Paroxysmal nocturnal hemoglobinuria history and symptoms: Difference between revisions
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{{Paroxysmal nocturnal hemoglobinuria}} | {{Paroxysmal nocturnal hemoglobinuria}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{AEL}} | ||
==Overview== | ==Overview== | ||
Common symptoms of paroxysmal nocturnal hemoglobinuria include fatigue, [[dyspnea]], [[headaches]], [[abdominal pain]], [[dysphagia]] and [[chest pain]]. Less common symptoms may include necrotic skin lesions. | |||
==History and Symptoms== | ==History and Symptoms== | ||
===History=== | ===History=== | ||
Patients with | Patients with PNH may have a positive history of: | ||
* | * Feeling tired/ weak | ||
* | * Shortness of breath | ||
* | * Dark colored urine | ||
* | * Jaundice | ||
* | * Blood clots | ||
* | * Difficulty swallowing | ||
* | * Chest pain | ||
* | * Abdominal pain | ||
* | * Headaches | ||
* | * Confusion | ||
* | * Dysphagia | ||
* | * [[Erectile dysfunction]] | ||
* | * Low blood cell counts | ||
* | * Iron deficiency | ||
===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of | Common symptoms of PNH include:<ref name="pmid16051736">{{cite journal| author=Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R et al.| title=Diagnosis and management of paroxysmal nocturnal hemoglobinuria. | journal=Blood | year= 2005 | volume= 106 | issue= 12 | pages= 3699-709 | pmid=16051736 | doi=10.1182/blood-2005-04-1717 | pmc=1895106 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16051736 }}</ref> | ||
* Due to hemolysis | * Due to hemolysis | ||
*# | *# Fatigue | ||
*# | *# Dyspnea | ||
*# | *# Jaundice | ||
* Due to thrombosis | * Due to thrombosis: | ||
*# | *# Headaches | ||
*# | *# Confusion | ||
*# | *# Abdominal pain | ||
*# | *# Chest pain | ||
* Due to nitric oxide depletion | * Due to [[nitric oxide]] depletion: | ||
*# | *# [[Dysphagia]] | ||
*# | *# [[Chest pain]] | ||
*# | *# [[Abdominal pain]] | ||
*# | *# Erectile dysfunction | ||
===Less Common Symptoms=== | ===Less Common Symptoms=== | ||
Less common symptoms of | Less common symptoms of PNH include: | ||
* | * [[Necrotic]] [[skin]] lesions | ||
==References== | ==References== | ||
Latest revision as of 21:30, 1 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Common symptoms of paroxysmal nocturnal hemoglobinuria include fatigue, dyspnea, headaches, abdominal pain, dysphagia and chest pain. Less common symptoms may include necrotic skin lesions.
History and Symptoms
History
Patients with PNH may have a positive history of:
- Feeling tired/ weak
- Shortness of breath
- Dark colored urine
- Jaundice
- Blood clots
- Difficulty swallowing
- Chest pain
- Abdominal pain
- Headaches
- Confusion
- Dysphagia
- Erectile dysfunction
- Low blood cell counts
- Iron deficiency
Common Symptoms
Common symptoms of PNH include:[1]
- Due to hemolysis
- Fatigue
- Dyspnea
- Jaundice
- Due to thrombosis:
- Headaches
- Confusion
- Abdominal pain
- Chest pain
- Due to nitric oxide depletion:
- Dysphagia
- Chest pain
- Abdominal pain
- Erectile dysfunction
Less Common Symptoms
Less common symptoms of PNH include:
References
- ↑ Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.