Endometrial cancer medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV. | The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of [[chemotherapy]] and [[radiation therapy]] is indicated in stages IIIB- IV. | ||
==Medical Therapy== | ==Medical Therapy== | ||
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* Chemotherapy without prior surgery is usually reserved for patients with stage IV endometrial cancer or patients that are not surgical candidates. | * Chemotherapy without prior surgery is usually reserved for patients with stage IV endometrial cancer or patients that are not surgical candidates. | ||
** Typically a platinum based combination regimen or triple druge therapy is used:<ref name="pmid17617530">{{cite journal| author=Fleming GF| title=Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant. | journal=J Clin Oncol | year= 2007 | volume= 25 | issue= 20 | pages= 2983-90 | pmid=17617530 | doi=10.1200/JCO.2007.10.8431 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17617530 }} </ref> | ** Typically a platinum based combination regimen or triple druge therapy is used:<ref name="pmid17617530">{{cite journal| author=Fleming GF| title=Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant. | journal=J Clin Oncol | year= 2007 | volume= 25 | issue= 20 | pages= 2983-90 | pmid=17617530 | doi=10.1200/JCO.2007.10.8431 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17617530 }} </ref> | ||
*** Carboplatin + paclitaxel | *** [[Carboplatin]] + [[paclitaxel]] | ||
*** Cisplatin + doxorubicin + paclitaxel | *** [[Cisplatin]] + [[doxorubicin]] + [[paclitaxel]] | ||
** Endocrine therapy is also used with favorable results in patients with:<ref name="pmid17442022">{{cite journal| author=Decruze SB, Green JA| title=Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. | journal=Int J Gynecol Cancer | year= 2007 | volume= 17 | issue= 5 | pages= 964-78 | pmid=17442022 | doi=10.1111/j.1525-1438.2007.00897.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17442022 }} </ref> | ** Endocrine therapy is also used with favorable results in patients with:<ref name="pmid17442022">{{cite journal| author=Decruze SB, Green JA| title=Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. | journal=Int J Gynecol Cancer | year= 2007 | volume= 17 | issue= 5 | pages= 964-78 | pmid=17442022 | doi=10.1111/j.1525-1438.2007.00897.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17442022 }} </ref> | ||
*** Endometroid endmetrial cancer | *** [[Endometroid]] endmetrial cancer | ||
*** Express estrogen and progesterone receptors | *** Express [[estrogen]] and [[progesterone]] receptors | ||
*** Asymptomatic disease | *** Asymptomatic disease | ||
Latest revision as of 16:38, 29 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]
Overview
The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
Medical Therapy
- The optimal therapy for endometrial cancer depends on the stage at diagnosis. A combination of chemotherapy and radiation therapy is indicated in stages IIIB- IV.
- Chemotherapy is not the first-line treatment option for patients with stage I-III endometrial cancer. Surgery is the mainstay of treatment.
- Chemotherapy without prior surgery is usually reserved for patients with stage IV endometrial cancer or patients that are not surgical candidates.
- Typically a platinum based combination regimen or triple druge therapy is used:[1]
- Endocrine therapy is also used with favorable results in patients with:[2]
- Endometroid endmetrial cancer
- Express estrogen and progesterone receptors
- Asymptomatic disease
References
- ↑ Fleming GF (2007). "Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant". J Clin Oncol. 25 (20): 2983–90. doi:10.1200/JCO.2007.10.8431. PMID 17617530.
- ↑ Decruze SB, Green JA (2007). "Hormone therapy in advanced and recurrent endometrial cancer: a systematic review". Int J Gynecol Cancer. 17 (5): 964–78. doi:10.1111/j.1525-1438.2007.00897.x. PMID 17442022.