Sideroblastic anemia surgery: Difference between revisions
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{{Sideroblastic anemia}} | {{Sideroblastic anemia}} | ||
{{CMG}} {{AE}} {{N.F}} | {{CMG}} {{AE}} {{N.F}} | ||
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== Indications == | == Indications == | ||
* Surgery is not the first-line treatment option for patients with sideroblastic anemia.<ref name="pmid27026139">{{cite journal |vauthors=Rouault TA |title=Mitochondrial iron overload: causes and consequences |journal=Curr. Opin. Genet. Dev. |volume=38 |issue= |pages=31–37 |date=June 2016 |pmid=27026139 |pmc=5035716 |doi=10.1016/j.gde.2016.02.004 |url=}}</ref> | * Surgery is not the first-line treatment option for patients with sideroblastic anemia.<ref name="pmid27026139">{{cite journal |vauthors=Rouault TA |title=Mitochondrial iron overload: causes and consequences |journal=Curr. Opin. Genet. Dev. |volume=38 |issue= |pages=31–37 |date=June 2016 |pmid=27026139 |pmc=5035716 |doi=10.1016/j.gde.2016.02.004 |url=}}</ref> | ||
* The [[Indications and usage|indications]] for | * The [[Indications and usage|indications]] for surgery are: | ||
** | ** Young patients with congenital sideroblastic anemia, not responsive to [[pyridoxine]] | ||
** [[Blood transfusion|Transfusion]] dependent patients | ** [[Blood transfusion|Transfusion]] dependent patients | ||
** [[Liver cirrhosis]] | ** [[Liver cirrhosis]] | ||
** [[Iron overload disorder|Iron overload]] refractory to | ** [[Iron overload disorder|Iron overload]] refractory to [[iron]] chelation therapy | ||
** [[Iron overload disorder|Iron overload]] refractory to [[phlebotomy]] | |||
** | |||
== Contraindications == | == Contraindications == | ||
* Patients with organ damage from | * Patients with organ damage from secondary hemochromatosis | ||
* Poor surgical candidacy | |||
==References== | ==References== | ||
Latest revision as of 20:03, 19 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.
Overview
In severe cases, bone marrow transplant is the only option with limited information about the success rate.
Surgery
Indications
- Surgery is not the first-line treatment option for patients with sideroblastic anemia.[1]
- The indications for surgery are:
- Young patients with congenital sideroblastic anemia, not responsive to pyridoxine
- Transfusion dependent patients
- Liver cirrhosis
- Iron overload refractory to iron chelation therapy
- Iron overload refractory to phlebotomy
Contraindications
- Patients with organ damage from secondary hemochromatosis
- Poor surgical candidacy
References
- ↑ Rouault TA (June 2016). "Mitochondrial iron overload: causes and consequences". Curr. Opin. Genet. Dev. 38: 31–37. doi:10.1016/j.gde.2016.02.004. PMC 5035716. PMID 27026139.