Guillain-Barré syndrome diagnostic study of choice: Difference between revisions
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== Overview == | == Overview == | ||
There is no single diagnostic study of choice for Guillain Barre syndrome, though GBS may be diagnosed based on NINDS criteria established by [[National Institute of Neurological Disorders and Stroke]]: Progressive ascending weakness or [[paralysis]] usually starting from legs, involving are 4 [[limbs]], the [[trunk]], [[bulbar]] and facial muscles, and external ocular muscles and [[Areflexia]] or decreased reflexes in affected limbs. | |||
== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
=== Diagnostic Criteria === | === Diagnostic Criteria === | ||
* There is no single diagnostic study of choice for Guillain Barre syndrome, though GBS may be diagnosed based on NINDS criteria established by National Institute of Neurological Disorders and Stroke:<ref name="pmid2194422">{{cite journal |vauthors=Asbury AK, Cornblath DR |title=Assessment of current diagnostic criteria for Guillain-Barré syndrome |journal=Ann. Neurol. |volume=27 Suppl |issue= |pages=S21–4 |date=1990 |pmid=2194422 |doi= |url=}}</ref><ref name="pmid677829">{{cite journal |vauthors= |title=Criteria for diagnosis of Guillain-Barré syndrome |journal=Ann. Neurol. |volume=3 |issue=6 |pages=565–6 |date=June 1978 |pmid=677829 |doi=10.1002/ana.410030628 |url=}}</ref> | * There is no single diagnostic study of choice for Guillain Barre syndrome, though GBS may be diagnosed based on NINDS criteria established by [[National Institute of Neurological Disorders and Stroke]]:<ref name="pmid2194422">{{cite journal |vauthors=Asbury AK, Cornblath DR |title=Assessment of current diagnostic criteria for Guillain-Barré syndrome |journal=Ann. Neurol. |volume=27 Suppl |issue= |pages=S21–4 |date=1990 |pmid=2194422 |doi= |url=}}</ref><ref name="pmid677829">{{cite journal |vauthors= |title=Criteria for diagnosis of Guillain-Barré syndrome |journal=Ann. Neurol. |volume=3 |issue=6 |pages=565–6 |date=June 1978 |pmid=677829 |doi=10.1002/ana.410030628 |url=}}</ref> | ||
** Progressive ascending weakness or paralysis usually starting from legs, involving are 4 limbs, the trunk, bulbar and facial muscles, and external ocular muscles. | ** Progressive ascending weakness or [[paralysis]] usually starting from legs, involving are 4 [[limbs]], the [[trunk]], [[bulbar]] and facial muscles, and external ocular muscles. | ||
** Areflexia or decreased reflexes in affected limbs. | ** [[Areflexia]] or decreased reflexes in affected limbs. | ||
* these findings can make the GBS diagnosis even more possible: | * these findings can make the GBS diagnosis even more possible: | ||
** Progression of symptoms over days to four weeks | ** Progression of [[symptoms]] over days to four weeks | ||
** Relative symmetry | ** Relative symmetry | ||
** Sensory abnormalities | ** Sensory abnormalities | ||
** Cranial nerve involvement, especially bilateral facial nerve weakness | ** Cranial nerve involvement, especially bilateral facial nerve weakness | ||
** Recovery starting two to four weeks after progression stops | ** Recovery starting two to four weeks after progression stops | ||
** Autonomic disturbance | ** [[Autonomic dysfunction|Autonomic disturbance]] | ||
** Pain | ** [[Pain]] | ||
** absence of fever in the acute phase | ** absence of fever in the acute phase | ||
** Elevated CSF protein level | ** Elevated [[CSF]] protein level | ||
** CSF cell count ≤50/mm<sup>3</sup> | ** CSF cell count ≤50/mm<sup>3</sup> | ||
** Electrodiagnostic abnormalities consistent with GBS | ** Electrodiagnostic abnormalities consistent with GBS | ||
Latest revision as of 16:53, 27 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.
Overview
There is no single diagnostic study of choice for Guillain Barre syndrome, though GBS may be diagnosed based on NINDS criteria established by National Institute of Neurological Disorders and Stroke: Progressive ascending weakness or paralysis usually starting from legs, involving are 4 limbs, the trunk, bulbar and facial muscles, and external ocular muscles and Areflexia or decreased reflexes in affected limbs.
Diagnostic Study of Choice
Diagnostic Criteria
- There is no single diagnostic study of choice for Guillain Barre syndrome, though GBS may be diagnosed based on NINDS criteria established by National Institute of Neurological Disorders and Stroke:[1][2]
- these findings can make the GBS diagnosis even more possible:
- Progression of symptoms over days to four weeks
- Relative symmetry
- Sensory abnormalities
- Cranial nerve involvement, especially bilateral facial nerve weakness
- Recovery starting two to four weeks after progression stops
- Autonomic disturbance
- Pain
- absence of fever in the acute phase
- Elevated CSF protein level
- CSF cell count ≤50/mm3
- Electrodiagnostic abnormalities consistent with GBS