob disease(CJD), but is not usually performed. [[EEG]] findings are not diagnostic of CJD, but may help in the diagnosis of CJD. Typical EEG findings in Creutzfeldt-Jakob disease include periodic biphasic or triphasic sharp wave complexes (PSWCs). Periodic synchronous discharges (PSDs) occur either before or in synchronicity with [[myoclonus]]. | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Biopsy=== | ===Biopsy=== | ||
*Deposits of [[prion]] protein (scrapie), [[PrpSc|PrP<SUP>Sc</SUP>]], can be found in the [[skeletal muscle]] and/or the [[spleen]] (approximately 30% of cases). | |||
*Diagnosis of [[vCJD]] can be supported by biopsy of the [[tonsils]], which harbor significant amounts of PrpSc. | |||
*[[Biopsy]] of the [[brain]] tissue is the definitive diagnostic test, but is not usually performed. | |||
==Gallery== | |||
<gallery> | |||
Image: Creutzfeldt jakob04.jpeg| Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL> | |||
Image: Creutzfeldt jakob03.jpeg| Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL> | |||
Image: Creutzfeldt jakob02.jpeg| Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL> | |||
Image: Creutzfeldt jakob01.jpeg| Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL> | |||
</gallery> | |||
==References== | ==References== | ||
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{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Transmissible spongiform encephalopathies]] | [[Category:Transmissible spongiform encephalopathies]] | ||
Latest revision as of 16:23, 23 October 2018
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Creutzfeldt-Jakob disease Microchapters |
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Differentiating Creutzfeldt-Jakob disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Creutzfeldt-Jakob disease other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Creutzfeldt-Jakob disease other diagnostic studies |
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Creutzfeldt-Jakob disease other diagnostic studies in the news |
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Risk calculators and risk factors for Creutzfeldt-Jakob disease other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Biopsy of the brain tissue is the definitive diagnostic test for Creutzfeldt-Jakob disease(CJD), but is not usually performed. EEG findings are not diagnostic of CJD, but may help in the diagnosis of CJD. Typical EEG findings in Creutzfeldt-Jakob disease include periodic biphasic or triphasic sharp wave complexes (PSWCs). Periodic synchronous discharges (PSDs) occur either before or in synchronicity with myoclonus.
Other Diagnostic Studies
Biopsy
- Deposits of prion protein (scrapie), PrPSc, can be found in the skeletal muscle and/or the spleen (approximately 30% of cases).
- Diagnosis of vCJD can be supported by biopsy of the tonsils, which harbor significant amounts of PrpSc.
- Biopsy of the brain tissue is the definitive diagnostic test, but is not usually performed.
Gallery
-
![Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. From Public Health Image Library (PHIL). [1]](/images/c/cd/Creutzfeldt_jakob04.jpeg)
Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. From Public Health Image Library (PHIL). [1]
-
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [1]](/images/9/90/Creutzfeldt_jakob03.jpeg)
Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [1]
-
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [1]](/images/4/44/Creutzfeldt_jakob02.jpeg)
Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [1]
-
![Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. From Public Health Image Library (PHIL). [1]](/images/c/cc/Creutzfeldt_jakob01.jpeg)
Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. From Public Health Image Library (PHIL). [1]
![Micrograph of brain tissue reveals the cytoarchitectural histopathologic changes found in bovine spongiform encephalopathy. From Public Health Image Library (PHIL). [1]](/index.php/File:Creutzfeldt_jakob04.jpeg)
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [1]](/index.php/File:Creutzfeldt_jakob03.jpeg)
![Photomicrograph of brain tissue stained with H&E reveals the presence of prominent spongiotic changes in the cortex, and loss of neurons in a case of variant Creutzfeldt-Jakob disease (100x mag). From Public Health Image Library (PHIL). [1]](/index.php/File:Creutzfeldt_jakob02.jpeg)
![Neural tissue specimen harvested from a scrapie-affected mouse, revealed the presence of prion protein stained in red. From Public Health Image Library (PHIL). [1]](/index.php/File:Creutzfeldt_jakob01.jpeg)